Virtual Emergency Medical Technician-Basic Training Program

描述（由申请人提供）：ZetrOZ 开发了一种新型、微型、便携式、高功率、用于伤口愈合的超声系统原型。伤口愈合是一个主要的临床问题，当伤口是由于外伤、烧伤、手术或由于更慢性的健康问题而发生的急性伤口时，伤口愈合可能会带来重大的临床挑战。伤口愈合是修复受伤后受损组织的复杂纤维增殖反应。这个过程很脆弱，容易中断或失败，导致伤口无法愈合。从历史上看，伤口一直以次优的方式进行治疗，使用旨在覆盖伤口和吸收渗出物的基本伤口护理产品。超声波（一种安全、常用、经 FDA 批准的治疗方式）已被证明对体外和体内动物模型中与组织愈合相关的因素具有有益的影响，包括促进组胺释放、血管生成和胶原蛋白沉积（从而增加伤口断裂强度），并最终导致伤口尺寸减小。尽管超声波疗法之前已被证明可以加速伤口愈合，但传统技术采用较短的高强度治疗脉冲。这种治疗通常仅限于由医疗提供者施用。与当前技术相比，我们的设备与传统超声设备相比，显着降低了超声治疗的尺寸、成本和功率要求。该系统可以在比传统超声系统更低的电压下提供治疗性声能波。在这个项目中，我们的目标是证明人类可穿戴低强度治疗超声系统可以增强伤口愈合。这将通过在动物尸体上对单次电池充电的系统进行测试来实现。我们还将证明低强度治疗性超声可改善伤口愈合，这是通过对野生型和糖尿病小鼠切除伤口模型中上皮化和肉芽组织形成（人类伤口愈合的主要组成部分）的速率和程度进行治疗来测量的。拟议的实验将研究两种不同的功率水平，以进一步了解强度对伤口愈合的影响。

DESCRIPTION (provided by applicant): ZetrOZ has developed a prototype novel, miniature, portable, high-power, ultrasound system for would healing. Wound healing is a major clinical issue, and can present significant clinical challenges both when wounds are acute--occurring due to trauma, burns, surgery, or due to more chronic health problems. Wound healing is an intricate fibroproliferative response to repairs damaged tissue following injury. This process is fragile and susceptible to interruption or failure, leading to non-healing wounds. Historically, wounds have been historically treated in a sub-optimal fashion with basic wound care products designed to cover wounds and absorb exudates. Ultrasound (a safe, commonly used, FDA-approved treatment modality) has been shown to have beneficial effects on factors associated with tissue healing in both in vitro and in vivo animal models, including promotion of histamine release, angiogenesis, and collagen deposition (thereby increasing wound breaking strength), and ultimately results in a reduction in wound size. Although ultrasound therapy has been previously demonstrated to accelerate wound healing, conventional techniques utilize shorter bursts of high-intensity treatments. Such treatment is typically limited to administration by a medical provider. In contrast to current technologies, our device significantly reduces the size, cost, and power requirements of ultrasound therapy when compared to traditional ultrasound devices. The system can deliver therapeutic acoustical energy waves at lower voltages than those in conventional ultrasound systems. During this project we aim to demonstrate that a human wearable low intensity therapeutic ultrasound system enhances wound healing. This will be accomplished through testing the system on a single battery charge in an animal cadaver. We will also demonstrate that low intensity therapeutic ultrasound improves wound healing, as measured by therapy on the rate and extent of epithelialization and granulation tissue formation (the major components in human wound healing) in wild-type and diabetic murine excisional wound models. The proposed experiments will investigate two different power levels to further understand impact of intensity on would healing.