Virtual Emergency Medical Technician-Basic Training Program

描述（由申请人提供）：ZetrOZ开发了一种用于伤口愈合的新型、微型、便携式、高功率超声系统原型。伤口愈合是一个主要的临床问题，无论是在急性伤口（由于创伤、烧伤、手术或由于更慢性的健康问题而发生）时，都会带来重大的临床挑战。伤口愈合是损伤后修复受损组织的复杂纤维增生反应。这个过程是脆弱的，容易中断或失败，导致无法愈合的伤口。历史上，伤口一直以次优的方式用设计成覆盖伤口和吸收渗出物的基本伤口护理产品进行治疗。超声波（一种安全、常用、FDA批准的治疗方式）已被证明对体外和体内动物模型中与组织愈合相关的因素具有有益作用，包括促进组胺释放、血管生成和胶原蛋白沉积（从而增加伤口断裂强度），并最终导致伤口尺寸减小。尽管超声治疗先前已被证明可加速伤口愈合，但常规技术利用较短的高强度治疗脉冲。这种治疗通常限于由医疗提供者施用。与现有技术相比，与传统超声设备相比，我们的设备显著降低了超声治疗的尺寸、成本和功率要求。该系统可以在比传统超声系统更低的电压下传递治疗声能波。在该项目中，我们的目标是证明人类可穿戴低强度治疗超声系统可以增强伤口愈合。这将通过在动物尸体上对系统进行单次电池充电测试来实现。我们还将证明，低强度治疗性超声波可改善伤口愈合，通过治疗野生型和糖尿病小鼠切除伤口模型中上皮形成和肉芽组织形成（人类伤口愈合的主要成分）的速率和程度进行测量。拟议的实验将研究两种不同的功率水平，以进一步了解强度对伤口愈合的影响。

DESCRIPTION (provided by applicant): ZetrOZ has developed a prototype novel, miniature, portable, high-power, ultrasound system for would healing. Wound healing is a major clinical issue, and can present significant clinical challenges both when wounds are acute--occurring due to trauma, burns, surgery, or due to more chronic health problems. Wound healing is an intricate fibroproliferative response to repairs damaged tissue following injury. This process is fragile and susceptible to interruption or failure, leading to non-healing wounds. Historically, wounds have been historically treated in a sub-optimal fashion with basic wound care products designed to cover wounds and absorb exudates. Ultrasound (a safe, commonly used, FDA-approved treatment modality) has been shown to have beneficial effects on factors associated with tissue healing in both in vitro and in vivo animal models, including promotion of histamine release, angiogenesis, and collagen deposition (thereby increasing wound breaking strength), and ultimately results in a reduction in wound size. Although ultrasound therapy has been previously demonstrated to accelerate wound healing, conventional techniques utilize shorter bursts of high-intensity treatments. Such treatment is typically limited to administration by a medical provider. In contrast to current technologies, our device significantly reduces the size, cost, and power requirements of ultrasound therapy when compared to traditional ultrasound devices. The system can deliver therapeutic acoustical energy waves at lower voltages than those in conventional ultrasound systems. During this project we aim to demonstrate that a human wearable low intensity therapeutic ultrasound system enhances wound healing. This will be accomplished through testing the system on a single battery charge in an animal cadaver. We will also demonstrate that low intensity therapeutic ultrasound improves wound healing, as measured by therapy on the rate and extent of epithelialization and granulation tissue formation (the major components in human wound healing) in wild-type and diabetic murine excisional wound models. The proposed experiments will investigate two different power levels to further understand impact of intensity on would healing.