Innovative Training to Improve CER PCOR Systematic Review Production and Uptake

描述(由申请人提供)：2010年《平价医疗法案》创造了对合格研究人员进行比较有效性和以患者为中心的结果研究(CER/PCOR)的前所未有的需求。在不久的将来，现有的培训计划无法满足这一需求。虽然CER/PCOR的产生和分析至关重要，但现有的数据量已经超出了我们有效综合这些数据的能力。随着CER走到用于为医疗决策提供信息的证据的前沿，越来越需要确保使用最可靠和最严格的方法来产生这些结果。因此，研究人员需要接受最新方法、标准和技术方面的培训。这项建议将建立在我们在系统审查和荟萃分析方面的开创性培训工作以及用现在属于CER和PCOR的方法教授研究生课程的悠久历史的基础上。我们提出了一个创新的项目，教授CER/PCOR方法，重点是系统审查，以及尖端计算和信息技术，重点是使用说教、异步、同行和经验方法的组合，产生、解释和利用关于最佳医疗实践的证据。我们扩展了传统的CER劳动力定义，以包括消费者和其他非传统群体，如支付者(医疗计划)、专业协会、患者和倡导团体、商业部门(制药)、政府机构、政策制定者、研究资助者、图书馆管理员、记者和立法者。克里斯托弗·施密德博士将领导这项培训工作，具体目标如下：1.在布朗的循证医学中心(CEBM)内创建一个单位，专注于对当前和未来的CER研究人员进行培训和教育，包括非传统团体和消费者。开发可免费获取的创新内容，并针对本RFA要求的教育和培训部分使用创新的交付方法，包括但不限于对观察性研究、登记和临床试验结果的设计、实施、分析和解释进行严格评估，以及使用强大的公开可用的软件工具高效和可靠地进行审查。2.为方法学家、统计学家和其他研究人员建立和维持一个同行学习网络，以交流关于CER/PCOR先进分析技术、研究方法和最佳做法的知识。3.制定和实施定制的体验式学习/研究金方案，让个别研究人员获得使用CER/PCOR方法的直接经验和指导。4.创建R25计划评估单元，向学员和计划提供反馈，用于改进培训的内容和形式。评估教育计划的中长期成果，包括其对CER/PCOR系统审查、原创研究和科学队伍的影响。

DESCRIPTION (provided by applicant): The 2010 Affordable Care Act created an unprecedented need for qualified researchers to carry out comparativeness effectiveness and patient centered outcomes research (CER/PCOR). This need cannot be met by existing training programs in the near future. While the generation and analysis of CER/ PCOR is crucial, the amount of data available already overwhelms our capacity to effectively synthesize it. As CER moves to the forefront of evidence used to inform healthcare decisions, there is an increasing need to ensure that these results are produced using the most reliable and rigorous methods. Thus, researchers need to be trained in the most recent methods, standards, and technologies. This proposal will build on our pioneering training effort in systematic review and meta-analysis and long history of teaching graduate courses in methods that now fall under the umbrella of CER and PCOR. We propose an innovative program to teach CER/PCOR methods focused on systematic review, along with cutting-edge computational and information technology focused on producing, interpreting, and utilizing evidence about best healthcare practices, using a combination of didactic, asynchronous, peer, and experiential methods. We expand upon the traditional CER workforce definition to include consumers and other non-traditional groups, such as payers (health plans), professional societies, patients and advocacy groups, commercial sector (pharmaceuticals), government agencies, policy makers, research funders, librarians, journalists, and legislators. Dr. Christopher Schmid will lead this training effort with the followng specific aims: 1. Create a unit within the Center for Evidence-based Medicine (CEBM) at Brown focused on the training and education of current and future CER researchers, including non-traditional groups and consumers. Develop innovative content that are freely accessible and use innovative delivery approaches for the education and training components requested in this RFA, including and not limited to rigorous assessment of the design, conduct, analysis, and interpretation of results from observational studies, registries, and clinical trials, as well as te use of powerful and publicly available software tools to conduct reviews efficiently and reliably. 2. Create and maintain a peer learning network for methodologists, statisticians, and other researchers to exchange knowledge on advanced CER/PCOR analytic techniques, research methods, and best practices. 3. Develop and implement a customized experiential learning/fellowship program for individual researchers to receive direct experience and mentoring on using CER/PCOR methods. 4. Create an R25 program evaluation unit to provide feedback to learners and to the program, which will be used to refine the contents and format of the training. Assess the intermediate and long term outcomes of the education program, including its effects on CER/PCOR systematic reviews and original research and the scientific workforce.