Cancer Research International Training and Intervention Consortium (CRITIC)

癌症研究国际培训和干预联盟 (CRITIC)

• 批准号: 8928588
• 负责人: Amr Soliman
• 金额: $ 74.9万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-17 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8928588
• 关键词: Cancer; Research; International; Training; Intervention

DESCRIPTION (provided by applicant): The proposed Cancer Consortium focuses on the intervention of transmission and infection by two etiologic viral agents of the two most common AIDS-associated cancers, the Kaposi's sarcoma-associated human herpes virus (KSHV) and Human Papilloma Virus (HPV) in Tanzania. The objective of the Consortium is to enhance the three critical components of AIDS malignancies research infrastructure - virology, epidemiology and clinical care - by linking partners with documented strengths in these areas. In addition to deriving critical data on AIDS-associated malignancies, the Consortium will provide diverse training opportunities to increase local expertise and transfer technology. Overall, the partnership will ultimately lead to exchanges that build the technical and personnel infrastructure necessary to perform the high-quality biomedical, behavioral, and preventative biomedical research desperately needed in Tanzania. Four specific aims will be pursued: 1) Build the consortium's research capacity through long-term molecular cancer epidemiology training opportunities, with long-term training leading to two PhDs, in epidemiology and in molecular tumor virology, MS degrees in molecular tumor virology, and MPH degrees in cancer epidemiology. 2) Strengthen existing cancer research capacity through short term technical training in the US and in-country workshops targeting researchers, clinicians, and public health personnel. 3) Develop a molecular virology research laboratory component and epidemiology/biostatistics core facilities to support molecular cancer epidemiology research projects. 4) Support the development of Tanzanian research teams and increase the research productivity through supporting two hypothesis-driven research projects in the two most prevalent AIDS-associated malignancies, KS and cervical cancer. This proposed program is unique and of high impact because it builds onto a successful ongoing Fogarty program and NCI training program in sub-Saharan Africa, expanding it into a truly cross-disciplinary research and training program with different training tracks and with in-country research projects teaming Tanzanian and U.S. researchers to conduct hypothesis-driven research on KS, cervical cancer, and their respective etiologic agents.

描述（由申请人提供）：拟议的癌症联盟重点关注两种最常见的艾滋病相关癌症的两种病原病毒的传播和感染的干预，即坦桑尼亚的卡波西肉瘤相关人类疱疹病毒（KSHV）和人类乳头瘤病毒（HPV）。该联盟的目标是通过将在这些领域具有记录优势的合作伙伴联系起来，加强艾滋病恶性肿瘤研究基础设施的三个关键组成部分——病毒学、流行病学和临床护理。除了获得与艾滋病相关的恶性肿瘤的关键数据外，该联盟还将提供多样化的培训机会，以增加当地的专业知识和转让技术。总体而言，这种伙伴关系最终将导致建立技术和人员基础设施的交流 进行坦桑尼亚迫切需要的高质量生物医学、行为和预防性生物医学研究所必需的。将追求四个具体目标：1）通过长期分子癌症流行病学培训机会建设联盟的研究能力，长期培训可授予流行病学和分子肿瘤病毒学两个博士学位、分子肿瘤病毒学硕士学位和癌症流行病学公共卫生硕士学位。 2) 通过在美国的短期技术培训和针对研究人员、临床医生和公共卫生人员的国内研讨会，加强现有的癌症研究能力。 3) 开发分子病毒学研究实验室组成部分和流行病学/生物统计学核心设施，以支持分子癌症流行病学研究项目。 4) 通过支持关于两种最流行的艾滋病相关恶性肿瘤（KS 和宫颈癌）的两个假设驱动的研究项目，支持坦桑尼亚研究团队的发展并提高研究生产力。该拟议项目是独特且具有重大影响的，因为它建立在撒哈拉以南非洲正在成功进行的 Fogarty 项目和 NCI 培训项目的基础上，将其扩展为真正的跨学科研究和培训项目，具有不同的培训轨道和国内研究项目，与坦桑尼亚和美国研究人员合作，对 KS、宫颈癌及其各自的病因进行假设驱动的研究。