Aerobic Exercise and Cognitive Training in Older Adults

老年人的有氧运动和认知训练

• 批准号: 8499095
• 负责人: Joe Robert Nocera
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8499095
• 关键词: Address; Adherence; Advanced Development; Aerobic Exercise; Age; Age-associated memory impairment; Area; Bachelor' s Degree; Brain; California; Clinical; Clinical Trials; Cognition; Cognitive; Cognitive aging; Development; Doctor of Philosophy; Education; Elderly; Fellowship; Florida; Funding; Goals; Graduate Degree; Grant; Image; Impaired cognition; Intervention; Investigation; K-Series Research Career Programs; Kinesiology; Language; Lead; Life; Los Angeles; Measurement; Mentors; Neuroanatomy; Neurology; Nevada; Patients; Physical Function; Postdoctoral Fellow; Principal Investigator; Quality of life; Randomized; Rehabilitation therapy; Research; Risk; Scientist; System; Training; Training Programs; Translating; Translational Research; United States National Institutes of Health; Universities; Veterans; Work; arm; base; career development; cognitive function; cognitive neuroscience; cognitive training; design; disability; executive function; fitness; group intervention; improved; improved functioning; programs; skills; therapy design

DESCRIPTION This proposal, "Aerobic Exercise and Cognitive Training in Older Adults", is resubmission for a Career Development Award- Level 2 with Dr. Joe R. Nocera as the Principal Investigator and a mentoring team of Drs. Bruce Crosson, Ron Shorr, Marco Pahor and Michael Marsiske. Dr. Nocera received his undergraduate degree (B.A., 2001) from the University of California, Los Angeles. He completed his graduate degrees in Kinesiology from the University of Nevada, Las Vegas (M.S., 2004) and the University of Georgia (Ph.D., 2007). Following completion of his terminal degree, Dr. Nocera earned a post- doctoral fellowship under a National Institute of Health T32 training grant within the Department of Neurology at the University of Florida. Dr. Nocera then received a CDA-1 aimed at studying the effects aerobic exercise on executive language function in older adults. It was hypothesized, and demonstrated in the preliminary CDA-1 work, that the robust documented benefits of aerobic exercise on cognition could carry over to more specific executive language functions. Concurrently, the CDA-1 was designed to increase Dr. Nocera's understands of cognitive neuroscience thus bridges the gap between cognitive functions and Dr. Nocera's previous education emphasis of physical function in older adults. The general purpose of the career development in this CDA-2 application is to further and more substantially develop Dr. Nocera's understanding of cognitive neuroscience for the purpose of designing interventions aimed at improving function and quality of life in older veterans. Specific training components in the proposal include; skills in cognitive neuroscience with specific training in cognitive aging, measurement, neuroanatomy, and basic imaging approaches. Additionally, the proposal is designed to develop Dr. Nocera's skills in clinical/translational research necessary for high-quality clinical trials research. The purpose of the CDA-2 study will build on the CDA-1, which demonstrating an improvement in cognitive function via aerobic exercise, by adding a cognitive training component that will be done immediately following the aerobic exercise. It is hypothesized that the aerobic exercise will potentiate and increase the generalizability of the cognitive training. Importantly, this study wil focus on older veterans at-risk for mobility disability. This area is of particular importance for he VA system, considering a large percentage of veterans are entering old age and therefore likely to suffer from age-related cognitive decline and mobility disability. To address our research question 60 older veterans (age 65-89) will be randomized to one of two 12-week intervention groups: 1) Cognitive Training alone (CT) or 2) Aerobic Exercise + Cognitive Training (AE+CT). The aerobic exercise arm of the study will follow the same format shown to improve a broad range of executive functions in older adults in previous research as well as our CDA-1 pilot work. The cognitive training arm will consists of a popular commercially-available brain fitness program that has demonstrated specific cognitive improvements and high adherence. Ultimately, this investigation will substantially advance the development of treatments for cognitive impairment because these goals explore an intervention that may potentially have pervasive effects on patient quality of life from a cognitive as well as a physical standpoint. Concurrently, this proposal will provide Dr. Nocera with the skill necessary to grow into a successful, independent VA Research.

描述 这项名为“老年人的有氧运动和认知训练”的提案是重新提交职业发展奖 - 二级，由 Joe R. Nocera 博士担任首席研究员，并由 Drs. Joe R. Nocera 博士组成的指导团队。布鲁斯·克罗森、罗恩·肖尔、马可·帕霍尔和迈克尔·马西斯克。 Nocera 博士在加州大学洛杉矶分校获得本科学位（文学学士学位，2001 年）。他在内华达大学拉斯维加斯分校（硕士，2004 年）和佐治亚大学（博士，2007 年）获得了运动机能学研究生学位。完成最终学位后，Nocera 博士获得了佛罗里达大学神经病学系国家卫生研究院 T32 培训资助的博士后奖学金。随后，Nocera 博士收到了 CDA-1，旨在研究有氧运动对老年人执行语言功能的影响。据推测，并在 CDA-1 的初步工作中证明，有氧运动对认知的明显益处可以延续到更具体的执行语言功能。同时，CDA-1 旨在增加诺塞拉博士对认知神经科学的理解，从而弥合认知功能与诺塞拉博士之前对老年人身体功能的教育重点之间的差距。此 CDA-2 申请中职业发展的总体目的是进一步更实质性地发展 Nocera 博士对认知神经科学的理解，以便设计旨在改善老年退伍军人的功能和生活质量的干预措施。提案中的具体培训内容包括：认知神经科学技能，接受认知衰老、测量、神经解剖学和基本成像方法方面的专门培训。此外，该提案旨在培养诺塞拉博士进行高质量临床试验研究所需的临床/转化研究技能。目的 CDA-2研究将以CDA-1为基础，通过添加在有氧运动后立即进行的认知训练成分，证明有氧运动可以改善认知功能。据推测，有氧运动将增强并提高认知训练的普遍性。重要的是，这项研究将重点关注有行动障碍风险的老年退伍军人。考虑到很大一部分退伍军人即将进入老年，因此可能会遭受与年龄相关的认知能力下降和行动障碍，这一领域对于退伍军人事务部系统尤其重要。为了解决我们的研究问题，60 名老年退伍军人（65-89 岁）将被随机分配到两个为期 12 周的干预组之一：1）单独认知训练（CT）或 2）有氧运动 + 认知训练（AE+CT）。该研究的有氧运动部分将遵循先前研究以及我们的 CDA-1 试点工作中显示的可改善老年人广泛执行功能的相同格式。认知训练部门将包括一种流行的商业大脑健身计划，该计划已证明具有特定的认知改善和高依从性。最终，这项研究将极大地推进认知障碍治疗的发展，因为这些目标探索了一种可能从认知和身体角度对患者生活质量产生普遍影响的干预措施。同时，该提案将为 Nocera 博士提供成长为成功、独立的 VA 研究所需的技能。