COBRE III: Center for Cardiovascular Research

描述(由申请人提供)：我们正在提交夏威夷大学心血管生物医学研究卓越中心(COBRE)的续签申请，以回应美国国立卫生研究院PAR-10-196。约翰·A·伯恩斯医学院建立了一个心血管研究中心(OCR)，由R01资助的分子心脏病专家Ralph Shohet博士领导。在NCRR通过前两个资金周期对我们中心进行投资期间，我们的初级调查人员除了NSF、AHA和当地慈善基金外，还成功地竞争了6架新的R01和3架R21。在过去的五年里，我们利用机构和科布雷的支持相结合的方式，为我们的项目招聘了两名高级教员和三名初级教员。我们还建立了三个核心实验室，为现代生物医学科学提供关键服务，分别是基因组学、组织病理学和小鼠生理学。这些成就实现了心血管科布雷计划的最初目标，即加强医学院和大学的生物医学研究能力，并增强我们的研究人员竞争独立外部资金的能力。我们计划在前两个Cobre周期的成功基础上，加强这些核心设施，并将它们置于安全和可持续的财务基础上，以便它们能够继续支持我们机构的生物医学研究。我们的长期目标是继续培训和支持技术熟练的研究人员队伍，他们的研究最终将减少心脏病，消除夏威夷不同种族群体，特别是夏威夷原住民之间的心血管健康差距。 我们的两个具体目标是：1.保持核心服务的增长并增强其可持续性，2.制定一个试点项目计划，为我们研究人员的最佳想法提供资金，使他们在外部支持方面具有竞争力。

DESCRIPTION (provided by applicant): We are submitting this renewal application for the Cardiovascular Center of Biomedical Research Excellence (COBRE) at the University of Hawaii (UH) in response to the National Institutes of Health PAR-10-196. The John A. Burns School of Medicine has established a Center for Cardiovascular Research (OCR), led by Dr. Ralph Shohet, an R01-funded molecular cardiologist. During the NCRR's investment in our Center through two previous cycles of funding, our junior investigators have successfully competed for 6 new R01s and 3 R21s, in addition to NSF, AHA, and local philanthropic funding. During the past five years we recruited two senior faculty and 3 junior faculty to our program using a combination of institutional and COBRE support. We have also established three Core laboratories that provide crucial services for modern biomedical science, in Genomics, Histopathology, and Mouse Physiology. These accomplishments fulfill the initial goals of the Cardiovascular COBRE program to strengthen the biomedical research capacity of the Medical School and the University and enhance the ability of our investigators to compete for independent extramural funding. We plan to build upon the success of the first two COBRE cycles by enhancing these core facilities and placing them on a secure and sustainable financial basis, so that they can continue to support biomedical research at our institution. Our long-term goal is to continue to train and support the cadre of skilled researchers whose studies will ultimately reduce heart disease and eliminate cardiovascular health disparities among the diverse ethnic groups of Hawaii, particularly Native Hawaiians. Our two specific aims are: 1. to maintain the growth and enhance the sustainability of Core services, and 2. to develop a pilot project program that will fund the best ideas of our investigators to the point where they are competitive for extramural support.