Creating a computerized self-administered version of Comprehensive Behavioral Int

创建综合行为智能的计算机化自我管理版本

• 批准号: 8648060
• 负责人: Michael B Himle
• 金额: $ 57.08万
• 依托单位: PSYC TECH, LTD
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8648060
• 关键词: Address; Adrenergic Agonists; Adverse effects; Adverse event; Age; Antipsychotic Agents; Area; Award; Behavior Therapy; Behavioral; Child; Chronic; Clinical; Clinical Trials; Comorbidity; Computers; Data; Development; Disease; Dose; Family; Feedback; Fees; Frequencies; Gilles de la Tourette syndrome; Habits; Impairment; Individual; Internet; Intervention; Lead; Marketing; Measures; Medication Management; Modeling; Monitor; Motor Tics; Parents; Participant; Patients; Pattern; Pharmaceutical Preparations; Pharmacological Treatment; Pharmacotherapy; Phase; Pilot Projects; Process; Protocols documentation; Provider; Quality of life; Randomized Clinical Trials; Randomized Controlled Trials; Relaxation Therapy; Research; Resources; School-Age Population; Self-Administered; Severities; Site; Small Business Innovation Research Grant; Strategic Planning; Symptoms; Testing; Therapeutic; Tic disorder; Time; Training; Travel; Visit; Vocal Tics; Work; active method; base; commercialization; comparative efficacy; computerized; cost; cost effective; efficacy testing; follow-up; impression; improved; indexing; innovation; neuropsychiatry; preference; programs; prototype; psychosocial; public health relevance; response; satisfaction; secondary outcome; self help; social; usability

Project Summary/Abstract This Phase II SBIR proposes to expand upon our successful Phase I activities to finalize development and test the efficacy of an innovative computer-based treatment-delivery product for children with Chronic Tic Disorders (CTD; including Tourette Disorder) and their families. CTD represents a class of neuropsychiatric disorders, occurring in 0.6-3% of school-aged children that can lead to significant impairments in physical, social, academic, and interpersonal functioning and reduced quality of life. Currently, there is no cure for CTD, however in large-scale randomized controlled trials, a non-pharmacological treatment known as Comprehensive Behavioral Interventions for Tics (CBIT) was shown to reduce tics without the adverse side effects associated with pharmacotherapy. A therapist-guided, empirically validated CBIT protocol is available, however the vast majority of individuals who desire CBIT do not have access to therapists trained in the delivery of this intervention. Given the need for non-pharmacological treatment options for children with CTD, a desire for such treatments by potential end-users, and the absence of practitioners adequately trained in the treatment, there is a clear need for innovative modes of dissemination. Following our recently completed (and successful) Phase I project, the current proposal partners two of the primary developers of the CBIT intervention with PsycTech Ltd., to finalized development and test a highly accessible and relatively inexpensive computerized self-help version of CBIT. Results from our Phase I project demonstrated that a prototype version of TICHELPER received high ratings from both professionals and end-users (children with CTD and their parents) on indices of feasibility, acceptability, and usability. Results from the Phase I pilot study also show that TICHELPER was effective for reducing core CTD symptoms. Phase I results strongly justify Phase II, during which we will fully develop and test the efficacy of TicHelper. This Phase II proposal aims to (1) use an iterative feedback process with end-users to develop the remaining core components of the CBIT protocol (i.e., relaxation training, function-based intervention, and the fully developed habit reversal module to address core CTD symptoms) into a self-administered online format, and (2) to compare the efficacy of TICHELPER to an Internet-Based Resources (IBR) condition in a randomized controlled trial. !

项目摘要/摘要 II阶段SBIR建议扩展我们成功的I期活动，以最终确定开发和测试 慢性疾病儿童的创新基于计算机的治疗产品的功效 （CTD；包括图雷特障碍）及其家人。 CTD代表一类神经精神疾病， 发生在0.6-3％的学龄儿童中，可能导致身体，社会， 学术和人际关系功能和生活质量降低。目前，CTD无法治愈， 但是，在大规模的随机对照试验中，一种非药物治疗 显示抽动（CBIT）的全面行为干预措施可减少无侧面的抽动 与药物治疗相关的影响。可以使用经过治疗师引导，经验验证的CBIT协议， 但是，绝大多数渴望CBIT的人无法获得接受培训的治疗师 提供此干预措施。考虑到需要CTD儿童的非药物治疗选择， 潜在的最终用户对这种治疗的渴望，以及在没有经过培训的从业者的缺乏 治疗清楚地需要创新的传播方式。遵循我们最近完成的（和 成功）I期项目，当前的提案合作伙伴CBIT的两个主要开发人员 与Psyctech Ltd.的干预，以最终确定开发并测试高度访问和相对较高的 廉价的计算机自助版CBIT。我们阶段I项目的结果证明了 Tichelper的原型版本获得了专业人士和最终用户的高评级（患有 CTD及其父母）关于可行性，可接受性和可用性的指标。第一阶段试点研究的结果 还表明Tichelper可有效减少核心CTD症状。第一阶段的结果强烈合理 第二阶段，在此期间，我们将充分开发和测试Tichelper的功效。该第二阶段提案的目的是 （1）使用最终用户的迭代反馈过程来开发CBIT的剩余核心组件 协议（即放松训练，基于功能的干预措施以及完全开发的习惯逆转模块 将核心CTD症状）介绍为自我管理的在线格式，（2）比较 在一项随机对照试验中，基于Internet的资源（IBR）条件的Tichelper。 呢