Virtual Emergency Medical Technician-Basic Training Program

描述(申请人提供)：ZetrOZ已开发出一种新颖、微型、便携式、高功率、用于Will治疗的超声系统原型。伤口愈合是一个重大的临床问题，无论是由于创伤、烧伤、手术或更长期的健康问题，当伤口是急性时，伤口愈合都可能带来重大的临床挑战。伤口愈合是损伤后修复受损组织的一种复杂的纤维增殖性反应。这一过程是脆弱的，容易受到干扰或失败，导致无法愈合的伤口。从历史上看，伤口的治疗一直是以次优的方式进行的，基本的伤口护理产品旨在覆盖伤口并吸收渗出物。超声波(一种安全、常用、FDA批准的治疗方法)已被证明在体外和体内动物模型中对与组织愈合相关的因素具有有益的影响，包括促进组胺释放、血管生成和胶原沉积(从而增加伤口破裂强度)，最终导致伤口缩小。虽然超声波治疗以前已经被证明可以加速伤口愈合，但传统技术使用的是短时间的高强度治疗。这种治疗通常仅限于由医疗提供者进行管理。与目前的技术相比，我们的设备与传统的超声设备相比，显著降低了超声治疗的尺寸、成本和功率要求。该系统可以在比传统超声系统更低的电压下提供治疗性声能波。在这个项目中，我们的目标是证明人类可穿戴的低强度治疗性超声波系统可以促进伤口愈合。这将通过在动物身体上对该系统进行一次电池充电来实现。我们还将通过对野生型和糖尿病小鼠切除伤口模型中上皮化和肉芽组织形成(人类伤口愈合的主要成分)的治疗来衡量低强度治疗性超声波促进伤口愈合。拟议中的实验将调查两种不同的功率水平，以进一步了解强度对Will愈合的影响。

DESCRIPTION (provided by applicant): ZetrOZ has developed a prototype novel, miniature, portable, high-power, ultrasound system for would healing. Wound healing is a major clinical issue, and can present significant clinical challenges both when wounds are acute--occurring due to trauma, burns, surgery, or due to more chronic health problems. Wound healing is an intricate fibroproliferative response to repairs damaged tissue following injury. This process is fragile and susceptible to interruption or failure, leading to non-healing wounds. Historically, wounds have been historically treated in a sub-optimal fashion with basic wound care products designed to cover wounds and absorb exudates. Ultrasound (a safe, commonly used, FDA-approved treatment modality) has been shown to have beneficial effects on factors associated with tissue healing in both in vitro and in vivo animal models, including promotion of histamine release, angiogenesis, and collagen deposition (thereby increasing wound breaking strength), and ultimately results in a reduction in wound size. Although ultrasound therapy has been previously demonstrated to accelerate wound healing, conventional techniques utilize shorter bursts of high-intensity treatments. Such treatment is typically limited to administration by a medical provider. In contrast to current technologies, our device significantly reduces the size, cost, and power requirements of ultrasound therapy when compared to traditional ultrasound devices. The system can deliver therapeutic acoustical energy waves at lower voltages than those in conventional ultrasound systems. During this project we aim to demonstrate that a human wearable low intensity therapeutic ultrasound system enhances wound healing. This will be accomplished through testing the system on a single battery charge in an animal cadaver. We will also demonstrate that low intensity therapeutic ultrasound improves wound healing, as measured by therapy on the rate and extent of epithelialization and granulation tissue formation (the major components in human wound healing) in wild-type and diabetic murine excisional wound models. The proposed experiments will investigate two different power levels to further understand impact of intensity on would healing.