2014 Thiol-based Redox Regulation & Signaling GRC and GRS

2014年硫醇氧化还原法规

• 批准号: 8718428
• 负责人: Cristina Maria Furdui
• 金额: $ 2.7万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-03-15 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8718428
• 关键词: Academia; Advanced Development; Aging; Aging-Related Process; Animal Model; Antioxidants; Area; Attention; Award; Basic Science; Bioinformatics; Biological; Biological Models; Biology; Biology of Aging; Calculi; Cardiovascular Diseases; Cardiovascular system; Career Choice; Cell model; Cell physiology; Cells; Chemicals; Chemistry; Clinical; Clinical Research; Collaborations; Cysteine; DNA biosynthesis; Detection; Development; Disease; Epigenetic Process; Equilibrium; Europe; European; Financial Support; Fostering; France; Functional disorder; Funding; Gene Expression; Golf; Government; Homeostasis; Human; Industry; Inflammation; Inflammatory; Institution; International; Investigation; Italy; Knowledge; Lead; Life; Link; Location; Maine; Malignant Neoplasms; Melia; Metabolism; Methionine; Methodology; Mission; Mitochondria; Modification; Molecular; Molecular Medicine; National Institute of General Medical Sciences; Nature; Neurodegenerative Disorders; Nitrogen; Outcome; Oxidases; Oxidation-Reduction; Oxidative Stress; Oxidoreductase; Oxygen; Pathologic Processes; Pathology; Physicians; Physiological; Physiology; Preparation; Process; Proteins; Reagent; Regulation; Request for Proposals; Research; Research Personnel; Science; Scientist; Series; Side; Signal Transduction; Site; South Carolina; Spain; Sulfhydryl Compounds; Sulfur; System; Technology; Time; Translating; Translational Research; United States National Institutes of Health; Universities; Work; age related; base; biological systems; biophysical techniques; college; combat; disulfide bond; graduate student; insight; interest; meetings; member; normal aging; novel; novel strategies; novel therapeutics; oxidation; oxidative damage; programs; protein aggregation; protein function; public health relevance; success; symposium; therapy development

DESCRIPTION (provided by applicant): This proposal requests support for the Fifth Gordon Research Conference, and second associated Gordon Research Seminar on Thiol-Based Redox Regulation and Signaling to be held at the Melia Golf Vichy Catalan, Girona, Spain on July 19-20 (GRS) / 20-25 (GRC) 2014. The subtitle of this conference, "From Redox Biology and Chemistry to Aging and Associated Diseases," reflects the focus of the upcoming meeting on the fundamental cellular processes that are governed by redox-based modifications of protein function, and on the dysregulation of these processes that occur during aging and its associated pathologies. Redox biology is an all-encompassing term that refers to the multitude of reduction and oxidation processes occurring in biological molecules. This Gordon conference focuses specifically on the redox regulation of protein function by modification of cysteine and methionine residues and on the agents that modulate the redox state of these residues. These include both cellular protein reductase and oxidase systems, and endogenous and exogenous reactive oxygen and nitrogen species - ROS and RNS, respectively that are sulfur-reactive. Thiol-based redox processes underlie many cellular processes that are altered during aging and associated diseases. These include protein oxidative folding and secretion, mitochondrial functions, oxygen, ROS and RNS sensing and signaling, ROS and RNS metabolism, DNA synthesis and gene expression. Given that aging and associated diseases are suspected to result from progressive breakdown of redox homeostasis, a better description of the redox components in cellular processes will help establish whether and how biological systems are susceptible to physiological alterations and disease development. This interdisciplinary conference is in its fifth cycle after four very successful meetings in the U.S. (2006 and 2012) and Italy (2008 and 2010). It will provide, as it has in the past, an important venue for the free exchange of ideas and methodologies among the chemists, biochemists, molecular and cell biologists, physiologists, and clinicians working on various aspects of the field. While the thematic area of the conference is broad-based, its relevance to aging and associated diseases (e.g., inflammation, protein aggregation diseases) and for understanding the molecular basis of human physiology and pathology is highly significant. By bringing together investigators with varied expertise in biophysical methods, bioinformatics and animal and cellular model systems, with clinical researchers and physicians focused on disease processes, the meeting is expected to further stimulate collaborations and catalyze scientific progress as has been exemplified by the successes of the previous meetings. For the second time, the GRC will be preceded by a Gordon Research Seminar (GRS) (July 19-20, 2014), which will provide an opportunity for graduate students and postdoctoral scientists to formally present research and engage in scientific discussions. We expect this to continue to attract and increase retention of young scientists to the field of redox biology and aging.

描述（由申请人提供）：本提案要求支持第五届戈登研究会议，以及将于2014年7月19日至20日（GRS）/ 20日至25日（GRC）在西班牙赫罗纳的Melia Golf Vichy Catalan举行的第二届相关的基于硫醇的氧化还原调节和信号传导戈登研究研讨会。本次会议的副标题，“从氧化还原生物学和化学到衰老和相关疾病”，反映了即将举行的会议的重点是由蛋白质功能的氧化还原修饰所控制的基本细胞过程，以及在衰老及其相关病理过程中发生的这些过程的失调。氧化还原生物学是一个包罗万象的术语，指的是生物分子中发生的大量还原和氧化过程。这次戈登会议特别关注通过半胱氨酸和蛋氨酸残基的修饰对蛋白质功能的氧化还原调节，以及调节这些残基氧化还原状态的试剂。这些包括细胞蛋白质还原酶和氧化酶系统，以及分别是硫反应性的内源性和外源性活性氧和氮物质- ROS和RNS。基于巯基的氧化还原过程是许多细胞过程的基础，这些过程在衰老和相关疾病期间发生改变。这些包括蛋白质氧化折叠和分泌，线粒体功能，氧，ROS和RNS传感和信号传导，ROS和RNS代谢，DNA合成和基因表达。考虑到衰老和相关疾病被怀疑是由氧化还原稳态的进行性破坏引起的，更好地描述细胞过程中的氧化还原组分将有助于确定生物系统是否以及如何容易受到生理变化和疾病发展的影响。这个跨学科的会议是在美国（2006年和2012年）和意大利（2008年和2010年）四次非常成功的会议后的第五个周期。它将提供，因为它在过去，为化学家，生物化学家，分子和细胞生物学家，生理学家和临床医生之间的思想和方法的自由交流的重要场所工作在该领域的各个方面。虽然会议的主题领域基础广泛，但其与老龄化和相关疾病的相关性（例如，炎症、蛋白质聚集性疾病）的研究以及对于理解人类生理学和病理学的分子基础具有高度意义。通过将在生物物理方法、生物信息学以及动物和细胞模型系统方面具有不同专业知识的研究人员与专注于疾病过程的临床研究人员和医生聚集在一起，预计会议将进一步促进合作，并推动科学进步，这一点已在以前的会议上取得成功。第二次，GRC将由戈登研究研讨会（GRS）（2014年7月19日至20日）之前，这将为研究生和博士后科学家提供一个机会，正式提出研究和从事科学讨论。我们希望这将继续吸引和增加年轻科学家对氧化还原生物学和衰老领域的保留。