Clinical Research Core

尽管在俄克拉荷马州共享临床计划的启动和 翻译资源(OSCTR)和今天(排名从第49位上升到第46位)，俄克拉荷马州一直处于 或接近倒数10%的州的总体人口健康。该州的居民 不成比例地遭受慢性健康问题，如肥胖、糖尿病、心血管疾病和 关节炎/自身免疫性。俄克拉荷马州人的平均寿命比美国人的平均寿命短3年 公民和美国印第安人的预期寿命比美国其他群体短7.3岁 我们。俄克拉荷马州农村人口(38%)和部落人口(9%)的比例很高，面临着独特的挑战和 有机会实施临床和转化性研究(CTR)项目并传播和 开展改善健康和医疗保健的实施研究。口腔鳞状细胞癌的临床资源(CR)核心 已经建立了一个集中的系统来支持该州的人类受试者研究，并将重点放在 这些问题。该中心提供临床研究设施和CAP认证的生物信息库，使 OSCTR通过或建立登记处、储存库和队列，以协助调查人员获取和利用 高质量的样品，以支持他们的研究努力。这一努力使核心提供的不仅仅是 在该奖项的前四年中，有95,000个临床样本和160多万个数据字段。这一支持 已经启动了多个CTR调查人员的职业生涯，包括作为Under- 代表该州的少数族裔社区。CR Core将继续提供这一宝贵的访问权限 收集样本，同时支持建立新的储存库，重点关注健康问题 我们人民最关切的问题，包括癌症、糖尿病和骨性关节炎。CR核心也是 通过与俄克拉荷马大学建立新的创新伙伴关系来扩大其临床研究部门的能力 血液研究所和俄克拉何马城退伍军人事务医疗中心。这将增加整体机会 我们的CTR调查人员招募参与者进行研究，并提供新的能力来 翻译研究结果并通过与大量 以前未被联系到的俄克拉何马州居民。通过CR核心，OSCTR正在建立一个正式的 监管援助股，为OSCTR调查员提供一个集中地点，以寻求协助 机构IRB应用、协议、数据安全监控板和其他监管要求。这 该股将与行政核心合作，使下列人员更容易获得资源和信息 研究人员、临床医生、临床研究人员和参与者通过新的通往俄克拉何马州的门户网站。 该股将与OSCTR部落接触股密切合作，帮助调查人员与印第安人合作 保健服务和部落IRBs确保对人类个体和部落社区的保护 人口。

Although some improvement has been seen between initiation of the Oklahoma Shared Clinical and Translational Resources (OSCTR) and today (moving from 49th to 46th in rankings), Oklahoma is consistently in or near the bottom 10% of states for the overall health of its population. The residents of the state disproportionately suffer from chronic health problems, such as obesity, diabetes, cardiovascular disease, and arthritis/autoimmunity. Oklahomans have a life-expectancy which is 3 years shorter than the average US citizen and American Indians have a life-expectancy which is 7.3 years shorter than other groups within the US. With high percentages of rural (38%) and tribal (9%) populations, Oklahoma has unique challenges and opportunities to implement clinical and translational research (CTR) projects and dissemination and implementation research to improve health and health care. The Clinical Resources (CR) Core of the OSCTR has built a centralized system to support human subjects research in the state that has prioritized its focus on these issues. The Core provides clinical research facilities and a CAP-certified Biorepository that has allowed the OSCTR to adopt or establish registries, repositories, and cohorts to assist investigators to obtain and utilize high-quality samples to support their research efforts. This effort has allowed the Core to provide more than 95,000 clinical samples and more than 1.6 million data fields in the first four years of the award. This support has launched the careers of multiple CTR investigators, including researchers that are members of the under- represented minority communities in the state. The CR Core will continue to provide this invaluable access to sample collections while supporting the establishment of new repositories focusing on the health issues of greatest concerns to our populations, including cancer, diabetes and osteoarthritis. The CR core is also expanding the capabilities of its Clinical Research Units by new innovative partnerships with the Oklahoma Blood Institute and Oklahoma City Veterans Affairs Medical Center. This will enhance the overall opportunities of our CTR investigators to recruit participants into research studies as well as provide new capabilities to translate research findings and effect population health through partners that interact with a large number of previously unreached Oklahoma residents. Through the CR Core, the OSCTR is establishing a formal Regulatory Assistance Unit to provide a centralized location for OSCTR Investigators to seek assistance with institutional IRB applications, protocols, data safety monitoring boards and other regulatory requirements. This Unit will work with the Administrative Core to make access to resources and information more accessible to investigators, clinicians, clinical research staff and participants through the new Gateway to Oklahoma portal. This unit will work closely with the OSCTR Tribal Engagement Unit to help investigators to work with the Indian Health Service and tribal IRBs ensure the protection of both individual human subjects and tribal community populations.