Western Regional Center of Excellence for Biodefense and Emerging Infectious Dise

西部地区生物防御和新发传染病卓越中心

• 批准号: 8440786
• 负责人: DAVID H WALKER
• 金额: $ 788.59万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-04 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8440786
• 关键词: Address; Arkansas; Bacteria; Basic Science; Categories; Communicable Diseases; Consultations; Development; Diagnostic; Disease; Disease Outbreaks; Educational workshop; Emergency Situation; Emerging Communicable Diseases; Ensure; Evaluation; Event; Funding; Goals; Grant; Infectious Diseases Research; Infrastructure Activities; Institution; Knowledge; Laboratories; Legal patent; Louisiana; Medical; Mission; New Mexico; Oklahoma; Organism; Pharmaceutical Preparations; Primates; Process; Progress Reports; RNA Viruses; Readiness; Research; Research Activity; Research Personnel; Research Project Grants; Science; Scientist; Site Visit; Source; Staging; Sum; Texas; Therapeutic Agents; Translating; Translational Research; Universities; Vaccines; Veterinary Schools; Virus Diseases; biodefense; meetings; product development; programs; response; stem; success; therapeutic vaccine; vaccine development

The mission of the Western Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research (WRCE) is the creation of synergistic,.multifaceted research, strong infrastructure, and activities to develop vaccines, therapeutics, and diagnostics against natural and manmade emerging infectious disease threats by applying the best basic and translational science. Scientists from 22 institutions propose to conduct 15 major research projects and provide six supportive core activities. The WRCE is a unifying force in Texas, New Mexico, Oklahoma, Arkansas, and Louisiana for collaborative research on infectious diseases. The evaluation of the national RCE program revealed that the WRCE was the top performer in the number of new investigators in biodefense, number of projects, number of organisms studied, number of patents filed, and number of new projects supported by other funds that stemmed from RCE projects. Successful basic scientists with substantial expertise in Category A-C agents have truly embraced the unfamiliar goal of translational product-oriented research. The 15 major projects address four themes: development of therapeutic agents for RNA viruses, platforms for multiplexed diagnostics for Category A-C agents and emerging agents, vaccine development for arboviral and emerging viral diseases, and vaccine development for diseases caused by intracellular bacteria. The 15 projects are currently pursuing new specific aims; this is a result of the WRCE's strategy in the previous grant cycle to support developmental type grants to initiate next-stage projects, and an early competition for major projects one year before the completion of the cycle. This planning process allowed selection of the best, most relevant science and development of synergistic interactions within the themes. Attentive guidance by the administrative core's analysis of progress reports, site visits, regional meetings, workshops, and formal external product development consultations support research activities, along with monthly theme meetings to ensure the continued success of projects. Highly productive scientists utilize such regional sources as three national primate research centers, 19 institutions with BSL-3 laboratories, two institutions with BSL-4 laboratories, two vaccine development centers, two DOE national laboratories, 13 participating medical universities, three participating veterinary schools, and four institutions with aerobiology expertise to translate their outstanding scientific knowledge into program that delivers more than the sum of its parts.

西部地区生物防御和新兴传染病研究卓越中心（WRCE）的使命是创造协同，多方面的研究，强大的基础设施和活动，通过应用最好的基础和转化科学来开发疫苗，治疗和诊断，以应对自然和人为的新兴传染病威胁。来自22个机构的科学家提议开展15个重大研究项目，并提供6项支持性核心活动。WRCE是德克萨斯州、新墨西哥州、俄克拉荷马州、阿肯色州和路易斯安那州传染病合作研究的统一力量。对国家RCE计划的评估显示，WRCE在生物防御新研究人员数量、项目数量、研究的生物体数量、申请的专利数量以及由RCE项目产生的其他基金支持的新项目数量方面表现最好。成功的基础科学家在A-C类代理方面拥有丰富的专业知识，他们真正接受了转化产品导向研究的陌生目标。15个主要项目涉及四个主题：RNA病毒治疗剂的开发，A-C类病原体和新兴病原体的多重诊断平台，虫媒病毒和新兴病毒性疾病的疫苗开发，以及细胞内细菌引起的疾病的疫苗开发。这15个项目目前正在追求新的具体目标;这是由于水资源环境委员会在上一个赠款周期中的战略，即支持发展型赠款，以启动下一阶段的项目，并在该周期结束前一年提前竞争主要项目。这一规划过程允许选择最好的、最相关的科学和发展主题内的协同互动。行政核心对进度报告的分析、现场访问、区域会议、讲习班和正式的外部产品开发协商提供了认真的指导，沿着每月的主题会议，以确保项目的持续成功。高生产力的科学家利用这些区域资源，如三个国家灵长类动物研究中心，19个机构与BSL-3实验室，两个机构与BSL-4实验室，两个疫苗开发中心，两个能源部国家实验室，13个参与医科大学，三个参与兽医学校，和四个具有空气生物学专业知识的机构，将他们杰出的科学知识转化为计划，提供超过其部分的总和。

项目成果

VIPR HMM: a hidden Markov model for detecting recombination with microbial detection microarrays.

VIPR HMM：一种隐马尔可夫模型，用于通过微生物检测微阵列检测重组。

• DOI: 10.1093/bioinformatics/bts560
• 发表时间: 2012
• 期刊: Bioinformatics (Oxford, England)
• 作者: Allred,AdamF;Renshaw,Hilary;Weaver,Scott;Tesh,RobertB;Wang,David
• 通讯作者: Wang,David

Nature of allosteric inhibition in glutamate racemase: discovery and characterization of a cryptic inhibitory pocket using atomistic MD simulations and pKa calculations.

• DOI: 10.1021/jp201037t
• 发表时间: 2011-04-07
• 期刊: JOURNAL OF PHYSICAL CHEMISTRY B
• 影响因子: 3.3
• 作者: Whalen, Katie L.;Tussey, Kenneth B.;Blanke, Steven R.;Spies, M. Ashley
• 通讯作者: Spies, M. Ashley

Mechanism of inhibition of Bacillus anthracis spore outgrowth by the lantibiotic nisin.

• DOI: 10.1021/cb1004178
• 发表时间: 2011-07-15
• 期刊: ACS CHEMICAL BIOLOGY
• 影响因子: 4
• 作者: Gut, Ian M.;Blanke, Steven R.;van der Donk, Wilfred A.
• 通讯作者: van der Donk, Wilfred A.

Nipah Virus C Protein Recruits Tsg101 to Promote the Efficient Release of Virus in an ESCRT-Dependent Pathway.

• DOI: 10.1371/journal.ppat.1005659
• 发表时间: 2016-05
• 期刊: PLoS pathogens
• 影响因子: 6.7
• 作者: Park A;Yun T;Vigant F;Pernet O;Won ST;Dawes BE;Bartkowski W;Freiberg AN;Lee B
• 通讯作者: Lee B

RepliVAX WN, a single-cycle flavivirus vaccine to prevent West Nile disease, elicits durable protective immunity in hamsters.

RepliVAX WN 是一种预防西尼罗河病的单周期黄病毒疫苗，可在仓鼠中激发持久的保护性免疫力。

• DOI: 10.1016/j.vaccine.2009.07.016
• 发表时间: 2009
• 期刊: Vaccine
• 影响因子: 5.5
• 作者: Widman,DouglasG;Ishikawa,Tomohiro;Winkelmann,EvandroR;Infante,Ernesto;Bourne,Nigel;Mason,PeterW
• 通讯作者: Mason,PeterW