Graded Intensity Aerobic Exercise to Improve Cerebrovascular Function and Performance in Aged Veterans

分级强度有氧运动可改善老年退伍军人的脑血管功能和表现

基本信息

  • 批准号:
    10599855
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-04-01 至 2024-03-31
  • 项目状态:
    已结题

项目摘要

To address the growing healthcare challenges of an aging Veteran population it is critical to understand effective rehabilitation techniques that mitigate age-related co-morbidity and improve quality of life. To date, exercise is one of a few proven interventions that attenuates age-related declines in brain health and function. A consistent but unexplained finding in many of these studies is a change in the cortical activation pattern during task, assessed using blood-oxygen-level dependent (BOLD) signal with fMRI that corresponds with improved task performance. Two key metrics of cerebrovascular health and functioning that are underexplored but may influence the documented changes in the BOLD response that is observed with post-aerobic activity are: 1) changes in resting or basal cerebral blood flow (perfusion) to key brain regions; and 2) changes in the ability of cerebrovasculature to dilate in the face of increased demand, termed cerebrovascular reactivity (CVR). Our goal is to quantify the impact of aerobic exercise on cerebrovascular function and how both perfusion and CVR contributes to the BOLD signal during task-based fMRI. Consistent with our previous aging and exercise studies participants will complete one of two conditions; 1) an aerobic, interval-training intervention (Spin; n= 44), or 2) a non-aerobic, stretching control condition (Control; n=44). Cardiovascular fitness, arterial spin labeling for basal cerebral perfusion, CVR, task-based fMRI (cognitive-executive and motor), and behavioral outcomes will be assessed before and after the interventions. The specific aims will determine the effect of a 12-week aerobic exercise intervention on changes in cerebral perfusion and CVR in older Veterans. We hypothesize that compared to the Control group, the aerobically-trained group will have increased basal perfusion and CVR in areas that demonstrate age-related decline and that have been demonstrated to be malleable to aerobic exercise (inferior frontal and motor cortices). Research over the last few decades have driven the continual promotion of exercise as one of the most impactful interventions of central nervous system health and function. At the forefront of much of this research is the use of task-based fMRI BOLD to quantify beneficial changes in cortical function following aerobic exercise. While transformative, the true impact of this research is limited in scope until we can define the influence of cerebrovascular function on the well-documented beneficial change in BOLD response. We do know that older adults who are physically active have improved vascular health but we do not know the full impact of an exercise intervention on cerebrovascular health. If our hypotheses of improved perfusion and CVR is supported it would inform current intervention strategies and would add important additional information about the potential of exercise to improve brain health in aging. This would have implications for aging Veterans at risk for neurodegenerative disease brought on by cerebrovascular dysfunction.
为了解决老龄化的退伍军人人口日益增长的医疗保健挑战,了解这一点至关重要

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Joe Robert Nocera其他文献

Joe Robert Nocera的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Joe Robert Nocera', 18)}}的其他基金

Graded Intensity Aerobic Exercise to Improve Cerebrovascular Function and Performance in Aged Veterans
分级强度有氧运动可改善老年退伍军人的脑血管功能和表现
  • 批准号:
    10356072
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Graded Intensity Aerobic Exercise to Improve Cerebrovascular Function and Performance in Aged Veterans
分级强度有氧运动可改善老年退伍军人的脑血管功能和表现
  • 批准号:
    10916172
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Graded Intensity Aerobic Exercise to Improve Cerebrovascular Function and Performance in Aged Veterans
分级强度有氧运动可改善老年退伍军人的脑血管功能和表现
  • 批准号:
    9900570
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Effects of Aging on Cortical Excitability During Motor Learning
衰老对运动学习过程中皮质兴奋性的影响
  • 批准号:
    10734034
  • 财政年份:
    2018
  • 资助金额:
    --
  • 项目类别:
Effects of Aging on Cortical Excitability During Motor Learning
衰老对运动学习过程中皮质兴奋性的影响
  • 批准号:
    10385683
  • 财政年份:
    2018
  • 资助金额:
    --
  • 项目类别:
Center for Visual and Neurocognitive Rehabilitation
视觉和神经认知康复中心
  • 批准号:
    10347498
  • 财政年份:
    2017
  • 资助金额:
    --
  • 项目类别:
Aerobic Exercise and Cognitive Training in Older Adults
老年人的有氧运动和认知训练
  • 批准号:
    8279019
  • 财政年份:
    2012
  • 资助金额:
    --
  • 项目类别:
Aerobic Exercise and Cognitive Training in Older Adults
老年人的有氧运动和认知训练
  • 批准号:
    9077092
  • 财政年份:
    2012
  • 资助金额:
    --
  • 项目类别:
Aerobic Exercise and Cognitive Training in Older Adults
老年人的有氧运动和认知训练
  • 批准号:
    8499095
  • 财政年份:
    2012
  • 资助金额:
    --
  • 项目类别:
Aerobic Exercise and Cognitive Training in Older Adults
老年人的有氧运动和认知训练
  • 批准号:
    9455470
  • 财政年份:
    2012
  • 资助金额:
    --
  • 项目类别:

相似海外基金

Concurrent Aerobic Exercise and Cognitive Training to Prevent Alzheimer's in at-risk Older Adults
同时进行有氧运动和认知训练可预防高危老年人的阿尔茨海默病
  • 批准号:
    10696409
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
Effect of aerobic exercise-induced sleep changes on arterial stiffness associated with postprandial hyperglycemia.
有氧运动引起的睡眠变化对与餐后高血糖相关的动脉僵硬度的影响。
  • 批准号:
    23K10645
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Supporting Aging through Green Exercise (SAGE): Comparing the cognitive effects of outdoor versus indoor aerobic exercise in older adults with mild cognitive impairment: A proof-of-concept randomized controlled trial
通过绿色运动支持老龄化 (SAGE):比较户外与室内有氧运动对患有轻度认知障碍的老年人的认知效果:概念验证随机对照试验
  • 批准号:
    495185
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
The Effects of Aerobic Exercise on Cardiovascular Health in Postmenopausal Females: A Systematic Review and Meta-Analysis
有氧运动对绝经后女性心血管健康的影响:系统评价和荟萃分析
  • 批准号:
    480729
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
Aerobic Exercise Recommendations to Optimize Best Practices In Care after Stroke: AEROBICS 2024 Update
用于优化中风后护理最佳实践的有氧运动建议:AEROBICS 2024 更新
  • 批准号:
    480888
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Miscellaneous Programs
The influence of aerobic exercise on consolidation of fear extinction learning in PTSD
有氧运动对PTSD患者恐惧消退学习巩固的影响
  • 批准号:
    10840496
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
Improving Cognition Through Telehealth Aerobic Exercise and Cognitive Training After a First Schizophrenia Episode
在首次精神分裂症发作后通过远程医疗有氧运动和认知训练提高认知能力
  • 批准号:
    10647268
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
The influence of aerobic exercise on consolidation of fear extinction learning in PTSD
有氧运动对PTSD患者恐惧消退学习巩固的影响
  • 批准号:
    10630706
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
Examining Time and Nutrient Dependent Effects of Aerobic Exercise on Energy Metabolism in Adults with Overweight and Obesity
检查有氧运动对超重和肥胖成人能量代谢的时间和营养依赖性影响
  • 批准号:
    10886945
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
Enhancing cognitive function in breast cancer survivors through community-based aerobic exercise training
通过社区有氧运动训练增强乳腺癌幸存者的认知功能
  • 批准号:
    10691808
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了