Small Animal BioImage

RPCI的小动物生物成像资源(沙比尔)的总体使命是提供专门的 与疾病小动物模型成像有关的服务。该资源提供了科学和 与图像采集、定量图像分析、多维渲染相关的技术服务 以及用于研究的成像数据集的可视化。沙比尔的目标是促进 RPCI的科学研究进展如下： 1.提供与非侵入性活体成像有关的必要智力和体力资源； 2.开发新的临床前成像技术，深入了解各种生物过程 参与癌症，并能够在动物身上进行实验性治疗的临床前试验 模特们， 3.建立一个技术平台，允许翻译#年评估的成像技术 改善临床疾病检测和治疗反应监测的临床前模型 竞技场。 沙比尔为调查人员提供与使用最先进的小动物成像相关的定制服务 包括磁共振成像(MRI)和光谱(MRS)、荧光蛋白等技术 成像和多光谱成像。该资源最近已扩展到包括超声波(美国)、 生物发光、光声和X射线成像服务。该资源由两名博士生教授领导， 在小动物成像方面拥有丰富的经验，并配备了额外的1.2 FTE人员，从而 运营该资源的总费用超过40年。沙比尔提供全天候访问和 以经济高效的方式向CCSG成员提供非侵入性成像技术培训。 优先使用由同行审查资助的RPCCCSG成员；第二优先考虑非同行审查-- 资助的CCSG成员；非成员和学术合作者的第三优先事项；最后的优先事项 提供给外部用户。在本报告所述期间，小动物生物成像资源提供了29项服务 来自6个研究项目的成员，CCSG成员使用同行评审资金的使用率为76%。 CCSG的支持提供了总提议预算的12%。

The overall mission of RPCI's Small Animal Bio-Imaging Resource (SABIR) is to provide specialized services relating to the imaging of small animal models of disease. The Resource provides scientific and technical services pertaining to image acquisition, quantitative image analysis, multidimensional renderings and visualization of imaging data sets for research. The objective of SABIR is to facilitate the conduct and progress of scientific research at RPCI by: 1. Providing the necessary intellectual and physical resources relating to non-invasive in vivo imaging, 2. Developing novel preclinical imaging techniques that provide insight into various biological processes involved in cancer and enable the conduct of preclinical trials of experimental therapeutics in animal models, 3. Establishing a technology platform that would allow translation of imaging techniques evaluated in preclinical models to improve disease detection and monitoring of therapeutic response in the clinical arena. SABIR offers customized services to investigators relating to the use of state-of-the-art small animal imaging techniques including magnetic resonance imaging (MRI) and spectroscopy (MRS), fluorescent protein imaging and multispectral imaging. The Resource has recently expanded to include ultrasound (US), bioluminescence, photoacoustic, and x-ray imaging services. The Resource is led by two PhD faculty with extensive experience in small animal imaging, and is staffed by an additional 1.2 FTE resulting in a combined expenence of greater than 40 years in operating the resource. SABIR provides 24/7 access to and training in non-invasive imaging technologies to CCSG members in a cost-effective manner. First priority for use is given to peer-review-funded RPCI CCSG members; second priority to non-peerreview- funded CCSG members; third priority to non-members and academic collaborators; and last priority to external users. During the reporting period, the Small Animal Bio-Imaging Resource has served 29 members from 6 research programs, with 76% utilization by CCSG members with peer reviewed funding. CCSG support provides 12% of the overall proposed budget.