Small Animal BioImage

小动物生物图像

• 批准号: 8933329
• 负责人: DONALD L TRUMP
• 金额: $ 7.43万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-26 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8933329
• 关键词: Animal Disease Models; Animal Model; Animals; Biological Process; Bioluminescence; Budgets; Cancer Center Support Grant; Clinical; Data Set; Detection; Diagnostic; Disease; Disease Progression; Doctor of Philosophy; Faculty; Funding; Image; Image Analysis; Imaging Techniques; Imaging technology; Instruction; Magnetic Resonance Imaging; Malignant Neoplasms; Mission; Monitor; Patients; Peer Review; Pre-Clinical Model; Proteins; Reporting; Research; Research Personnel; Resources; Roswell Park Cancer Institute; Services; Spectrum Analysis; Techniques; Technology; Therapeutic; Training; Translating; Translations; Treatment outcome; Ultrasonography; bioimaging; cost effective; experience; image visualization; imaging modality; improved; in vivo imaging; insight; member; non-invasive imaging; novel; oncology; pre-clinical; preclinical study; programs; response

The overall mission of RPCI's Small Animal Bio-Imaging Resource (SABIR) is to provide specialized services relating to the imaging of small animal models of disease. The Resource provides scientific and technical services pertaining to image acquisition, quantitative image analysis, multidimensional renderings and visualization of imaging data sets for research. The objective of SABIR is to facilitate the conduct and progress of scientific research at RPCI by: 1. Providing the necessary intellectual and physical resources relating to non-invasive in vivo imaging, 2. Developing novel preclinical imaging techniques that provide insight into various biological processes involved in cancer and enable the conduct of preclinical trials of experimental therapeutics in animal models, 3. Establishing a technology platform that would allow translation of imaging techniques evaluated in preclinical models to improve disease detection and monitoring of therapeutic response in the clinical arena. SABIR offers customized services to investigators relating to the use of state-of-the-art small animal imaging techniques including magnetic resonance imaging (MRI) and spectroscopy (MRS), fluorescent protein imaging and multispectral imaging. The Resource has recently expanded to include ultrasound (US), bioluminescence, photoacoustic, and x-ray imaging services. The Resource is led by two PhD faculty with extensive experience in small animal imaging, and is staffed by an additional 1.2 FTE resulting in a combined expenence of greater than 40 years in operating the resource. SABIR provides 24/7 access to and training in non-invasive imaging technologies to CCSG members in a cost-effective manner. First priority for use is given to peer-review-funded RPCI CCSG members; second priority to non-peerreview- funded CCSG members; third priority to non-members and academic collaborators; and last priority to external users. During the reporting period, the Small Animal Bio-Imaging Resource has served 29 members from 6 research programs, with 76% utilization by CCSG members with peer reviewed funding. CCSG support provides 12% of the overall proposed budget.

RPCI 小动物生物成像资源 (SABIR) 的总体使命是提供专业的 与小动物疾病模型成像相关的服务。该资源提供科学和 与图像采集、定量图像分析、多维渲染相关的技术服务 以及用于研究的成像数据集的可视化。 SABIR 的目标是促进行为和 RPCI 的科学研究进展： 1. 提供与非侵入性活体成像相关的必要智力和物质资源， 2. 开发新颖的临床前成像技术，深入了解各种生物过程 参与癌症并能够在动物身上进行实验疗法的临床前试验 模型， 3. 建立一个技术平台，允许翻译评估的成像技术 临床前模型可改善疾病检测和临床治疗反应监测 竞技场。 SABIR 为研究人员提供与使用最先进的小动物成像相关的定制服务 技术包括磁共振成像 (MRI) 和光谱 (MRS)、荧光蛋白 成像和多光谱成像。该资源最近已扩展到包括超声波（美国）、 生物发光、光声和 X 射线成像服务。该资源由两名博士教师领导 在小动物成像方面拥有丰富的经验，并配备了额外的 1.2 FTE 人员，从而 运营该资源的总时间超过 40 年。 SABIR 提供 24/7 访问和 以具有成本效益的方式向 CCSG 成员提供非侵入性成像技术培训。 同行评审资助的 RPCI CCSG 成员优先使用；非同行评审的第二优先级 资助 CCSG 成员；第三优先权是非会员和学术合作者；和最后的优先级 给外部用户。报告期内，小动物生物成像资源已服务29个 来自 6 个研究项目的成员，其中 76% 的利用率由经过同行评审的 CCSG 成员使用。 CCSG 支持提供总体拟议预算的 12%。