Association of Acculturation with Type 2 Diabetes Risk Among US Latinos

美国拉丁裔人群文化适应与 2 型糖尿病风险的关联

• 批准号: 8710210
• 负责人: Lenny Lopez
• 金额: $ 18.6万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8710210
• 关键词: Abdomen; Acculturation; Adipose tissue; Adopted; Affect; Age; Aging; Area; Atherosclerosis; Behavior; Behavior Therapy; Behavioral; Belief; Biometry; Body Weight; Body mass index; Boston; Calcium; Cardiovascular Diseases; Caring; Characteristics; Cohort Studies; Community Health; Complex; Coronary artery; Data; Diabetes Mellitus; Diet; Disease; Environment; Epidemiology; Framingham Heart Study; Goals; Grant; Health; Health Surveys; Heart; Heterogeneity; Homeostasis; Immigrant; Incidence; Inflammation; Insulin Resistance; Latino; Literature; Measures; Mentored Patient-Oriented Research Career Development Award; Mentorship; Modeling; National Institute of Diabetes and Digestive and Kidney Diseases; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Obesity; Outcome; Physical activity; Physiological; Physiology; Population; Prevalence; Process; Publishing; Reporting; Research; Research Design; Research Personnel; Risk Factors; Socioeconomic Status; United States National Institutes of Health; Visceral; adipokines; adiponectin; cohort; cultural values; diabetes risk; experience; fasting glucose; geographic difference; health disparity; indexing; lifestyle intervention; obesity risk; patient oriented; public health relevance; skills; social; socioeconomics; subcutaneous; waist circumference

DESCRIPTION (provided by applicant): The incidence of type 2 diabetes (T2D) and its long term sequelae are increasing in the US, particularly among Latinos. Latinos are at increased risk for obesity and type 2 diabetes (T2D) and develop T2D at younger ages and at a lower body weight index compared to non-Hispanic whites. For these reasons, Latinos have been identified as a NIDDK priority population with a NIDDK research agenda that includes both biologic, socioeconomic and sociocultural factors that affect T2D prevalence and complications. Acculturation is an important socio-cultural factor that may explain the disproportionate health burden of T2D among Latinos. Acculturation is defined as the process whereby an immigrant culture adopts the beliefs and practices of a host culture. There are limited studies of T2D risk factors and acculturation and how this relationship affects intermediary T2D processes and outcomes such as incident T2D and subclinical cardiovascular disease. The association between acculturation and T2D is inconsistent among Latinos in the published literature. This grant will study the association of acculturation with T2D risk and risk factors using data from multiple well- established epidemiologic NIH cohort studies using validated multidimensional acculturation scales that capture the complex domains of cultural values, beliefs, and behaviors of the acculturation process. The 5 cohorts are: San Antonio Heart Study, Sacramento Latino Study of Aging, Boston Area Community Health Survey, Dallas Heart Study and the Framingham Heart Study Omni Cohort. The simultaneous comparison of findings will maximize the potential for exploring whether the reported heterogeneity of prior study findings is due to differences in underlying Latino cohort characteristics, geographic differences in the process of acculturation in the US and/or differences in the measure of acculturation. Dr. Lopez's long-term goal is to become an independent patient-oriented researcher in diabetes care. Aided by advanced coursework in biostatistics and social epidemiology during the K23 award period, Dr. Lopez will acquire additional research skills and experience under the mentorship of nationally and internationally known researchers in a supportive academic environment. 1

描述（由申请人提供）：2 型糖尿病 (T2D) 及其长期后遗症的发病率在美国不断增加，特别是在拉丁裔中。与非西班牙裔白人相比，拉丁裔美国人患肥胖症和 2 型糖尿病 (T2D) 的风险更高，而且患 T2D 的年龄更小，体重指数也更低。由于这些原因，拉丁裔已被确定为 NIDDK 的优先人群，NIDDK 研究议程包括影响 T2D 患病率和并发症的生物、社会经济和社会文化因素。文化适应是一个重要的社会文化因素，可以解释拉丁裔人群中 T2D 的不成比例的健康负担。文化适应被定义为移民文化接受东道国文化的信仰和实践的过程。关于 T2D 危险因素和文化适应以及这种关系如何影响中间 T2D 过程和结果（例如事件 T2D 和亚临床心血管疾病）的研究有限。在已发表的文献中，拉美裔人的文化适应与 T2D 之间的关联并不一致。这笔赠款将使用来自多个完善的流行病学 NIH 队列研究的数据，使用经过验证的多维文化适应量表来研究文化适应与 T2D 风险和风险因素的关联，这些量表捕获了文化适应过程的文化价值观、信仰和行为的复杂领域。这 5 个队列是：圣安东尼奥心脏研究、萨克拉门托拉丁裔老龄化研究、波士顿地区社区健康调查、达拉斯心脏研究和弗雷明汉心脏研究全方位队列。同时比较研究结果将最大限度地探索先前研究结果报告的异质性是否是由于拉丁裔队列特征的差异、美国文化适应过程中的地理差异和/或文化适应测量的差异造成的。洛佩兹博士的长期目标是成为糖尿病护理领域以患者为中心的独立研究人员。借助 K23 奖励期间生物统计学和社会流行病学高级课程的帮助，洛佩兹博士将在支持性学术环境中在国内外知名研究人员的指导下获得额外的研究技能和经验。 1