Clinical Research Core

临床研究核心

• 批准号: 10218194
• 负责人: Robert Hal Scofield
• 金额: $ 61.79万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10218194
• 关键词: Address; Adopted; American; American Indians; Arthritis; Autoimmune Diseases; Autoimmunity; Award; Back; Blood; Cardiovascular Diseases; Certification; Cherokee Indian; Chronic; Cities; Clinical; Clinical Data; Clinical Research; Clinical Trials; Clinical Trials Data Monitoring Committees; Collaborations; Collection; Communities; Contract Services; Contracts; Data; Degenerative polyarthritis; Diabetes Mellitus; Doctor of Philosophy; Ensure; Evaluation; Funding; Grant; Growth; Health; Healthcare; Human; Human Resources; Human Subject Research; Individual; Infrastructure; Institutes; Institution; Institutional Review Boards; K-Series Research Career Programs; Life Expectancy; Location; Malignant Neoplasms; Mediation; Medical; Medical center; Mission; Obesity; Oklahoma; Participant; Pathologist; Patient Recruitments; Patients; Pediatrics; Phase; Play; Population; Process; Protocols documentation; Publications; Registries; Reproducibility; Research; Research Personnel; Research Project Grants; Resources; Review Committee; Role; Running; Rural; Sampling; Sampling Studies; Site; System; Translating; Translational Research; Tribes; Underrepresented Minority; United States Department of Veterans Affairs; United States Indian Health Service; Work; base; biobank; career; cohort; college; cost effective; dissemination research; healthy aging; human subject; implementation research; improved; innovation; member; minority communities; novel; obesity in children; population health; program dissemination; programs; recruit; repository; research facility; research study; sample collection; success; translational research program; tribal community; volunteer

Although some improvement has been seen between initiation of the Oklahoma Shared Clinical and Translational Resources (OSCTR) and today (moving from 49th to 46th in rankings), Oklahoma is consistently in or near the bottom 10% of states for the overall health of its population. The residents of the state disproportionately suffer from chronic health problems, such as obesity, diabetes, cardiovascular disease, and arthritis/autoimmunity. Oklahomans have a life-expectancy which is 3 years shorter than the average US citizen and American Indians have a life-expectancy which is 7.3 years shorter than other groups within the US. With high percentages of rural (38%) and tribal (9%) populations, Oklahoma has unique challenges and opportunities to implement clinical and translational research (CTR) projects and dissemination and implementation research to improve health and health care. The Clinical Resources (CR) Core of the OSCTR has built a centralized system to support human subjects research in the state that has prioritized its focus on these issues. The Core provides clinical research facilities and a CAP-certified Biorepository that has allowed the OSCTR to adopt or establish registries, repositories, and cohorts to assist investigators to obtain and utilize high-quality samples to support their research efforts. This effort has allowed the Core to provide more than 95,000 clinical samples and more than 1.6 million data fields in the first four years of the award. This support has launched the careers of multiple CTR investigators, including researchers that are members of the under- represented minority communities in the state. The CR Core will continue to provide this invaluable access to sample collections while supporting the establishment of new repositories focusing on the health issues of greatest concerns to our populations, including cancer, diabetes and osteoarthritis. The CR core is also expanding the capabilities of its Clinical Research Units by new innovative partnerships with the Oklahoma Blood Institute and Oklahoma City Veterans Affairs Medical Center. This will enhance the overall opportunities of our CTR investigators to recruit participants into research studies as well as provide new capabilities to translate research findings and effect population health through partners that interact with a large number of previously unreached Oklahoma residents. Through the CR Core, the OSCTR is establishing a formal Regulatory Assistance Unit to provide a centralized location for OSCTR Investigators to seek assistance with institutional IRB applications, protocols, data safety monitoring boards and other regulatory requirements. This Unit will work with the Administrative Core to make access to resources and information more accessible to investigators, clinicians, clinical research staff and participants through the new Gateway to Oklahoma portal. This unit will work closely with the OSCTR Tribal Engagement Unit to help investigators to work with the Indian Health Service and tribal IRBs ensure the protection of both individual human subjects and tribal community populations.

尽管在俄克拉荷马州共享临床和 翻译资源（OSCTR）和今天（排名从第49位上升到第46位），俄克拉荷马州一直在 或接近最低的10%的国家的整体健康的人口。本州居民 不成比例地患有慢性健康问题，如肥胖症、糖尿病、心血管疾病， 关节炎/自身免疫。俄克拉荷马州人的预期寿命比美国平均短3年 美国公民和美国印第安人的预期寿命比美国其他群体短7.3年。 我们俄克拉荷马州的农村人口（38%）和部落人口（9%）比例很高，因此面临着独特的挑战， 实施临床和转化研究（CTR）项目和传播的机会， 实施研究，以改善健康和保健。OSCTR的临床资源（CR）核心 建立了一个集中的系统，以支持该州的人类受试者研究，该系统优先关注 这些问题核心提供临床研究设施和CAP认证的生物储存库， OSCTR采用或建立登记处、储存库和队列，以协助研究者获取和利用 高质量的样品来支持他们的研究工作。这一努力使核心小组能够提供超过 95,000个临床样本和超过160万个数据字段在前四年的奖项。这种支持 已经启动了多个CTR研究人员的职业生涯，包括研究人员是下- 代表了该州的少数民族社区。CR核心将继续提供这种宝贵的访问， 样本收集，同时支持建立新的储存库，重点关注 我们的人口面临的最大问题是癌症、糖尿病和骨关节炎。CR核心也是 通过与俄克拉荷马州建立新的创新伙伴关系，扩大其临床研究单位的能力 血液研究所和俄克拉荷马州市退伍军人事务医疗中心。这将提高整体的机会 我们的CTR研究人员招募参与者进行研究，并提供新的能力， 通过与大量的研究人员互动的合作伙伴，转化研究成果， 以前未到达的俄克拉荷马州居民。通过CR核心，OSCTR正在建立一个正式的 监管援助股为OSCTR调查人员提供一个集中的地点，以寻求以下方面的援助 机构IRB申请、方案、数据安全监测委员会和其他监管要求。这 该股将与行政核心合作， 研究人员、临床医生、临床研究人员和参与者通过新的俄克拉荷马州门户网站进行交流。 该股将与OSCTR部落接触股密切合作，帮助调查人员与印第安人合作， 卫生服务和部落IRB确保保护个体人类受试者和部落社区 人口。