Redox Biology and Medicine Training Program

氧化还原生物学与医学培训计划

• 批准号: 10200839
• 负责人: Cristina Maria Furdui
• 金额: $ 19.51万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10200839
• 关键词: Biology; Medicine; Oxidation-Reduction; Training Programs

This proposal seeks funding for an NRSA Institutional Predoctoral Training Grant from the Systems and Integrative Biology Program of the National Institute for General Medical Sciences. This grant will support predoctoral training in Redox Biology and Medicine (RBM) leading to a Ph.D. degree at Wake Forest University. The RBM Training Program is a multi-disciplinary, multi-departmental program that has as its goal the training of researchers working at the interface of biomedical sciences, biology, chemistry and physics to communicate and work across disciplines to delve into the specialized chemistry of oxidation and reduction which directs signal transduction pathways and modulates disease. The 24 members of the RBM training faculty are highly collaborative, and include faculty from Biochemistry, Molecular Medicine, Cancer Biology, Biomedical Engineering, Chemistry, Biology, and Physics. Major scientific themes of the RBM Training Program include the overlapping areas of (i) oxidative modifications regulating signal transduction pathways, (ii) redox regulation of nucleic acid metabolism and cell cycle, (iii) reactive nitrogen species biochemistry and biophysics relating to human health, and (iv) redox-linked mechanisms of disease initiation, progression and treatment. The RBM training program has a flexible curriculum built around a common core of a course in Fundamentals in Redox Biology and Medicine and technology-specific minicourses, as well as the discipline- specific courses to meet the requirements of the Ph.D. programs of the trainees. Students in the program are trained in such areas as chemical biology, proteomics and metabolomics, enzymology, animal models of disease, mitochondrial biology and network modeling. The training program takes advantage of the activities initiated by the Center for Molecular Signaling synergistically with the Center for Redox Biology and Medicine, including a well-developed system of interdisciplinary seminars and retreats to promote interaction among members of the program. Students also participate in trainee-focused chalk talks which foster development in the cross-discipline communication skills so critical to the multi-disciplinary research in this field. We also offer specific training in skills for a wide variety of potential careers for our Ph.D. graduates, including academic careers, careers in the biotechnology and pharmaceutical industries, as well as careers in the intellectual property arena. We have developed a pipeline in which Master's degree students in Biomedical Science, Chemistry, Physics, Mathematics and Computer Science can transition into Ph.D. training in our program. Funding is requested for 4 predoctoral positions out of the steady state level of 20-30 students in the laboratories of the training faculty. These positions will be used to support students in the second year or beyond, at which time it will be apparent that their dissertation research is consistent with the goals of the Program. Support will be for a maximum of two years, after which the students will be supported by the research funding of their advisors or their own individual fellowships.

该提案为系统和 国家一般医学科学研究所的综合生物学计划。这笔赠款将支持 氧化还原生物学和医学（RBM）培训的培训，导致博士学位。威克森林学位 大学。 RBM培训计划是一个多学科的多部门计划，其目标是 在生物医学，生物学，化学和物理学界面上工作的研究人员的培训 跨学科进行交流和工作，以深入研究氧化和减少的专业化学 指导信号转导途径并调节疾病。 RBM培训的24名成员 教师是高度协作的，包括生物化学，分子医学，癌症生物学， 生物医学工程，化学，生物学和物理学。 RBM培训的主要科学主题 程序包括（i）调节信号转导途径的（i）氧化修饰的重叠区域， （ii）核酸代谢和细胞周期的氧化还原调节，（iii）反应性氮物种生物化学和 与人类健康有关的生物物理学以及（iv）疾病起步，进展和 治疗。 RBM培训计划具有灵活的课程，围绕着课程的共同核心 氧化还原生物学和医学和技术特异性小型的基础知识以及学科 特定课程满足博士学位的要求。学员的计划。该计划中的学生是 在化学生物学，蛋白质组学和代谢组学，酶学，动物模型等领域接受培训 疾病，线粒体生物学和网络建模。培训计划利用活动 由分子信号中心与氧化还原生物学和医学中心协同发起 包括跨学科研讨会和务虚会的完善系统，以促进互动 该计划的成员。学生还参加以学员为中心的粉笔谈话，以促进 跨学科的沟通技巧对于该领域的多学科研究至关重要。我们也提供 针对我们博士学位的各种潜在职业的技能培训。毕业生，包括学术 职业，生物技术和制药行业的职业以及知识分子的职业 物业竞技场。我们已经开发了一条管道，在该管道中，硕士学位学生在生物医学科学领域， 化学，物理，数学和计算机科学可以过渡到博士学位。我们计划的培训。 资金要求从20-30名学生的稳态级别列出4个占主导地位的职位。 培训教师的实验室。这些职位将在第二年用于支持学生或 除此之外，在那个时候，显然他们的论文研究与目标一致 程序。支持最多将是两年，然后学生将得到学生的支持 研究其顾问或自己的个人奖学金的资金。