Neural Substrates of Affective Style and Emotion Regulation

描述（由申请人提供）：这是R01-MH43454竞争延续的修订。这项申请寻求额外五年的支持，以继续PI关于情感风格和情绪调节的神经基础的研究项目。情感风格和情绪调节的个体差异决定了应激反应的变化以及对情绪、焦虑和外化障碍的脆弱性。这项应用的主要目标是进一步了解情绪调节个体差异背后的神经回路，并确定消极和积极情绪的自愿和自动调节形式的神经基础和生物行为相关之间的关系。我们还建议将这项工作扩展到青少年晚期他们是纵向样本的一部分我们在过去的5年里一直在用成像和行为测量来跟踪他们从出生开始我们就有了他们的行为和激素数据。一项主要研究将检查消极和积极情绪的自愿和自动调节之间的关系，以确定一种技能是否能预测另一种技能，并确定两者之间是否存在重叠或正交的神经基质，包括激活和连接测量。我们将特别讨论一个问题，即那些擅长下调消极情绪的参与者是否也擅长上调积极情绪。作为本研究的一部分，我们还将探讨图片诱发的负性情绪调节与热痛诱发的负性情绪调节之间的关系。另一项研究将考察工作记忆（WM）容量的个体差异与情绪调节之间的关系。除了评估情绪调节的任务外，参与者还将在扫描仪上进行工作记忆任务（n-back），并确定在WM和情绪调节任务期间前额叶皮层重叠的激活区域。此外，我们将研究工作记忆容量与自动和自愿情绪调节之间的关系。最后，使用来自威斯康星家庭和工作研究的样本，我们将检查情绪调节的个体差异与精神病理学症状和诊断之间的关系。我们还将把情绪调节的神经和心理生理测量与已经收集到的这些参与者的纵向数据语料库联系起来。这项工作将为情感风格的神经生物学提供重要的新信息。这些新数据将进一步加深我们对与精神病理易感性相关的情感处理的内表型的理解。

DESCRIPTION (provided by applicant): This is a revision of the competing continuation of R01-MH43454. This application seeks five additional years of support to continue the PI's research program on the neural substrates of affective style and emotion regulation. Individual differences in affective style and emotion regulation determine variation in stress responsivity and vulnerability to mood, anxiety and externalizing disorders. The broad goal of this application is to further understand the neural circuitry underlying individual differences in emotion regulation and to determine the relation between the neural bases and biobehavioral correlates of voluntary and automatic forms of the regulation of negative and positive affect. Work is proposed that also extends this work to late adolescents who are part of a longitudinal sample that we have been following with imaging and behavioral measures for the past 5 years and on whom we have behavioral and hormonal data since birth. One major study will examine relations between voluntary and automatic regulation of both negative and positive emotion to determine if skill in one predicts skill in the others, and to determine if there is overlapping or orthogonal neural substrates of each, including activation and connectivity measures. We will specifically address the question of whether participants who are skilled at down-regulating negative affect are also skilled at upregulating positive affect. As part of this study, we will also examine relations between the regulation of picture-induced negative affect and thermal pain-induced negative affect. Another study will examine relations between individual differences in working memory (WM) capacity and emotion regulation. In addition to tasks assessing emotion regulation, participants will be given a working memory task (n-back) in the scanner and activated regions of overlap in the prefrontal cortex during the WM and emotion regulation tasks will be determined. In addition, we will examine relations between working memory capacity and automatic and voluntary emotion regulation. Finally, using a sample derived from the Wisconsin Study of Families and Work, we will examine relations between individual differences in emotion regulation and symptoms and diagnoses of psychopathology. We will also relate neural and psychophysiological measures of emotion regulation to the longitudinal corpus of data already collected on these participants. This work will provide critical new information on the neurobiology of affective style. These new data will further our understanding of endophenotypes of affective processing that are associated with vulnerability to psychopathology.