Innovative Training to Improve CER PCOR Systematic Review Production and Uptake

描述（由申请人提供）：2010年《平价医疗法案》创造了对合格研究人员进行比较有效性和以患者为中心的结局研究（CER/PCOR）的前所未有的需求。在不久的将来，现有的培训方案无法满足这一需要。虽然CER/ PCOR的生成和分析至关重要，但现有数据的数量已经超出了我们有效综合这些数据的能力。随着CER成为用于为医疗保健决策提供信息的最前沿证据，越来越需要确保使用最可靠和最严格的方法生成这些结果。因此，研究人员需要接受最新方法、标准和技术的培训。本提案将以我们在系统审查和荟萃分析方面的开创性培训工作以及采用目前属于CER和变革和组织振兴方案范围内的方法教授研究生课程的悠久历史为基础。我们提出了一个创新的计划，教CER/PCOR方法集中在系统性评价，沿着尖端的计算和信息技术，专注于生产，解释和利用证据的最佳医疗保健实践，使用教学，异步，同行和经验的方法相结合。我们扩展了传统的CER劳动力定义，包括消费者和其他非传统群体，如支付者（健康计划），专业协会，患者和倡导团体，商业部门（制药），政府机构，政策制定者，研究资助者，图书馆员，记者和立法者。克里斯托弗·施密德博士将领导这项培训工作，具体目标如下：1。在布朗大学循证医学中心（CEBM）内创建一个单位，专注于培训和教育当前和未来的CER研究人员，包括非传统群体和消费者。开发可免费访问的创新内容，并使用本RFA中要求的教育和培训部分的创新交付方法，包括但不限于对观察性研究、登记研究和临床试验结果的设计、实施、分析和解释进行严格评估，以及使用强大的公开软件工具有效可靠地进行审查。2.为方法学家、统计学家和其他研究人员创建和维护一个同行学习网络，以交流关于先进的核证的排减量/变革和组织振兴方案分析技术、研究方法和最佳做法的知识。3.制定并实施一项定制的体验式学习/研究金方案，使研究人员个人能够获得关于使用核证减排/变革和组织振兴方法的直接经验和指导。4.创建一个R25计划评估单元，为学习者和计划提供反馈，这些反馈将用于改进培训的内容和形式。评估教育计划的中期和长期成果，包括其对CER/PCOR系统性审查和原创性研究以及科学工作者的影响。

DESCRIPTION (provided by applicant): The 2010 Affordable Care Act created an unprecedented need for qualified researchers to carry out comparativeness effectiveness and patient centered outcomes research (CER/PCOR). This need cannot be met by existing training programs in the near future. While the generation and analysis of CER/ PCOR is crucial, the amount of data available already overwhelms our capacity to effectively synthesize it. As CER moves to the forefront of evidence used to inform healthcare decisions, there is an increasing need to ensure that these results are produced using the most reliable and rigorous methods. Thus, researchers need to be trained in the most recent methods, standards, and technologies. This proposal will build on our pioneering training effort in systematic review and meta-analysis and long history of teaching graduate courses in methods that now fall under the umbrella of CER and PCOR. We propose an innovative program to teach CER/PCOR methods focused on systematic review, along with cutting-edge computational and information technology focused on producing, interpreting, and utilizing evidence about best healthcare practices, using a combination of didactic, asynchronous, peer, and experiential methods. We expand upon the traditional CER workforce definition to include consumers and other non-traditional groups, such as payers (health plans), professional societies, patients and advocacy groups, commercial sector (pharmaceuticals), government agencies, policy makers, research funders, librarians, journalists, and legislators. Dr. Christopher Schmid will lead this training effort with the followng specific aims: 1. Create a unit within the Center for Evidence-based Medicine (CEBM) at Brown focused on the training and education of current and future CER researchers, including non-traditional groups and consumers. Develop innovative content that are freely accessible and use innovative delivery approaches for the education and training components requested in this RFA, including and not limited to rigorous assessment of the design, conduct, analysis, and interpretation of results from observational studies, registries, and clinical trials, as well as te use of powerful and publicly available software tools to conduct reviews efficiently and reliably. 2. Create and maintain a peer learning network for methodologists, statisticians, and other researchers to exchange knowledge on advanced CER/PCOR analytic techniques, research methods, and best practices. 3. Develop and implement a customized experiential learning/fellowship program for individual researchers to receive direct experience and mentoring on using CER/PCOR methods. 4. Create an R25 program evaluation unit to provide feedback to learners and to the program, which will be used to refine the contents and format of the training. Assess the intermediate and long term outcomes of the education program, including its effects on CER/PCOR systematic reviews and original research and the scientific workforce.