Clinical Core

临床核心的目标是优化和支持由CORT研究者承担的项目，增强实验室之间的跨学科研究能力，并以有意义的方式加快人类受试者的研究。临床核心将提供前瞻性随访、特征明确的干燥综合征（SS）患者队列，用于CORT和其他使用者。它还将为寻找和招募特定类型的干燥综合征患者和/或对照CORT研究提供帮助。将收集登记患者的大量临床和人口统计数据，并将其记录到现有的数据库中。还将提供复杂水平的初始样品处理（如分离血清、血浆、DNA、RNA、细胞亚群、唾液腺活检等）。通过组织和管理

The goals of the Clinical Core are to optimize and support projects undertaken by the CORT Investigators, to enhance interdisciplinary research capabilities between laboratories, and to expedite human subjects research in a meaningful way. The Clinical Core will provide access to prospectively followed, well-characterized cohorts of Sjogren's Syndrome (SS) patients for CORT Jnvetlgators and other users. It will also provide help in finding and recruiting specified types of Sjogren's Syndrome patients and/or controls for CORT studies. Extensive clinical and demographic data on enrolled patients will be collected and recorded into an existing database. A sophisticated level of initial sample processing will also be provided (such as isolating serum, plasma, DNA, RNA, cell subsets, salivary gland biopsies, etc). By organizing and managing the large numbers of samples and extensive data that will need to be mobilized for these projects, this Core will help ensure success of the Oklahoma Sjogren's Syndrome Center of Research Translation (OSSCORT). The Clinical Core will be an integrated part of the research team, providing help with clinical study design, sample and data management and regulatory support. The specific goals of the Clinical Core include: 1. Facilitate human subject consent, recruitment and compliance. This includes consenting recruiting and obtaining samples from SS patients and controls for CORT projects, and assisting with regulatory reporting. The Clinical Core will also provide detailed clinical information as needed for each project. 2. Facilitate access to human samples and clinical data for research purposes. This goal includes serving as a central resource for CORT investigators to design human studies, and obtain appropriately collected, processed, and stored DNA, serum, cells, salivary gland biopsies, clinical and/or de-identifed data.