Translational Research in GI Cancer

描述(由申请者提供)：一项名为“G1癌症的转化研究”的专门研究计划(SPORT)被提议利用密歇根大学巨大的智力和体力资源，以降低胰腺癌和结直肠癌的发病率和死亡率。该孢子将解决这样一个假设，即确定和开发干预措施，以解决促进细胞癌变或细胞转化表型的分子事件，将通过风险识别、预防性干预、早期发现或改进浸润性癌症的治疗，降低与结直肠癌和胰腺癌相关的发病率和死亡率。这一综合翻译研究计划包括四个主要项目，探索1)鱼油干预作为结直肠癌的化学预防；2)利用糖蛋白组学方法开发和验证用于胰腺癌和结直肠癌早期检测的生物标记物；3)定向抑制Chk1作为减少辐射导致的胰腺癌损伤修复的机制；以及4)通过定向抑制ATDC以减少DNA损伤反应来改进胰腺癌的治疗。这些主要的转换项目得到职业发展和发展研究计划的补充，这些计划确定了结直肠癌和胰腺癌的新的风险评估、预防和治疗目标。所有孢子研究将得到三个核心资源(行政、生物统计和信息学以及生物样本)的支持。该孢子是密歇根大学综合癌症中心的一个完整组成部分。该孢子还被整合到密歇根大学临床与健康研究所，这是医学院和健康科学校园的一个新的翻译研究资源。该孢子整合了其他孢子项目，并将国家孢子项目与其他国家癌症研究资源联系起来，如早期发现研究网络和西南肿瘤学小组。Gl Sporate将重点放在对其翻译研究计划进行严格的科学审查，基础和临床研究人员配对，利用不同科学家的专业知识，并利用灵活性为有前途的新研究方法提供资金。我们多学科研究小组的相互作用使密歇根大学综合癌症中心的Gl孢子比其单个部分的总和更大。

DESCRIPTION (provided by applicant): A Specialized Program of Research Excellence (SPORE) entitled "Translational Research in Gl Cancer" is proposed to tap the vast intellectual and physical resources of the University of Michigan to decrease the morbidity and mortality from pancreatic and colorectal cancers. The SPORE will address the hypothesis that identifying and developing interventions to address molecular events that enhance cellular carcinogenesis or cellular transformed phenotype will reduce the morbidity and mortality associated with colorectal and pancreatic cancers through risk identification, preventive interventions, early detection, or improved treatment of invasive cancer. This integrated translational research program consists of four major projects that explore 1) fish oil intervention as a chemopreventive for colorectal cancer; 2) development and validation of biomarkers for the early detection of pancreatic and colorectal cancer using glycoproteomics methods; 3) targeted inhibition of Chk1 as a mechanism to reduce repair of radiation induced damage to pancreatic cancer; and 4) improved treatment of pancreatic cancer through targeted inhibition of ATDC to reduce DNA damage response. These major translational projects are complemented by Career Development and Developmental Research Programs that identify new risk assessment, preventive and treatment targets for colorectal and pancreatic cancers. All SPORE studies will be supported by three Core Resources (Administrative, Biostatistics and Informatics, and Biosample). The SPORE is a fully integrated component of the University of Michigan Comprehensive Cancer Center. The SPORE is also integrated into the University of Michigan's Institute for Clinical and Health Research, a new translational research resource for the Medical School and Health Sciences Campus. The SPORE integrates other SPORE programs and links the National SPORE program to other national cancer research resources such as the Early Detection Research Network and the Southwest Oncology Group. This Gl SPORE places premiums on rigorous scientific review of its translational research programs, pairing of basic and clinical investigators, drawing on the expertise of diverse scientists, and utilizing flexibility to fund promising new research approaches. The interaction of our multidisciplinary group of investigators makes the Gl SPORE at the University of Michigan Comprehensive Cancer Center greater than the sum of its individual parts.