Redox Biology and Medicine Training Program

这项提案寻求为NRSA机构博士前培训补助金从系统和 国家普通医学研究所综合生物学项目。这笔赠款将支持 氧化还原生物学和医学(RBM)博士前培训导致维克森林大学获得博士学位 大学。成果管理制培训计划是一个多学科、多部门的计划，其目标是 对从事生物医学、生物、化学和物理等学科的研究人员的培训 跨学科交流和合作，深入研究氧化和还原的专业化学 它指导信号转导通路并调节疾病。成果管理制培训的24名成员 教职员工高度合作，包括生物化学、分子医学、癌症生物学、 生物医学工程、化学、生物学和物理学。成果管理制培训的主要科学主题 该计划包括(I)氧化修饰调节信号转导通路的重叠区域， (Ii)核酸代谢和细胞周期的氧化还原调节；(Iii)活性氮物种生物化学和 与人类健康有关的生物物理学，以及(Iv)与氧化还原有关的疾病发生、进展和发展机制 治疗。成果管理制培训计划有一个灵活的课程，围绕课程的共同核心在 氧化还原生物学和医学的基础知识和特定于技术的迷你课程，以及该学科- 符合受训人员博士项目要求的具体课程。参加该计划的学生是 在化学生物学、蛋白质组学和代谢组学、酶学、动物模型等领域接受过培训 疾病、线粒体生物学和网络建模。培训计划充分利用了这些活动 由分子信号中心与氧化还原生物和医学中心协同发起， 包括一个完善的跨学科研讨会和务虚会制度，以促进 该计划的成员。学生还参加以实习生为重点的粉笔讲座，以促进 跨学科的沟通能力对这一领域的多学科研究至关重要。我们还提供 为我们的博士毕业生提供各种潜在职业技能的具体培训，包括学术培训 职业，生物技术和制药行业的职业，以及知识分子的职业 地产竞技场。我们已经开发了一条管道，让生物医学科学的硕士研究生， 在我们的项目中，化学、物理、数学和计算机科学可以过渡到博士培训。 在20-30名学生的稳定水平中，需要为4个博士前职位申请资金 培训学院的实验室。这些职位将用于支持二年级或以下的学生 之后，很明显，他们的论文研究与 程序。支持期限最长为两年，之后学生将由 由他们的顾问或他们自己的个人奖学金提供的研究经费。

This proposal seeks funding for an NRSA Institutional Predoctoral Training Grant from the Systems and Integrative Biology Program of the National Institute for General Medical Sciences. This grant will support predoctoral training in Redox Biology and Medicine (RBM) leading to a Ph.D. degree at Wake Forest University. The RBM Training Program is a multi-disciplinary, multi-departmental program that has as its goal the training of researchers working at the interface of biomedical sciences, biology, chemistry and physics to communicate and work across disciplines to delve into the specialized chemistry of oxidation and reduction which directs signal transduction pathways and modulates disease. The 24 members of the RBM training faculty are highly collaborative, and include faculty from Biochemistry, Molecular Medicine, Cancer Biology, Biomedical Engineering, Chemistry, Biology, and Physics. Major scientific themes of the RBM Training Program include the overlapping areas of (i) oxidative modifications regulating signal transduction pathways, (ii) redox regulation of nucleic acid metabolism and cell cycle, (iii) reactive nitrogen species biochemistry and biophysics relating to human health, and (iv) redox-linked mechanisms of disease initiation, progression and treatment. The RBM training program has a flexible curriculum built around a common core of a course in Fundamentals in Redox Biology and Medicine and technology-specific minicourses, as well as the discipline- specific courses to meet the requirements of the Ph.D. programs of the trainees. Students in the program are trained in such areas as chemical biology, proteomics and metabolomics, enzymology, animal models of disease, mitochondrial biology and network modeling. The training program takes advantage of the activities initiated by the Center for Molecular Signaling synergistically with the Center for Redox Biology and Medicine, including a well-developed system of interdisciplinary seminars and retreats to promote interaction among members of the program. Students also participate in trainee-focused chalk talks which foster development in the cross-discipline communication skills so critical to the multi-disciplinary research in this field. We also offer specific training in skills for a wide variety of potential careers for our Ph.D. graduates, including academic careers, careers in the biotechnology and pharmaceutical industries, as well as careers in the intellectual property arena. We have developed a pipeline in which Master's degree students in Biomedical Science, Chemistry, Physics, Mathematics and Computer Science can transition into Ph.D. training in our program. Funding is requested for 4 predoctoral positions out of the steady state level of 20-30 students in the laboratories of the training faculty. These positions will be used to support students in the second year or beyond, at which time it will be apparent that their dissertation research is consistent with the goals of the Program. Support will be for a maximum of two years, after which the students will be supported by the research funding of their advisors or their own individual fellowships.