Cancer Research International Training and Intervention Consortium (CRITIC)

描述(由申请人提供)：拟议的癌症联盟专注于干预两种最常见的艾滋病相关癌症--坦桑尼亚的卡波西肉瘤相关人类疱疹病毒(KSHV)和人乳头瘤病毒(HPV)--的传播和感染。该联盟的目标是加强艾滋病恶性疾病研究基础设施的三个关键组成部分--病毒学、流行病学和临床护理--将在这些领域拥有有据可查的优势的合作伙伴联系起来。除了获得与艾滋病相关的恶性肿瘤的关键数据外，该联盟还将提供多样化的培训机会，以增加当地的专业知识和转让技术。总体而言，这一伙伴关系最终将导致建立技术和人员基础设施的交流 开展坦桑尼亚迫切需要的高质量生物医学、行为和预防性生物医学研究。将实现四个具体目标：1)通过长期的分子癌症流行病学培训机会，建设该联盟的研究能力，长期培训导致获得流行病学和分子肿瘤病毒学的两个博士学位，分子肿瘤病毒学的硕士学位，以及癌症流行病学的公共卫生硕士学位。2)通过在美国的短期技术培训和针对研究人员、临床医生和公共卫生人员的国内研讨会，加强现有的癌症研究能力。3)发展分子病毒学研究实验室组成部分和流行病学/生物统计学核心设施，以支持分子癌症流行病学研究项目。4)支持坦桑尼亚研究团队的发展，并通过支持两个假设驱动的研究项目来提高研究生产率，这两个研究项目涉及两种最常见的艾滋病相关恶性肿瘤--KS和宫颈癌。这项拟议的计划是独一无二的，影响很大，因为它建立在撒哈拉以南非洲正在进行的成功的Fogarty计划和NCI培训计划的基础上，将其扩展为一个真正的跨学科研究和培训计划，具有不同的培训路线，并与坦桑尼亚和美国的研究项目合作，对KS、宫颈癌及其各自的病因进行假设驱动的研究。

DESCRIPTION (provided by applicant): The proposed Cancer Consortium focuses on the intervention of transmission and infection by two etiologic viral agents of the two most common AIDS-associated cancers, the Kaposi's sarcoma-associated human herpes virus (KSHV) and Human Papilloma Virus (HPV) in Tanzania. The objective of the Consortium is to enhance the three critical components of AIDS malignancies research infrastructure - virology, epidemiology and clinical care - by linking partners with documented strengths in these areas. In addition to deriving critical data on AIDS-associated malignancies, the Consortium will provide diverse training opportunities to increase local expertise and transfer technology. Overall, the partnership will ultimately lead to exchanges that build the technical and personnel infrastructure necessary to perform the high-quality biomedical, behavioral, and preventative biomedical research desperately needed in Tanzania. Four specific aims will be pursued: 1) Build the consortium's research capacity through long-term molecular cancer epidemiology training opportunities, with long-term training leading to two PhDs, in epidemiology and in molecular tumor virology, MS degrees in molecular tumor virology, and MPH degrees in cancer epidemiology. 2) Strengthen existing cancer research capacity through short term technical training in the US and in-country workshops targeting researchers, clinicians, and public health personnel. 3) Develop a molecular virology research laboratory component and epidemiology/biostatistics core facilities to support molecular cancer epidemiology research projects. 4) Support the development of Tanzanian research teams and increase the research productivity through supporting two hypothesis-driven research projects in the two most prevalent AIDS-associated malignancies, KS and cervical cancer. This proposed program is unique and of high impact because it builds onto a successful ongoing Fogarty program and NCI training program in sub-Saharan Africa, expanding it into a truly cross-disciplinary research and training program with different training tracks and with in-country research projects teaming Tanzanian and U.S. researchers to conduct hypothesis-driven research on KS, cervical cancer, and their respective etiologic agents.