Neighborhood Characteristics & Diabetes Incidence in Multiethnic Cohort Study

街区特色

• 批准号: 8535740
• 负责人: KA'IMI ALOHILANI SINCLAIR
• 金额: $ 10.18万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2014-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8535740
• 关键词: Address; Affect; African American; American; Area; Award; Behavior Therapy; Bioinformatics; Biomedical Research; Biometry; Cancer Burden; Cancer Center; Cancer Center Support Grant; Censuses; Characteristics; Cohort Studies; Complex; Computer-Assisted Image Analysis; Country; Data; Data Analyses; Data Set; Databases; Development; Diabetes Mellitus; Diabetes prevention; Diet; Dietary Practices; Dietary Questionnaires; Disadvantaged; Doctor of Philosophy; Economics; Education; Energy Intake; Environment; Environmental Risk Factor; Epidemic; Epidemiology; Ethnic Origin; Ethnic group; Faculty; Food; Food Supplements; Foundations; Funding; Future; Genetic Predisposition to Disease; Genome; Genomics; Geographic Information Systems; Goals; Hawaii; Hawaiian population; Health; Health Food; Health behavior; High Prevalence; Housing; Incidence; Individual; Individual Adjustment; Inequality; Instruction; Intervention; Japanese American; K-Series Research Career Programs; Laboratories; Latino; Life; Los Angeles; Malignant Neoplasms; Maps; Measures; Mentored Research Scientist Development Award; Mentors; Mentorship; Minority; Mission; NCI Center for Cancer Research; NCI-Designated Cancer Center; National Cancer Institute; National Institute of Diabetes and Digestive and Kidney Diseases; Neighborhoods; Non-Insulin-Dependent Diabetes Mellitus; Nutrient; Obesity; Operative Surgical Procedures; Participant; Pattern; Personal Satisfaction; Pharmaceutical Preparations; Physical activity; Physical environment; Population; Population Heterogeneity; Positioning Attribute; Prevalence; Principal Investigator; Public Health; Race; Research; Research Activity; Research Design; Research Personnel; Research Project Grants; Research Training; Resource Sharing; Resources; Risk Factors; Role; SEER Program; Sampling; Services; Social Environment; Socioeconomic Status; Strategic Planning; Technology; Time; Training; Training Programs; Translating; United States National Institutes of Health; Universities; Wages; Work; base; career development; cohort; contextual factors; diabetes control; diabetes risk; diet and cancer; experience; geographic population; health disparity; health equity; low socioeconomic status; medical schools; member; multidisciplinary; multilevel analysis; neighborhood association; novel; nutrition; population based; population health; professor; programs; racial and ethnic; research facility; responsible research conduct; skills; social; socioeconomics; tumor registry

Candidate. The overarching goal of this Mentored Career Development Award (K01) is to provide Dr. Sinclair with the skills and experience to establish an independent program of diabetes-related disparities research. This career development award is grounded in a multilevel population health conceptual framework that merges advanced didactic instruction with individualized one-on-one mentorship. The advanced research training will serve to catalyze Dr. Sinclair's work, which focuses on unexplored contextual factors that contribute to diabetes prevalence and incidence. This award will provide her with time and salary support to develop an educational foundation and research program that broadens her capabilities to carry out multilevel health disparities research. To build this foundation, the training program consists of three core components: 1) formal coursework in epidemiology, biostatistics, Geographic Information Systems (GIS) technology, spatial analysis, and health disparities research, 2) mentored research training in multilevel modeling and GIS, and 3) instruction in the responsible conduct of research. Dr. Sinclair brings together an interdisciplinary mentorship board that offers extensive research experience and support of her career development program. The K01 award will allow her to benefit from a rich, multidisciplinary mentorship and training environment, which includes experts in epidemiology, biostatistics, GIS, diabetes, and health disparities research. Research Project. Dr. Sinclair proposes to empirically examine the spatial patterning and distribution of diabetes risk factors, prevalence and incidence among the Multiethnic Cohort Study participants by combining individual- and area-level data. The Multiethnic Cohort Study includes a diverse population-based sample of more than 100,000 Hawaiian residents, identified in 1993-1996, who have been followed for more than 15 years. In the proposed project, Dr. Sinclair will geocode the residential addresses of study participants at the time of entry into the cohort. Neighborhood socioeconomic status will be defined from the 1990 U.S. Census. Similarly, measures of neighborhood resources for physical activity and access to healthy foods will be defined. Research aims are to: 1) determine the cross-sectional association between neighborhood characteristics and the prevalence of diabetes and individual-level risk factors for diabetes, including obesity, poor diet, and low levels of physical activity, 2) assess the longitudinal association between neighborhood characteristics and the incidence of diabetes after adjustment for individual-level diabetes risk factors, and 3) examine if the association between neighborhood characteristics and diabetes prevalence and incidence differs by race and ethnicity. The use of a multilevel perspective can help to identify factors associated with diabetes-related disparities, and is congruent with the NIH strategic plan to move the country toward health equity. Findings from this study will illuminate the larger social and economic forces that create differences in health between neighborhoods, and identify geographical areas where traditional and novel public health interventions may best be targeted. The K01 award is critical to Dr. Sinclair's future as a diabetes researcher and will provide her with the time, mentorship, research skills, analytical training, and practical research experience to develop into an independently funded investigator in diabetes prevention and control among health disparate populations. Environment. The University of Hawaii at Mnoa is a major education and research facility that serves as the center for research and advanced graduate and professional studies. The UH School of Medicine houses the largest biomedical research facility in Hawaii, and is the most culturally and ethnically diverse medical school in the U.S. Housed within the medical school is the Department of Native Hawaiian Health where Dr. Sinclair is a member of the research faculty. Laurence N. Kolonel, MD, PhD, will serve as Dr. Sinclair's primary mentor. Dr. Kolonel is a Professor at the UH Cancer Research Center and Principal Investigator of the Multiethnic Cohort Study from which Dr. Sinclair will draw her research project. The Cancer Research Center is an NCI-designated cancer center and receives funding from a Cancer Center Support Grant. The Center's mission is to reduce the burden of cancer through research, education, and service with an emphasis on the unique ethnic, cultural, and environmental characteristics of Hawaii and the Pacific. There are currently three cohort studies in the Epidemiology Program, including the Multiethnic Cohort Study. A GIS workgroup, of which Dr. Sinclair is a member, was recently formed to examine contextual factors and cancer incidence. There are several shared resources of the Cancer Center including the Hawaii Tumor registry which is a member of NCI's SEER Program; biostatistics which provides support for study design and data analysis; nutrition support which provides expertise in dietary questionnaire development and maintains extensive food and supplement composition databases; an analytical laboratory capable of analyzing biospecimens and foods for a wide array of constituents; a genomics laboratory which supports studies of genetic susceptibilities and whole-genome expression; and a bioinformatics group which supports the management and analysis of large and complex datasets. While the research activities of the faculty are varied, they are thematically related to the focus on ethnic diversity.

候选人。本次指导职业发展奖（K01）的首要目标是为辛克莱博士提供技能和经验，以建立一个独立的糖尿病相关差异研究项目。这一职业发展奖以多层次人口健康概念框架为基础，该框架将先进的教学指导与个性化的一对一指导相结合。先进的研究培训将有助于催化辛克莱博士的工作，其重点是未被探索的背景因素，有助于糖尿病的患病率和发病率。该奖项将为她提供时间和薪酬支持