Redox Biology and Medicine Training Program

该提案旨在为NRSA机构的博士前培训补助金提供资金， 国立普通医学科学研究所综合生物学计划。这笔资金将支持 在氧化还原生物学和医学（RBM）的博士前培训，导致博士学位。维克森林的温度 大学RBM培训计划是一个多学科，多部门的计划，其目标是 培训在生物医学、生物学、化学和物理学领域工作的研究人员， 跨学科交流和工作，深入研究氧化和还原的专业化学 其指导信号传导途径并调节疾病。成果管理制培训的24名成员 教师高度合作，包括生物化学，分子医学，癌症生物学， 生物医学工程、化学、生物学和物理学。成果管理制培训的主要科学主题 计划包括重叠领域（i）氧化修饰调节信号转导途径， (ii)核酸代谢和细胞周期的氧化还原调节，（iii）活性氮类生物化学和 与人类健康有关的生物物理学，以及（iv）与疾病发生、进展和 治疗成果管理制培训方案有一个灵活的课程，围绕一个共同的核心课程， 氧化还原生物学和医学的基础知识和技术特定的微型课程，以及学科- 具体课程，以满足博士学位的要求。学员的方案。该计划的学生是 在化学生物学、蛋白质组学和代谢组学、酶学、 疾病，线粒体生物学和网络建模。培训计划利用了这些活动 由分子信号中心与氧化还原生物学和医学中心协同发起， 包括完善的跨学科研讨会和务虚会系统，以促进 节目的成员。学生们还参加以受训者为中心的粉笔会谈， 跨学科的沟通能力对该领域的多学科研究至关重要。我们还提供 在技能的各种各样的潜在职业为我们的博士的具体培训。毕业生，包括学术 职业生涯，在生物技术和制药行业的职业生涯，以及在知识分子的职业生涯， 地产竞技场。我们已经开发了一个管道，其中硕士学位的学生在生物医学科学， 化学，物理，数学和计算机科学可以过渡到博士学位。在我们的培训计划中。 资助要求4个博士前职位的稳定状态水平的20-30名学生在 培训学院的实验室。这些职位将用于支持学生在第二年或 除此之外，在那个时候，很明显，他们的论文研究是符合目标的。 程序.支持最长为两年，之后学生将得到 他们的顾问或他们自己的个人奖学金的研究资金。

This proposal seeks funding for an NRSA Institutional Predoctoral Training Grant from the Systems and Integrative Biology Program of the National Institute for General Medical Sciences. This grant will support predoctoral training in Redox Biology and Medicine (RBM) leading to a Ph.D. degree at Wake Forest University. The RBM Training Program is a multi-disciplinary, multi-departmental program that has as its goal the training of researchers working at the interface of biomedical sciences, biology, chemistry and physics to communicate and work across disciplines to delve into the specialized chemistry of oxidation and reduction which directs signal transduction pathways and modulates disease. The 24 members of the RBM training faculty are highly collaborative, and include faculty from Biochemistry, Molecular Medicine, Cancer Biology, Biomedical Engineering, Chemistry, Biology, and Physics. Major scientific themes of the RBM Training Program include the overlapping areas of (i) oxidative modifications regulating signal transduction pathways, (ii) redox regulation of nucleic acid metabolism and cell cycle, (iii) reactive nitrogen species biochemistry and biophysics relating to human health, and (iv) redox-linked mechanisms of disease initiation, progression and treatment. The RBM training program has a flexible curriculum built around a common core of a course in Fundamentals in Redox Biology and Medicine and technology-specific minicourses, as well as the discipline- specific courses to meet the requirements of the Ph.D. programs of the trainees. Students in the program are trained in such areas as chemical biology, proteomics and metabolomics, enzymology, animal models of disease, mitochondrial biology and network modeling. The training program takes advantage of the activities initiated by the Center for Molecular Signaling synergistically with the Center for Redox Biology and Medicine, including a well-developed system of interdisciplinary seminars and retreats to promote interaction among members of the program. Students also participate in trainee-focused chalk talks which foster development in the cross-discipline communication skills so critical to the multi-disciplinary research in this field. We also offer specific training in skills for a wide variety of potential careers for our Ph.D. graduates, including academic careers, careers in the biotechnology and pharmaceutical industries, as well as careers in the intellectual property arena. We have developed a pipeline in which Master's degree students in Biomedical Science, Chemistry, Physics, Mathematics and Computer Science can transition into Ph.D. training in our program. Funding is requested for 4 predoctoral positions out of the steady state level of 20-30 students in the laboratories of the training faculty. These positions will be used to support students in the second year or beyond, at which time it will be apparent that their dissertation research is consistent with the goals of the Program. Support will be for a maximum of two years, after which the students will be supported by the research funding of their advisors or their own individual fellowships.