细胞周期调节因子在分化中的作用-猫眼课题宝

细胞周期调节因子在分化中的作用

批准号：

8619666

负责人：

Patrizia Casaccia

金额：

$36.71万

依托单位：

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

依托单位国家：

美国

项目类别：

财政年份：

2007

资助国家：

美国

项目状态：

已结题

起止时间：

2007-06-15 至 2016-02-29

来源：

https://reporter.nih.gov/project-details/8619666

关键词：

Affect Binding Cancer Biology Cell Cycle Cell Cycle Proteins Cell Differentiation process Cells ChIP-seq Chromatin Chromatin Structure Co-Immunoprecipitations Collaborations Complex Data Deacetylation Development Discipline Dominant-Negative Mutation Down-Regulation E2F1 gene Energy Metabolism Enzymes Family Family member Funding Gene Cluster Gene Expression Gene Expression Profile Gene Targeting Genes Genetic Glioblastoma Grant HDAC1 gene Histone Acetylation Histones In Vitro Internal Ribosome Entry Site Kinetics Knowledge Link Malignant Neoplasms Mediating Metabolic Modeling Molecular Mus Nodal Oligodendroglia Oncogenes Pathology Physical condensation Physiological Proliferating Proteins Regulator Genes Role Shapes Sorting - Cell Movement Specificity Stem cells Testing Time Transcriptional Regulation Up-Regulation Validation c-Myc Staining Method cancer cell cdc Genes chromatin immunoprecipitation developmental neurobiology gene repression histone acetyltransferase in vivo interest member metaplastic cell transformation mouse model myelination nervous system disorder neuro-oncology neurodevelopment novel novel therapeutics nuclear reprogramming oligodendrocyte lineage prevent progenitor programs repaired

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中文摘要

翻译

描述(由申请人提供)：我们的实验室已经确定了Myc和E2F家族的细胞周期调节器成员与染色质变化和少突胶质细胞前体细胞分化的转录调控之间的有趣关系。我们现在建议使用原代培养和遗传小鼠模型来测试一种新的少突胶质细胞分化的机制模型。拟议的实验计划的结果可能不仅会促进我们在神经发育和修复方面的知识，而且还会促进癌症和核重新编程方面的知识，并对开发新的治疗策略具有广泛的意义。

英文摘要

DESCRIPTION (provided by applicant): Our lab has identified an interesting relation between members of the Myc and E2f family of cell cycle regulators and chromatin changes and transcriptional regulation of differentiation of oligodendrocyte progenitors. We now propose to use primary cultures and genetic mouse models to test a new mechanistic model of oligodendrocyte differentiation. The results from the proposed experimental plan are likely to advance our knowledge not only in neural development and repair, but also in cancer and nuclear reprogramming and have wide implications for the development of novel therapeutic strategies.

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