Pathology

病理

• 批准号: 8933330
• 负责人: DONALD L TRUMP
• 金额: $ 7.16万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-26 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8933330
• 关键词: Archives; Area; Blood; Budgets; Cancer Center Support Grant; Clinical Research; Clinical Trials; Computer software; Core Facility; Disorder by Site; Doctor of Philosophy; Equipment; Faculty; Formalin; Freezing; Funding; Guidelines; Histology; Image; Image Analysis; Immunohistochemistry; Laboratories; Lasers; Leadership; Maintenance; Management Information Systems; Microdissection; Paraffin; Paraffin Embedding; Pathology; Peer Review; Process; Quality Control; Reporting; Research; Research Personnel; Research Subjects; Resource Sharing; Resources; Role; Roswell Park Cancer Institute; Scanning; Science; Services; Solutions; Spectral Karyotyping; System; Technology; The Cancer Genome Atlas; Time; Tissue Microarray; Tissue Procurements; Tissues; Translational Research; base; cost effective; cost effectiveness; cryostat; high standard; leukemia; macromolecule; member; programs; tissue resource

The RPCI Pathology Resource Network (PRN) Shared Resource, directed by Dr. Carl Morrison (GN), provides specialized technologies, services, and expertise involving all aspects of biospecimens through 6 integrated facilities: 1) Tissue Procurement, 2) Pathology Core Facility, 3) Paraffin Archive, 4) Special Functions Laboratory, 5) Correlative Science Pathology Office (CSPO), and 6) Leukemia Bank. This centralization of all aspects of biospecimen research provides stability, reliability, cost-effectiveness, and quality control. The PRN utilizes a state-of-the-art Laboratory Information Management System (LIMS) to effectively manage tissue resources, and maintains the highest standards of quality control. The 34 full time faculty and staff (7 staff supported by CCSG funding) in the PRN provide key services, including: tissue procurement (MD leadership and 5 staff); state-of-the-art research histology (PhD leadership and 5 staff); archive curation and maintenance of formalin fixed paraffin-embedded (FFPE) tissue (2 staff); special laboratory functions including image scanning and analysis (1 PhD leader); tissue microarray (TMA) (1 staff); laser microdissection (1 staff); macromolecule processing (1 staff); spectral karyotyping (1 PhD leader, 1 staff; biospecimen clinical trials support (RN leadership and 5 staff); leukemia banking (MD leadership, 3 staff). Some staff have roles in more than one area. The (CSPO) is new since the last CCSG submission and provides an effective solution to the need for biospecimens and correlative science in clinical research. The PRN provides tissue biospecimens to more than 25 clinical trials on an annual basis and blood to almost all interventional studies. The PRN provides centralized equipment, including: immunohistochemistry autostainers, frozen tissue cryostats, freezer alarms and management systems, Aperio image scanning ScanScope, image analysis software, Arcturus and Leica tissue microdissection platforms. All of these are managed by the sophisticated multi-million dollar LIMS. Access to tissues at RPCI is determined by the various Disease Site Research Groups (DSRGs), but the overall guidelines are set by the Tissue Utilization Committee (TUC), in accordance with CCSG guidelines. The PRN provides services to multiple peer-review funded investigators and provides major contributions to The Cancer Genome Atlas [PI: Dr. Carl Morrison (GN)]. First priority for use is given to peer-review-funded RPCI CCSG members; second priority to non-peer-review- funded CCSG members; third priority to non-members and academic collaborators; and last priority to external users. During the reporting period, the PRN shared resource has served 85 members from 6 research programs, with 48% utilization by CCSG members with peer reviewed funding. The CCSG makes up 9% of the overall proposed budget.

RPCI 病理学资源网络 (PRN) 共享资源，由 Carl Morrison 博士 (GN) 指导， 通过 6 个综合设施提供涉及生物样本各个方面的专业技术、服务和专业知识：1) 组织采购，2) 病理学核心设施，3) 石蜡档案，4) 特殊设施 功能实验室，5) 相关科学病理学办公室 (CSPO)，以及 6) 白血病库。这 生物样本研究各个方面的集中提供了稳定性、可靠性、成本效益和 质量控制。 PRN 利用最先进的实验室信息管理系统 (LIMS) 有效管理组织资源，并保持最高的质量控制标准。 34 全职 PRN 的教职员工（7 名员工由 CCSG 资助）提供关键服务，包括： 采购（总经理领导层和 5 名员工）；最先进的组织学研究（博士领导和 5 名工作人员）； 福尔马林固定石蜡包埋 (FFPE) 组织的档案管理和维护（2 名工作人员）；特别的 实验室功能包括图像扫描和分析（1名博士带头人）；组织微阵列 (TMA) (1 职员）;激光显微切割（1 名工作人员）；高分子加工（1人）；光谱核型分析（1 名博士 领导、工作人员1名；生物样本临床试验支持（RN 领导和 5 名工作人员）；白血病银行（MD 领导，3名工作人员）。有些员工在多个领域担任职务。 (CSPO) 自上次 CCSG 提交以来是新的，为满足以下需求提供了有效的解决方案： 临床研究中的生物样本和相关科学。 PRN 为更多人提供组织生物样本 每年进行超过 25 项临床试验，并为几乎所有介入研究提供血液。 PRN 提供 集中设备，包括：免疫组织化学自动染色机、冷冻组织低温恒温器、冷冻警报器 和管理系统、Aperio 图像扫描 ScanScope、图像分析软件、Arcturus 和 Leica 组织显微切割平台。所有这些均由耗资数百万美元的先进 LIMS 管理。 RPCI 组织的获取由各个疾病现场研究小组 (DSRG) 决定，但 总体指南由组织利用委员会 (TUC) 根据 CCSG 指南制定。 PRN 为多个同行评审资助的研究人员提供服务，并为以下领域做出了重大贡献： 癌症基因组图谱 [PI：Carl Morrison 博士 (GN)]。 同行评审资助的 RPCI CCSG 成员优先使用；非同行评审的第二优先级 资助 CCSG 成员；第三优先权是非会员和学术合作者；和最后优先级 外部用户。报告期内，PRN共享资源已服务6个国家85个会员 研究项目，CCSG 成员利用同行评审资金的比例为 48%。 CCSG 使 占拟议预算总额的 9%。