Effects of Aging on Cortical Excitability During Motor Learning

衰老对运动学习过程中皮质兴奋性的影响

• 批准号: 10734034
• 负责人: Joe Robert Nocera
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-10-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10734034
• 关键词: Accounting; Adult; Aerobic; Aerobic Exercise; Affect; Age; Aging; Area; Award; Behavior Therapy; Behavioral; Brain; Cephalic; Characteristics; Data; Effectiveness; Elderly; Enrollment; Equilibrium; Exercise; Exhibits; GABA Receptor; Hand; Intake; Intervention; Joints; Knowledge; Light; Link; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measurement; Measures; Mediating; Modality; Motor; Motor Cortex; Neural Inhibition; Neurologic; Neuronal Plasticity; Neurotransmitter Receptor; Neurotransmitters; Outcome; Participant; Patients; Performance; Physical activity; Quality of life; Randomized; Rehabilitation therapy; Research; Scanning; Stretching; System; Techniques; Training; Transcranial magnetic stimulation; Translating; Upper Extremity; Veterans; Work; age effect; aging brain; cohort; critical period; dexterity; efficacious intervention; exercise intervention; exercise program; exercise regimen; functional loss; gamma-Aminobutyric Acid; hand dysfunction; improved; indexing; intervention program; motor behavior; motor control; motor impairment; motor learning; motor rehabilitation; multimodality; neurophysiology; noninvasive brain stimulation; receptor; receptor function; receptor sensitivity; remediation; sedentary; senescence; young adult

The current proposal seeks quantify neural inhibition using magnetic resonance spectroscopy (MRS) and transcranial magenetic stimulation (TMS) in older Veterans to identify how each measures contributes to aging-related changes in motor performance. Currently, over 56% (11.8 million) of Veterans are over age 60. Recent research has shown that aging is associated with decreased cortical inhibition and impaired hand motor function. However, this loss of inhibition is not an inescapable consequence of aging. Our previous work that healthy older adults who engage in regular physical activity show increased cortical inhibition and improved dexterity as compared to their sedentary age cohort. This indicates that aerobic training may reverse aging related changes in cortical inhibition and alteration of tonic levels of cortical excitability can have a powerful impact on motor performance in the aging brain. In the current proposal, we will enroll older adults to assess how different measurements (TMS and MRS) of the dominant inhibitory neurotransmitter in the brain – GABA differ in relation to motor control. During the MRS scan, participants will perform a motor learning task to assess change in GABA level throughout the acquisition session. These data will be compared with measures of cortical inhibition using TMS to quantify neurotransmitter receptor activity with respect to aging-related changes in motor performance. We will also be comparing the effects of an aerobic exercise intervention as compared to a contact matched stretching control. We believe this project is the first inquiry of its kind and will have an important impact in our understanding of aging-related neurophysiological changes in the brain and how we can remediate associated behavioral declines.

目前的提议寻求使用磁共振波谱（MRS）和 在老年退伍军人中进行经颅磁刺激（TMS），以确定每种措施如何有助于 与年龄相关的运动性能变化。目前，超过56%（1180万）的退伍军人年龄超过60岁。 最近的研究表明，衰老与大脑皮层抑制功能下降和手部受损有关 运动功能然而，这种抑制的丧失并不是衰老的必然结果。我们以前的工作 健康的老年人经常参加体育活动，会表现出更强的皮质抑制， 与久坐的同龄人相比，他们的灵活性有所提高。这表明有氧训练可能会逆转 与年龄相关的皮层抑制变化和皮层兴奋性紧张水平的改变， 对老化大脑的运动表现有着强大的影响。在目前的提案中，我们将招收老年人， 评估大脑中主要抑制性神经递质的不同测量（TMS和MRS）- GABA与运动控制有关。在MRS扫描期间，参与者将执行运动学习任务， 评估整个采集过程中GABA水平的变化。这些数据将与测量结果进行比较。 皮质抑制使用TMS量化神经递质受体活性相对于衰老相关 运动性能的变化。我们还将比较有氧运动干预的效果， 与接触匹配拉伸对照相比。我们相信这个项目是第一次调查， 对我们理解大脑中与衰老相关的神经生理学变化具有重要影响， 我们如何补救相关的行为衰退。

项目成果

A review of combined neuromodulation and physical therapy interventions for enhanced neurorehabilitation.

• DOI: 10.3389/fnhum.2023.1151218
• 发表时间: 2023
• 期刊: Frontiers in human neuroscience
• 影响因子: 2.9

Urinary incontinence-related effects on functional connectivity circuits in persons with Parkinson's disease.

尿失禁相关对帕金森病患者功能连接回路的影响。

• DOI: 10.1002/nau.25258
• 发表时间: 2023
• 期刊: Neurourology and urodynamics
• 影响因子: 2
• 作者: Denmon,Chanse;Wakeman,DanielG;Vernon,Mark;McGregor,Keith;Krishnamurthy,Venkatagiri;Krishnamurthy,Lisa;Stevens,Jennifer;Vaughan,CamilleP
• 通讯作者: Vaughan,CamilleP

Effects of exercise on the sleep microarchitecture in the aging brain: A study on a sedentary sample.

• DOI: 10.3389/fnsys.2022.855107
• 发表时间: 2022
• 期刊: FRONTIERS IN SYSTEMS NEUROSCIENCE
• 影响因子: 3
• 作者: Cassim, Tuan Z.;McGregor, Keith M.;Nocera, Joe R.;Garcia, Violet V.;Sinon, Christopher G.;Kreuzer, Matthias;Garcia, Paul S.
• 通讯作者: Garcia, Paul S.

Integrative learning for population of dynamic networks with covariates.

• DOI: 10.1016/j.neuroimage.2021.118181
• 发表时间: 2021-08-01
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Kundu S;Ming J;Nocera J;McGregor KM
• 通讯作者: McGregor KM

The effect of time since stroke, gender, age, and lesion size on thalamus volume in chronic stroke: a pilot study.

• DOI: 10.1038/s41598-020-76382-x
• 发表时间: 2020-11-24
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Krishnamurthy LC;Champion GN;McGregor KM;Krishnamurthy V;Turabi A;Roberts SR;Nocera JR;Borich MR;Rodriguez AD;Belagaje SR;Harrington RM;Harris-Love ML;Harnish SM;Drucker JH;Benjamin M;Meadows ML;Seeds L;Zlatar ZZ;Sudhyadhom A;Butler AJ;Garcia A;Patten C;Trinastic J;Kautz SA;Gregory C;Crosson BA
• 通讯作者: Crosson BA