Vanderbilt Mouse Metabolic Phenotyping Center

范德比尔特小鼠代谢表型中心

• 批准号: 7930013
• 负责人: DAVID H WASSERMAN
• 金额: $ 52.76万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-28 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7930013
• 关键词: Vanderbilt; Mouse; Metabolic; Phenotyping; Center

DESCRIPTION, OVERALL (provided by applicant): The Vanderbilt Mouse Metabolic Phenotyping Center (VMMPC) was founded in 2001 to advance medical and biological research by providing the scientific community with standardized, high quality phenotyping services for mouse models of diabetes, diabetic complications, and obesity. The VMMPC consists of five cores. The Administrative Core provides scientific, financial, and administrative leadership, and interacts with NIH program officials and the National Executive Steering Committee. The Administrative Core also oversees service requests, data management, and tracks mice studied at the VMMPC. The Animal Care and Welfare Core evaluates mice submitted to the VMMPC for any pathology, oversees the health and welfare of the colony, and ensures compliance with animal use regulatory bodies and the National MMPC Animal Care and Use Committee. The Metabolic Pathophysiology (MPC), the Cardiovascular Pathophysiology and Complications (CPCC), and the Analytical Resources (ARC) Core Laboratories perform the phenotyping procedures. Services provided by the MPC emphasize methodology to study energy balance, insulin action, hormone secretion, and metabolism in the conscious, unstressed mouse. The MPC also has the capacity to assess organ or islet function in isolation and can apply state-of-the-art imaging techniques. The CPCC has comprehensive non-invasive and minimally invasive testing for cardiovascular disease and other complications of diabetes. The ARC receives samples generated from VMMPC testing and from experiments conducted outside the VMMPC. Analyses performed by this core are specific to the mouse and are scaled to accommodate the small sample volumes obtained from the mouse. The VMMPC exists because of the insight of leadership at the NIDDK, a generous commitment of space and resources from VUMC, and a well-conceived infrastructure. But the main reason the VMMPC works as well as it does is the people that comprise it. This NIDDK experiment in mouse phenotyping requires a faculty that is willing to make technology that is part of their research lifeline available to the scientific community for no more than the recovery of costs and the knowledge that they are working for a greater good. It requires a staff that is so skilled and committed that scientists are willing to entrust their mice, their research lifelines, with them.

总体描述(由申请人提供)： 范德比尔特小鼠代谢表型中心(VMMPC)成立于2001年，旨在通过为科学界提供糖尿病、糖尿病并发症和肥胖症小鼠模型的标准化、高质量表型服务来推动医学和生物学研究。VMMPC由五个核心组成。行政核心提供科学、财务和行政领导，并与NIH项目官员和国家执行指导委员会互动。管理核心还监督服务请求、数据管理，并跟踪在VMMPC研究的MICE。动物保护和福利核心对提交给VMMPC的老鼠进行任何病理评估，监督殖民地的健康和福利，并确保遵守动物使用监管机构和国家MMPC动物保护和使用委员会的规定。代谢病理生理学(MPC)、心血管病理生理学和并发症(CPCC)以及分析资源(ARC)核心实验室执行表型程序。MPC提供的服务强调研究清醒、无应激小鼠的能量平衡、胰岛素作用、激素分泌和新陈代谢的方法论。MPC还具有单独评估器官或胰岛功能的能力，并可以应用最先进的成像技术。CPCC对心血管疾病和其他糖尿病并发症进行全面的非侵入性和微创性检测。ARC接收从VMMPC测试和在VMMPC外部进行的实验中生成的样本。此核心执行的分析是特定于鼠标的，并进行了缩放以适应从鼠标获得的小样本量。VMMPC的存在是因为NIDDK的领导层的洞察力，VUMC对空间和资源的慷慨承诺，以及精心设计的基础设施。但VMMPC运作良好的主要原因是组成它的人。NIDDK在小鼠表型鉴定方面的实验需要一支愿意将作为他们研究生命线一部分的技术提供给科学界的教师，他们只需收回成本，并知道他们正在为更大的利益而工作。它需要一支技术娴熟、尽职尽责的工作人员，以至于科学家们愿意将他们的老鼠、他们的研究生命线委托给他们。