Clinical Research Core

临床研究核心

• 批准号: 10218194
• 负责人: Robert Hal Scofield
• 金额: $ 61.79万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10218194
• 关键词: Address; Adopted; American; American Indians; Arthritis; Autoimmune Diseases; Autoimmunity; Award; Back; Blood; Cardiovascular Diseases; Certification; Cherokee Indian; Chronic; Cities; Clinical; Clinical Data; Clinical Research; Clinical Trials; Clinical Trials Data Monitoring Committees; Collaborations; Collection; Communities; Contract Services; Contracts; Data; Degenerative polyarthritis; Diabetes Mellitus; Doctor of Philosophy; Ensure; Evaluation; Funding; Grant; Growth; Health; Healthcare; Human; Human Resources; Human Subject Research; Individual; Infrastructure; Institutes; Institution; Institutional Review Boards; K-Series Research Career Programs; Life Expectancy; Location; Malignant Neoplasms; Mediation; Medical; Medical center; Mission; Obesity; Oklahoma; Participant; Pathologist; Patient Recruitments; Patients; Pediatrics; Phase; Play; Population; Process; Protocols documentation; Publications; Registries; Reproducibility; Research; Research Personnel; Research Project Grants; Resources; Review Committee; Role; Running; Rural; Sampling; Sampling Studies; Site; System; Translating; Translational Research; Tribes; Underrepresented Minority; United States Department of Veterans Affairs; United States Indian Health Service; Work; base; biobank; career; cohort; college; cost effective; dissemination research; healthy aging; human subject; implementation research; improved; innovation; member; minority communities; novel; obesity in children; population health; program dissemination; programs; recruit; repository; research facility; research study; sample collection; success; translational research program; tribal community; volunteer

Although some improvement has been seen between initiation of the Oklahoma Shared Clinical and Translational Resources (OSCTR) and today (moving from 49th to 46th in rankings), Oklahoma is consistently in or near the bottom 10% of states for the overall health of its population. The residents of the state disproportionately suffer from chronic health problems, such as obesity, diabetes, cardiovascular disease, and arthritis/autoimmunity. Oklahomans have a life-expectancy which is 3 years shorter than the average US citizen and American Indians have a life-expectancy which is 7.3 years shorter than other groups within the US. With high percentages of rural (38%) and tribal (9%) populations, Oklahoma has unique challenges and opportunities to implement clinical and translational research (CTR) projects and dissemination and implementation research to improve health and health care. The Clinical Resources (CR) Core of the OSCTR has built a centralized system to support human subjects research in the state that has prioritized its focus on these issues. The Core provides clinical research facilities and a CAP-certified Biorepository that has allowed the OSCTR to adopt or establish registries, repositories, and cohorts to assist investigators to obtain and utilize high-quality samples to support their research efforts. This effort has allowed the Core to provide more than 95,000 clinical samples and more than 1.6 million data fields in the first four years of the award. This support has launched the careers of multiple CTR investigators, including researchers that are members of the under- represented minority communities in the state. The CR Core will continue to provide this invaluable access to sample collections while supporting the establishment of new repositories focusing on the health issues of greatest concerns to our populations, including cancer, diabetes and osteoarthritis. The CR core is also expanding the capabilities of its Clinical Research Units by new innovative partnerships with the Oklahoma Blood Institute and Oklahoma City Veterans Affairs Medical Center. This will enhance the overall opportunities of our CTR investigators to recruit participants into research studies as well as provide new capabilities to translate research findings and effect population health through partners that interact with a large number of previously unreached Oklahoma residents. Through the CR Core, the OSCTR is establishing a formal Regulatory Assistance Unit to provide a centralized location for OSCTR Investigators to seek assistance with institutional IRB applications, protocols, data safety monitoring boards and other regulatory requirements. This Unit will work with the Administrative Core to make access to resources and information more accessible to investigators, clinicians, clinical research staff and participants through the new Gateway to Oklahoma portal. This unit will work closely with the OSCTR Tribal Engagement Unit to help investigators to work with the Indian Health Service and tribal IRBs ensure the protection of both individual human subjects and tribal community populations.

尽管在俄克拉荷马州共享临床和 翻译资源（OSCTR）和今天（从排名第49位移至第46位），俄克拉荷马州一直处于 或在其人口总体健康状况的最底层附近。国家居民 不成比例地遭受慢性健康问题，例如肥胖，糖尿病，心血管疾病和 关节炎/自身免疫性。俄克拉荷马人的寿命比普通我们的平均水平短3年 公民和美洲印第安人的生活期望比其他群体短7.3岁。 我们。俄克拉荷马州的农村地区（38％）和部落人口（9％）的人口占据了独特的挑战，并且 实施临床和转化研究（CTR）项目和传播的机会 实施研究以改善健康和卫生保健。 OSCTR的临床资源（CR）核心 已经建立了一个集中式系统，以支持该州的人类受试者的研究，该研究优先考虑其关注 这些问题。该核心提供临床研究设施和获得帽认证的生物座席，已允许 OSCTR采用或建立注册机构，存储库和同伙，以协助调查人员获取和利用 高质量的样本以支持他们的研究工作。这项工作使核心提供了超过 该奖项的前四年中有95,000个临床样本和超过160万个数据字段。这个支持 已经启动了多个CTR调查人员的职业，包括研究人员 代表该州的少数民族社区。 CR核心将继续提供此无价的访问 样本收集的同时支持建立新的存储库，重点是 对我们的人群的最大关注，包括癌症，糖尿病和骨关节炎。 CR核心也是 通过与俄克拉荷马州的新创新合作伙伴关系扩大其临床研究单位的能力 血液研究所和俄克拉荷马城退伍军人事务医疗中心。这将增强整体机会 我们的CTR调查人员将参与者招募参与研究，并提供新的功能 通过与大量互动的合作伙伴翻译研究结果并影响人群健康 以前未接触的俄克拉荷马州居民。通过CR核心，OSCTR正在建立正式 监管援助部门为OSCTR调查人员提供集中地点，以寻求协助 机构IRB申请，协议，数据安全监控板和其他监管要求。这 单位将与管理核心合作，以使获取资源和信息更容易访问 调查人员，临床医生，临床研究人员和参与者通过通往俄克拉荷马州门户的新门户。 该部门将与OSCTR部落参与部门紧密合作，以帮助调查人员与印度人合作 卫生服务和部落IRB确保保护个人人类和部落社区 人群。