Murine GI Surgical Modeling Core

GI手术建模核心提供独特的小鼠手术服务（减肥和其他新颖的手术程序）。设立这一核心是为了加强刚果民主共和国调查人员的调查工作，并提供否则不可行的研究途径。核心的主要原因在于越来越多的小鼠具有与消化系统疾病相关或潜在相关的遗传改变，并且需要外科和实验技术来研究遗传（或药理学）操作的影响。为了研究健康的、没有压力的老鼠，这个过程需要技巧和实践。核心拥有熟练的外科医生，能够适应VDDRC成员的特定需求，包括减肥外科手术，巴雷特食管和肝脏移植手术模型以及缺血/再灌注损伤模型。使用外科模型获得的结果的质量直接关系到动物的总体健康。Core非常重视提供没有可避免的、不希望出现的并发症的小鼠模型。术前和术后护理对手术的成功和手术本身一样重要。核心的总体目标是提供小鼠减肥手术模型，使用旨在反映人类，肝移植和适应VDDRC成员需求的独特定制手术模型的程序。实现这一目标的核心是：

The GI Surgical Modeling Core provides unique murine surgical services (bariatric and other novel surgical procedures). This core was established to enhance the investigative efforts of the VDDRC investigators and provide avenues of research that otherwise would not be feasible. The primary rational for the core rests in the growing number of mice having genetic alterations with relevance or potential relevance to digestive diseases and the need for surgical and experimental techniques that are necessary to study the impact of genetic (or pharmacologic) manipulations. The procedures require skill and practice in order to study healthy, unstressed mice. The core has skilled surgeons that are capable of adapting a range of procedures to suit specific needs of VDDRC members including bariatric surgical procedures, surgical models for Barrett's esophagus and liver transplantation and ischemia/reperfusion injury models. The quality of the results that are obtained using surgical models is directly related to the general health of the animal. The Core has placed significant emphasis on providing murine models that are free of avoidable, undesired complications. Pre and post-operative care is as important to the success of the procedure as the surgical procedure itself. The overall goal of the core is to provide murine models of bariatric surgery using procedures that are designed to reflect those performed in humans, liver transplantation, and unique customized surgical models adapted to the needs of VDDRC members. To achieve this goal the core: 1. Provides mouse bariatric surgery models with application to basic and translational research. 2. Provides mouse models of Barrett's esophagus and liver and small bowel transplantation. 3. Provides peri-operative care to ensure that animals are healthy and free of undue stress. 4. Trains investigators in specialized surgical procedures. 5. Responds to the needs of VDDRC investigators through development of new procedures. The Core interacts closely with other VDDRC Cores, the Mouse Metabolic Phenotyping Center (MMPC), the Diabetes Research and Training Center, and the Division of Animal Care to ensure and maximize efficient use of resources and personnel and enhance interdisciplinary collaboration.