Translational Cancer Biology Training Grant

项目摘要 这个修订后的，有竞争力的续约申请寻求一个年轻的，但非常成功的继续支持 马萨诸塞州大学医学院（UMMS）的转化癌症生物学培训项目 每年资助四名博士后和两名博士前实习生，他们致力于癌症事业 research.该计划吸引了有才华和积极主动的学员谁利用一流的培训 环境，以促进他们在癌症研究的职业生涯。我们的博士前实习生已发表在顶级 期刊，并在领先机构获得癌症研究的博士后和教职，以及 博士后学员在学术界和生物技术界找到了工作。 该计划拥有强大的机构支持，位于UMMS癌症生物学系 但它包括大多数基础科学和临床部门的教师。事实上，我们的一个主要优势是 该计划是将UMMS的癌症相关活动整合到一个高度可见的统一计划中 作为一种有效的培训机制。在获得这笔补助金之前，他们从未接受过正式的培训 癌症生物学的研究项目T32统一和加强了癌症培训和研究， 我们的机构更具体地说，我们已经实现并打算维持和加强 这一培训计划的目的是：为癌症研究提供一个正式的培训机制; 增加高素质的申请人，包括来自不同背景的人，我们的前和后， 博士课程;促进跨部门的癌症研究;桥梁基础和临床癌症研究;以及 提高癌症研究在UMMS的知名度和声望。 该计划的目标是通过以下方式为学员提供对癌症作为一种疾病的理解和欣赏 让他们接触到临床癌症研究和医学。这一目标是通过课程来实现的， 提供的活动，并通过与卓越的UMASS癌症中心和中心的互动， 临床和转化科学。受训者通过参加基于疾病的临床 癌症中心的会议（如下所述），并与特定的临床医生合作，以促进 他们的研究，并加强其临床相关性和影响。这种方法非常有效， 成功 参加该计划的三十名教师是根据他们的科学成就挑选出来的 癌症研究的资助记录，在当前资助期间的表现，以及 在指导学员方面的热情和经验。癌症遗传学和细胞生物学的基本机制， 转化癌症研究是该计划教师的主要研究兴趣。我们的计划培养 基础科学家和转化科学家之间的互动和合作，包括受训者的参与。

Project Summary This revised, competitive renewal application seeks continued support of a young, but highly successful training program in Translational Cancer Biology at the University of Massachusetts Medical School (UMMS) that funds four post-doctoral and two pre-doctoral trainees per year who are committed to careers in cancer research. The program attracts talented and motivated trainees who take advantage of the superb training environment to foster their careers in cancer research. Our pre-doctoral trainees have published in top-tier journals and obtained postdoctoral and faculty positions in cancer research at leading institutions, and postdoctoral trainees have secured jobs in academia and bio-tech. The program, which has strong institutional support, is based in the Department of Cancer Biology at UMMS but it includes faculty from most basic science and clinical departments. Indeed, a major strength of our program is that is integrates the cancer-related activities at UMMS into a unified program that is highly visible and effective as a training mechanism. Until the award of this grant, their had never been a formal training program in cancer biology at UMMS. This T32 has unified and strengthened cancer training and research at our institution. More specifically, we have achieved and intend to maintain and strengthen the original goals of this training program, which were to: provide a formal mechanism for outstanding training in cancer research; Increase the pool of highly qualified applicants including those from diverse backgrounds to our pre- and post- doctoral programs; facilitate inter-departmental cancer research; bridge basic and clinical cancer research; and enhance the visibility and prestige of cancer research at UMMS. A goal of this program is to provide trainees with an understanding and appreciation for cancer as a disease by exposing them to clinical cancer research and medicine. This goal is accomplished by the courses and activities offered, and through interactions with the UMASS Cancer Center of Excellence and the Center for Clinical and Translational Science. Trainees interact with clinicians by participating in disease-based clinical conferences of the Cancer Center (described below) and by collaborating with specific clinicians to facilitate their research and strengthen its clinical relevance and impact. This approach has been very effective and successful. The thirty faculty members participating in this program were selected based on their scientific achievements and track record of funding in cancer research, performance during the current funding period, and their passion and experience in mentoring trainees. Basic mechanisms of cancer genetics and cell biology, and translational cancer research are the major research interests of the program faculty. Our program fosters interactions and collaborations between basic and translational scientists that involve trainee participation.