Mentoring Translational Research in HIV

描述（由申请人提供）：虽然继续取得重大进展，但不太可能很快研制出安全有效的艾滋病毒治疗方法或疫苗。这些目标的成功将取决于未来的艾滋病毒研究人员，其中许多人可能在未来5到10年内接受培训。这项K24提案的目标是为申请人提供足够的支持，指导受训者进行最先进的转化和以患者为导向的艾滋病毒研究，并扩大他对加州大学圣地亚哥分校广泛的培训项目的参与。该应用程序建立在资助的、活跃的和正在进行的研究项目的基础上，在这些项目中，学员是主要的领导者，并在研究设计、执行、分析、结果解释和发表的各个方面接受培训。提出的研究提供了机会，深入指导和调查重要的和开放的科学问题，在艾滋病毒的发病机制。这些目标将在以下三个目标中实现，其中包括多个临床研究和六名当前学员。特异性目的1：通过调查生殖道（1A）、肠道相关淋巴组织（1B）和血液中的中和抗体反应（1C），确定原发性HIV感染期间的病毒学和免疫动力学。具体目标2：在资源有限的环境中验证用于诊断目的的汇集方法，以检测：抗逆转录病毒治疗的病毒学失败（2A）和艾滋病感染环境中的亚急性疟疾感染（2B）。具体目标3：使用分子流行病学方法表征圣地亚哥和蒂华纳之间的HIV-1传播网络。综上所述，该提案将允许处于职业生涯中期的申请人继续并扩大他的艾滋病毒研究和指导活动。

DESCRIPTION (provided by applicant): While significant progress continues to be made, it is not likely that a safe and effective cure or vaccine for HIV will be developed soon. The success of these goals will depend on future HIV researchers, many of whom are likely to be trained in the next five to ten years. The goal of this K24 proposal is to provide the applicant with sufficiet support to mentor trainees in state-of-the-art translational and patient oriented HIV research and to expand his involvement in UCSD's wide array of training programs. This application is built upon funded, active and ongoing research projects, where the mentee is the primary leader and is trained in every aspect of study design, execution, analyses, results interpretation and publication. The presented studies provide opportunities for in-depth mentoring as well as investigation into important and open scientific questions in HIV pathogenesis. These goals will be met in the following three aims, which incorporate multiple clinical studies and six current mentees. SPECIFIC AIM 1: To determine virologic and immunologic dynamics during primary HIV infection by investigating: the genital tract (1A), gut associated lymphoid tissue (1B), and the neutralizing antibody response in the blood (1C). SPECIFIC AIM 2: To validate pooling methods for diagnostic purposes in resource limited settings to detect: virologic failure of antiretroviral therapy (2A) and sub-acute malaria infection in the setting of HIV infection (2B). SPECIFIC AIM 3: To use molecular epidemiologic methods to characterize HIV-1 transmission networks between San Diego and Tijuana. Taken together, this proposal will allow the mid-career applicant to continue and expand his HIV research and mentoring activities.