Developmental Psychopathology of Restrictive and Binge Eating in Childhood

描述（由申请人提供）：候选人：我是北卡罗来纳大学教堂山分校精神学系饮食失调项目的研究助理教授。我接受过发展精神病理学和饮食失调方面的培训。我正在寻求儿童饮食失调，精神遗传学，纵向数据分析和蛋白质组学方法方面的培训。职业目标：我的最终目标是定义前驱饮食失调——在饮食失调发作之前出现的早期体征和症状——并开发出儿童饮食失调风险的预测算法。检测前驱饮食失调的转化科学有可能通过早期干预改变发育轨迹来预防后来的饮食失调。职业发展：我计划在四个方面培养自己的技能和专业知识。儿童饮食失调；2. 精神病学遗传学，包括多基因风险指数的发展；3. 纵向数据分析，包括潜在轨迹建模；和4。前驱症状理论、方法和合作研究。研究项目：拟议的项目利用现有资源，使用先前从挪威母亲和儿童研究（MoBa）收集的数据，这是一项纵向前瞻性出生队列研究和约110,000名挪威儿童及其母亲的生物库。首先，我将绘制从18个月到8岁儿童限制性饮食的发展轨迹，并测试8岁儿童限制性饮食的途径模型（例如，食物回避和情绪低估，生气或焦虑时少吃）。其次，我将绘制36个月至8岁儿童暴食的发展轨迹，并测试8岁暴食的途径模型（例如，在短时间内吃大量食物，对饮食失去控制，产生无法停止进食的印象）。第三，我将检查添加神经性厌食症多基因风险指数的影响，以告知患有和不患有神经性厌食症的母亲的孩子限制性饮食的轨迹和途径模型。在未来的独立应用（R01s）中，这些结果将为多方法直接观察MoBa中饮食失调风险儿童进入青春期（饮食失调发病风险最高的时期）提供信息。环境：研究和培训将在北卡罗来纳大学教堂山分校精神病学系进行，并在挪威公共卫生研究所进行额外培训。导师：导师团队包括首席导师Cynthia Bulik博士，心理学家，国际公认的饮食失调研究和治疗专家；共同导师Patrick Sullivan博士，精神病学家，精神病学遗传学的主要专家。博士。

DESCRIPTION (provided by applicant): Candidate: I am a Research Assistant Professor with the Eating Disorders Program in the Department of Psychiatry at The University of North Carolina at Chapel Hill. I have training in developmental psychopathology and eating disorders. I am seeking training in childhood deregulated eating, psychiatric genetics, longitudinal data analysis, and proteome methodology. Career Goals: My ultimate goal is to define prodromal eating disorders-early signs and symptoms that emerge before the onset of eating disorders-and develop a prognostic algorithm of eating disorder risk in children. Translational science to detect prodromal eating disorders could have the potential to prevent later eating disorders by altering developmental trajectories through early intervention. Career Development: I plan to build my skills and expertise in four areas: 1. Dysregulated eating in childhood; 2. Psychiatric genetics including the development of a polygenic risk index; 3. Longitudinal data analyses including latent trajectory modeling; and 4. Prodrome theory, methodology, and collaborative research. Research Project: The proposed project leverages existing resources by using previously collected data from the Norwegian Mother and Child Study (MoBa), a longitudinal prospective birth cohort study and biobank of ~110,000 Norwegian children and their mothers. First, I will map the developmental trajectories of restrictive eating in children from 18 months t 8 years of age and test models of pathways to 8-year-old's restrictive eating (e.g. food avoidance and emotional underrating eating less when angry or anxious). Second, I will map the developmental trajectories of binge eating in children from 36 months to 8 years of age and test models of pathways to 8-year-old's binge eating (e.g. eating large amount of food in a short period of time and experiencing loss of control over eating having the impression that one could not stop eating). Third, I will examine the impact of the addition of an anorexia nervosa polygenic risk index to inform trajectory and pathway models of children's restrictive eating in the children of mothers with and without anorexia nervosa. In future independent applications (R01s), these results will inform multi-method direct observations of the children at risk for eating disorders in MoBa as they age into adolescence, the period of greatest risk for eating disorder onset. Environment: The research and training will take place in the Department of Psychiatry at UNC Chapel Hill with additional training in the Norwegian Institute of Public Health. Mentorship: The mentorship team includes lead mentor, Dr. Cynthia Bulik, a psychologist, and internationally recognized expert in eating disorder research and treatment and co-mentor, Dr. Patrick Sullivan, a psychiatrist and leading expert in psychiatric genetics. Dr. Eliana Perrin, consultant, is a pediatrician with expertise in deregulated eating in middle childhood. Dr. Kari North, consultant, is a genetic epidemiologist and will provide expertise in integrating genetics and longitudinal data analysis and methods. Dr. Ted Reichborn-Kjennerud, consultant, is a psychiatrist and expert in the MoBa dataset and psychiatric genetic epidemiology. Dr. Robert Hamer, a consultant, is a biostatistician and expert in longitudinal modeling. Dr. Diana Perkins, consultant, is a psychiatrist and co-principal investigator of genomics component of the North American Prodrome Longitudinal Study for schizophrenia.