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Photophobia during migraine: sensory, autonomic and emotional responses to light

偏头痛期间的畏光：对光的感觉、自主和情绪反应

基本信息

批准号：
8694112
负责人：
Rami Burstein
金额：
$ 43.07万
依托单位：
BETH ISRAEL DEACONESS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-01 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8694112
关键词：
Affective Animal Experimentation Animals Anxiety Applications Grants Area Attention Brain Brain Stem Brain region Cell Nucleus Cephalic Clinical Clinical Research Color Color blindness Cone Control Groups Crying Data Analyses Development Diagnosis Dizziness Documentation Dura Mater Educational process of instructing Electroretinography Emotional Emotions Environment Exposure to FDA approved Functional disorder Future Goals Head Headache Hearing Human Hypothalamic structure Individual Light Mediating Medicine Migraine Molecular Myalgia Nausea Nervous System Physiology Neural Pathways Neurologic Neurons Neurosciences Neurosecretory Systems Night Blindness Nociception Optic Nerve Pain Pain-Free Panic Pathway interactions Patients Perception Photophobia Physiological Play Psychophysics Reaction Research Retina Retinal Degeneration Retinitis Pigmentosa Role Sensory Signal Transduction Site Spinal Cord Structure of trigeminal nerve spinal tract nucleus Sweat Sweating Symptoms Techniques Testing Vertebrate Photoreceptors Visual evoked cortical potential Visual impairment base blind emotional reaction human study human subject insight migration neuromechanism novel novel strategies novel therapeutics prevent response retinal rods transmission process

项目摘要

DESCRIPTION (provided by applicant): The broad objective of this application is to identify neural mechanisms that cause migraineurs to seek sanctuary in the dark during attacks in effort to escape what they describe as "my head hurts more and I feel worse when I am exposed to light". The long-term objectives are to identify the impact of light on sensory, affective and autonomic neurological functions during migraine (human study), and discover the neural pathways through which lights alter these functions (animal study). Leading up to this grant proposal are years of listening to patients' testimonies which taught us that exposure to different kind of lights can trigger different symptoms in migraineurs with normal eyesight as compared to blind and color-blind migraineurs. Based on what we heard, we postulated that exacerbation of headache by light is one of many reasons why migraineus seek the dark during migraine and that different colors of lights have the capacity to trigger different neurological symptoms. Mechanistically, we hypothesized that during migraine, activity of neurons in brain regions that mediate different aspects of sensory, emotional, and autonomic responses to pain is modulated by both headache and light through signals transmitted to them from the spinal trigeminal nucleus and the optic nerve. In the clinical study, we will determine the effects of different colos of light on the intensity of migraine headache and its many associated symptoms. Two groups of migraineurs (normal eyesight and visually-impaired) and a control group will be expose to different intensities of white, blue, green, yellow and red lights (delivered through an FDA-approved photic stimulator) when they are pain-free and during an attack. Data analysis and interpretation will include strength of electroretinography and visual evoked potential signals (waveforms) as well as documentation of sensory, affective and physiological changes. In the animal study, we will determine whether neurons that play a role in the neurological symptoms that are altered by light in patients receive direct input from the retina and brain areas involved in the transmission of migraine headache. These studies will combine psychophysical observations in human subjects with tract-tracing, immunohistochemical, molecular and physiological techniques in animals.

描述（由申请人提供）：本申请的主要目的是确定导致偏头痛患者在发作时在黑暗中寻求庇护的神经机制，以逃避他们所描述的“当我暴露在光线下时，我的头更疼，我感觉更糟”。长期目标是确定偏头痛期间光线对感觉、情感和自主神经功能的影响（人类研究），并发现光线改变这些功能的神经通路（动物研究）。在提出这项拨款申请之前，我们多年来一直在倾听病人的证词，这些证词告诉我们，接触不同的