Developmental Psychopathology of Restrictive and Binge Eating in Childhood

应聘者：我是北卡罗来纳大学教堂山分校精神病学系饮食失调项目的研究助理教授。我接受过发育精神病理学和饮食失调方面的培训。我正在寻求儿童饮食放松管制、精神遗传学、纵向数据分析和蛋白质组方法论方面的培训。职业目标：我的最终目标是定义前驱进食障碍--在进食障碍出现之前出现的早期迹象和症状--并开发一种预测儿童进食障碍风险的算法。检测前驱进食障碍的转化科学可能有可能通过早期干预改变发育轨迹来预防后来的进食障碍。职业发展：我计划在四个领域培养我的技能和专业知识：1.童年时期饮食失调；2.精神遗传学，包括开发多基因风险指数；3.纵向数据分析，包括潜在轨迹建模；4.前驱症状理论、方法和协作研究。研究项目：拟议的项目利用现有资源，利用以前从挪威母婴研究(MOBA)收集的数据，这是一项纵向前瞻性出生队列研究和生物库，涉及约110,000名挪威儿童及其母亲。首先，我将绘制从18个月到8岁儿童限制饮食的发展轨迹图，并测试8岁儿童限制饮食的路径模型(例如，避免食物和情绪上的低估，愤怒或焦虑时吃得更少)。其次，我将绘制36个月到8岁儿童暴饮暴食的发展轨迹图，并测试8岁儿童暴饮暴食的路径模型(例如，在短时间内吃大量食物，经历对饮食的失控，并产生无法停止进食的印象)。第三，我将研究增加神经性厌食症多基因风险指数的影响，以告知患有和不患有神经性厌食症母亲的孩子限制饮食的轨迹和路径模型。在未来的独立应用(R01s)中，这些结果将为多方法直接观察Moba中面临饮食障碍风险的儿童提供信息，因为他们年龄增长到青春期，这是饮食障碍发病的最大风险时期。环境：研究和培训将在北卡罗来纳大学教堂山的精神病学系进行，并在挪威公共卫生研究所进行额外培训。导师：导师团队包括首席导师，心理学家辛西娅·布利克博士，国际公认的进食障碍研究和治疗专家，以及共同导师，精神病学家和精神病学遗传学方面的领先专家帕特里克·沙利文博士。Dr。 伊莱亚娜·佩林是一名儿科医生，擅长于在童年中期放松饮食管制。顾问卡里·诺斯博士是一位遗传流行病学家，他将提供整合遗传学和纵向数据分析和方法的专业知识。咨询医生Ted Reichborne-Kjennerud是一位精神病学家，也是MOBA数据集和精神病学遗传流行病学方面的专家。咨询顾问罗伯特·哈默博士是一名生物统计学家和纵向建模专家。戴安娜·珀金斯博士，顾问，精神病学家，北美前驱精神分裂症纵向研究基因组学部分的联合首席研究员。

DESCRIPTION (provided by applicant): Candidate: I am a Research Assistant Professor with the Eating Disorders Program in the Department of Psychiatry at The University of North Carolina at Chapel Hill. I have training in developmental psychopathology and eating disorders. I am seeking training in childhood deregulated eating, psychiatric genetics, longitudinal data analysis, and proteome methodology. Career Goals: My ultimate goal is to define prodromal eating disorders-early signs and symptoms that emerge before the onset of eating disorders-and develop a prognostic algorithm of eating disorder risk in children. Translational science to detect prodromal eating disorders could have the potential to prevent later eating disorders by altering developmental trajectories through early intervention. Career Development: I plan to build my skills and expertise in four areas: 1. Dysregulated eating in childhood; 2. Psychiatric genetics including the development of a polygenic risk index; 3. Longitudinal data analyses including latent trajectory modeling; and 4. Prodrome theory, methodology, and collaborative research. Research Project: The proposed project leverages existing resources by using previously collected data from the Norwegian Mother and Child Study (MoBa), a longitudinal prospective birth cohort study and biobank of ~110,000 Norwegian children and their mothers. First, I will map the developmental trajectories of restrictive eating in children from 18 months t 8 years of age and test models of pathways to 8-year-old's restrictive eating (e.g. food avoidance and emotional underrating eating less when angry or anxious). Second, I will map the developmental trajectories of binge eating in children from 36 months to 8 years of age and test models of pathways to 8-year-old's binge eating (e.g. eating large amount of food in a short period of time and experiencing loss of control over eating having the impression that one could not stop eating). Third, I will examine the impact of the addition of an anorexia nervosa polygenic risk index to inform trajectory and pathway models of children's restrictive eating in the children of mothers with and without anorexia nervosa. In future independent applications (R01s), these results will inform multi-method direct observations of the children at risk for eating disorders in MoBa as they age into adolescence, the period of greatest risk for eating disorder onset. Environment: The research and training will take place in the Department of Psychiatry at UNC Chapel Hill with additional training in the Norwegian Institute of Public Health. Mentorship: The mentorship team includes lead mentor, Dr. Cynthia Bulik, a psychologist, and internationally recognized expert in eating disorder research and treatment and co-mentor, Dr. Patrick Sullivan, a psychiatrist and leading expert in psychiatric genetics. Dr. Eliana Perrin, consultant, is a pediatrician with expertise in deregulated eating in middle childhood. Dr. Kari North, consultant, is a genetic epidemiologist and will provide expertise in integrating genetics and longitudinal data analysis and methods. Dr. Ted Reichborn-Kjennerud, consultant, is a psychiatrist and expert in the MoBa dataset and psychiatric genetic epidemiology. Dr. Robert Hamer, a consultant, is a biostatistician and expert in longitudinal modeling. Dr. Diana Perkins, consultant, is a psychiatrist and co-principal investigator of genomics component of the North American Prodrome Longitudinal Study for schizophrenia.