Intraductal carcinoma of the prostate: indicator of aggressive disease.

前列腺导管内癌：侵袭性疾病的指标。

• 批准号: nhmrc : 1077799
• 负责人: A/Pr Declan Murphy
• 金额: $ 58.97万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/intraductal-carcinoma-prostate-aggressive-disease/518535
• 关键词: Intraductal; carcinoma; prostate; indicator; aggressive

This proposal addresses the need to improve personalised treatment decisions for men with high risk familial prostate cancer as they have a very aggressive disease progression with a very poor clinical outcome. We will perform biological and pre-clinical studies to improve the clinical diagnosis, prognosis and treatment options for men with germline mutations in BRCA2 or BRCA1 genes who develop prostate cancer.

这项建议解决了为患有高危家族性前列腺癌的男性改进个性化治疗决策的必要性，因为他们的疾病进展非常激进，临床结果非常差。我们将进行生物学和临床前研究，以改善患有前列腺癌的BRCA2或BRCA1基因胚系突变男性的临床诊断、预后和治疗选择。