Vanderbilt Mouse Metabolic Phenotyping Center

范德比尔特小鼠代谢表型中心

• 批准号: 7930013
• 负责人: DAVID H WASSERMAN
• 金额: $ 52.76万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-28 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7930013
• 关键词: Vanderbilt; Mouse; Metabolic; Phenotyping; Center

DESCRIPTION, OVERALL (provided by applicant): The Vanderbilt Mouse Metabolic Phenotyping Center (VMMPC) was founded in 2001 to advance medical and biological research by providing the scientific community with standardized, high quality phenotyping services for mouse models of diabetes, diabetic complications, and obesity. The VMMPC consists of five cores. The Administrative Core provides scientific, financial, and administrative leadership, and interacts with NIH program officials and the National Executive Steering Committee. The Administrative Core also oversees service requests, data management, and tracks mice studied at the VMMPC. The Animal Care and Welfare Core evaluates mice submitted to the VMMPC for any pathology, oversees the health and welfare of the colony, and ensures compliance with animal use regulatory bodies and the National MMPC Animal Care and Use Committee. The Metabolic Pathophysiology (MPC), the Cardiovascular Pathophysiology and Complications (CPCC), and the Analytical Resources (ARC) Core Laboratories perform the phenotyping procedures. Services provided by the MPC emphasize methodology to study energy balance, insulin action, hormone secretion, and metabolism in the conscious, unstressed mouse. The MPC also has the capacity to assess organ or islet function in isolation and can apply state-of-the-art imaging techniques. The CPCC has comprehensive non-invasive and minimally invasive testing for cardiovascular disease and other complications of diabetes. The ARC receives samples generated from VMMPC testing and from experiments conducted outside the VMMPC. Analyses performed by this core are specific to the mouse and are scaled to accommodate the small sample volumes obtained from the mouse. The VMMPC exists because of the insight of leadership at the NIDDK, a generous commitment of space and resources from VUMC, and a well-conceived infrastructure. But the main reason the VMMPC works as well as it does is the people that comprise it. This NIDDK experiment in mouse phenotyping requires a faculty that is willing to make technology that is part of their research lifeline available to the scientific community for no more than the recovery of costs and the knowledge that they are working for a greater good. It requires a staff that is so skilled and committed that scientists are willing to entrust their mice, their research lifelines, with them.

总体描述（由申请人提供）： 范德比尔特小鼠代谢表型中心（VMMPC）成立于2001年，旨在通过为科学界提供糖尿病、糖尿病并发症和肥胖小鼠模型的标准化、高质量表型服务来推进医学和生物学研究。VMMPC由五个核心组成。行政核心提供科学，财务和行政领导，并与NIH项目官员和国家执行指导委员会互动。管理核心还监督服务请求、数据管理，并跟踪VMMPC研究的小鼠。动物护理和福利中心评估提交给VMMPC的小鼠的任何病理学，监督殖民地的健康和福利，并确保符合动物使用监管机构和国家MMPC动物护理和使用委员会的要求。代谢病理生理学（MPC）、心血管病理生理学和并发症（CPCC）和分析资源（ARC）核心实验室执行表型分析程序。MPC提供的服务强调研究清醒、无压力小鼠的能量平衡、胰岛素作用、激素分泌和代谢的方法。MPC还具有单独评估器官或胰岛功能的能力，并可以应用最先进的成像技术。CPCC对心血管疾病和其他糖尿病并发症进行全面的无创和微创检测。ARC接收VMMPC测试和VMMPC外部进行的实验生成的样本。通过该核心进行的分析是特定于小鼠的，并按比例调整以适应从小鼠获得的小样品体积。VMMPC的存在是因为NIDDK领导层的洞察力，VUMC对空间和资源的慷慨承诺，以及精心设计的基础设施。但VMMPC之所以能发挥作用，主要原因在于它的组成人员。NIDDK在小鼠表型分析方面的实验需要一个愿意将其研究生命线的一部分技术提供给科学界的教师，而不仅仅是收回成本和他们正在为更大的利益而工作的知识。它需要一个如此熟练和忠诚的工作人员，以至于科学家们愿意把他们的老鼠，他们的研究生命线，托付给他们。