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A Multi-'omic Analysis of the Vaginal Microbiome during Pregnancy

怀孕期间阴道微生物组的多组学分析

基本信息

批准号：
8731192
负责人：
Gregory Allen Buck
金额：
$ 250万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-06 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8731192
关键词：
Abdominal colic Accounting Address Bacteria Bacterial Genome Birth Cells Clinic Controlled Environment Data Databases Developed Countries Development Disease Enrollment Environment Female Fetus Funding Generations Genes Genitourinary system Genomics Gestational Diabetes Health Health Care Costs Human Microbiome Human body Immune Immune response Incidence Individual Infant Infection Inflammation Lead Life Low Birth Weight Infant Maintenance Maps Measures Mediating Metabolic Metagenomics Microbe Morbidity - disease rate Necrotizing Enterocolitis Neonatal Newborn Infant Organism Outcome Participant Pathway interactions Play Population Population Study Postnatal Care Pregnancy Pregnancy Outcome Pregnant Women Premature Birth Premature Infant Premature Labor Premature Rupture Fetal Membranes Prenatal care Proteomics Recombinant DNA Regulatory Pathway Research Personnel Risk Role Sampling Shotgun Sequencing Signal Pathway Survival Rate System Taxonomy Technology Testing Uterine cavity Vagina Woman Women&apos s Health cohort cytokine fetal genome sequencing human female improved infant morbidity/mortality insight interest metabolomics microbial microbiome microorganism mortality neonatal morbidity neonate perinatal health premature prenatal health prevent protein protein interaction rRNA Genes stillbirth transcriptomics

项目摘要

In the U.S., the annual cost of health care for newborns with complications approaches $26 billion, and worldwide, preterm birth is the leading cause of morbidity and mortality among neonates. Despite improved survival rates, the past few decades have seen no significant decrease in preterm births. It is becoming more clear that the billions of bacteria that colonize the human body play important roles in the health of the individual. However, the role of the millions of bacteria and other microbes that colonize the human female urogenital tract in prenatal health and birth of a healthy baby remains obscure. Previous to the recent development of 'omics' technologies; i.e., genomics, transcriptomics, proteomics, metabolomics, interactomics, etc., it was not possible to study these microbial populations in any in depth or highly efficient way. Many of these organisms have never been characterized and a fairly large fraction have not been successfully cultured. Herein, we propose to use these 'omic' technologies to dissect the bacterial populations that inhabit and colonize the female urogenital tract of pregnant women to assess the role(s) of these organisms in maintenance of health or in the cause of disease in these women and their babies. An understanding of the roles these organisms play in the health of the female urogenital tract will lead to better, more efficient prenatal and postnatal care, likely leading to diminished levels of preterm birth and infant morbidity and mortality.

在美国，每年用于新生儿并发症的医疗费用接近260亿美元