Translational Research in GI Cancer

描述（由申请人提供）：提出了一项名为“GI癌症转化研究”的卓越研究专业计划（SPORE），以利用密歇根大学的大量智力和物质资源来降低胰腺癌和结肠直肠癌的发病率和死亡率。SPORE将解决以下假设：识别和开发干预措施以解决增强细胞致癌或细胞转化表型的分子事件，将通过风险识别、预防干预、早期检测或改善浸润性癌症的治疗来降低与结直肠癌和胰腺癌相关的发病率和死亡率。该综合转化研究计划包括四个主要项目，探索1）鱼油干预作为结直肠癌的化学预防; 2）使用糖蛋白质组学方法开发和验证用于胰腺癌和结直肠癌早期检测的生物标志物; 3）靶向抑制Chk 1作为减少胰腺癌辐射诱导损伤修复的机制; 4）使用鱼油干预作为结直肠癌的化学预防; 5）使用糖蛋白质组学方法开发和验证生物标志物。和4）通过靶向抑制ATDC以减少DNA损伤反应来改善胰腺癌的治疗。这些主要的转化项目由职业发展和发展研究计划补充，这些计划确定了结直肠癌和胰腺癌的新风险评估，预防和治疗目标。所有SPORE研究将由三个核心资源（管理、生物统计学和信息学以及生物样品）提供支持。SPORE是密歇根大学综合癌症中心的一个完全集成的组成部分。SPORE还整合到密歇根大学的临床和健康研究所，这是医学院和健康科学校区的一个新的转化研究资源。SPORE整合了其他SPORE计划，并将国家SPORE计划与其他国家癌症研究资源（如早期检测研究网络和西南肿瘤学组）联系起来。该Gl SPORE重视对其转化研究项目进行严格的科学审查，将基础和临床研究人员配对，利用不同科学家的专业知识，并利用灵活性资助有前途的新研究方法。我们多学科研究小组的相互作用使密歇根大学综合癌症中心的GI孢子大于其各个部分的总和。

DESCRIPTION (provided by applicant): A Specialized Program of Research Excellence (SPORE) entitled "Translational Research in Gl Cancer" is proposed to tap the vast intellectual and physical resources of the University of Michigan to decrease the morbidity and mortality from pancreatic and colorectal cancers. The SPORE will address the hypothesis that identifying and developing interventions to address molecular events that enhance cellular carcinogenesis or cellular transformed phenotype will reduce the morbidity and mortality associated with colorectal and pancreatic cancers through risk identification, preventive interventions, early detection, or improved treatment of invasive cancer. This integrated translational research program consists of four major projects that explore 1) fish oil intervention as a chemopreventive for colorectal cancer; 2) development and validation of biomarkers for the early detection of pancreatic and colorectal cancer using glycoproteomics methods; 3) targeted inhibition of Chk1 as a mechanism to reduce repair of radiation induced damage to pancreatic cancer; and 4) improved treatment of pancreatic cancer through targeted inhibition of ATDC to reduce DNA damage response. These major translational projects are complemented by Career Development and Developmental Research Programs that identify new risk assessment, preventive and treatment targets for colorectal and pancreatic cancers. All SPORE studies will be supported by three Core Resources (Administrative, Biostatistics and Informatics, and Biosample). The SPORE is a fully integrated component of the University of Michigan Comprehensive Cancer Center. The SPORE is also integrated into the University of Michigan's Institute for Clinical and Health Research, a new translational research resource for the Medical School and Health Sciences Campus. The SPORE integrates other SPORE programs and links the National SPORE program to other national cancer research resources such as the Early Detection Research Network and the Southwest Oncology Group. This Gl SPORE places premiums on rigorous scientific review of its translational research programs, pairing of basic and clinical investigators, drawing on the expertise of diverse scientists, and utilizing flexibility to fund promising new research approaches. The interaction of our multidisciplinary group of investigators makes the Gl SPORE at the University of Michigan Comprehensive Cancer Center greater than the sum of its individual parts.