Summit on Systems Biology: Integrating Basic and Clinical Research

描述（由申请人提供）： 虽然还原实验将继续成为生物医学研究的支柱， 从近期来看，系统生物学方法代表了未来科学的先锋。 有效地使用基于系统的方法可以在更大的层次结构中确定背景， 实验结果和揭示关系是隐藏的还原实验主义者。 这次会议的目的是吸引带头的科学先锋申请 生物学和生物医学问题的系统方法，并提供一个有效的论坛 以便向生物医学研究界更广泛地传播这些战略。最终 本次会议的一天将包括“动手”研讨会，介绍计算和 相关的工具，感兴趣的研究人员。具体而言，会议旨在： 1.将系统方法应用于基础生物医学的领导者聚集在一起 与临床和转化研究人员继续对话， 2006年第一次峰会上发起的相互学习。 2.让这些顶尖科学家和政策制定者参与讨论 生物和生物医学研究的系统方法和最迅速 在医学中实施系统方法的方法。 3.深入描述所应用的系统方法的技术 到细胞和亚细胞分析。 4.为临床科学家提供系统应用的深入入门 转化和临床研究的方法。 5.提供系统方法应用方面的实际接触和培训， 基础、临床和转化研究。 最后，由于疾病很少涉及单一系统，诊断和治疗将是 通过整合广泛的数据集而得到显著增强;即，通过应用集成的 系统方法。因此，本次会议的最后一个广泛目的是， 从基础生物学研究到临床和转化的系统方法的进展 研究受众，促进知识交流。

DESCRIPTION (provided by applicant): Although reductive experimentation will continue to be the mainstay of biomedical research in the near term, the systems biology approach represents the vanguard of science for the future. Effective use of a systems-based approach can identify context within a greater hierarchy of experimental results and reveal relationships that are hidden to the reductive experimentalist. The purpose of this meeting is to attract that scientific vanguard leading the charge to apply systems approaches to biological and biomedical problems, and to provide an effective forum for broader dissemination of these strategies to the biomedical research community. The final day of this conference will consist of "hands on" workshops to introduce computational and related tools to interested investigators. Specifically, the conference aims: 1. To bring together the leaders in applying systems approaches to basic biomedical research with those in clinical and translational research to continue the dialogue and mutual learning initiated in the first Summit in 2006. 2. To engage these leading scientists and policymakers in a discussion on the value of a systems approach to biological and biomedical research and on the most expeditious means of implementing the application of the systems approach in medicine. 3. To provide an in depth description of the technologies of systems approaches as applied to cellular and sub-cellular analyses. 4. To provide an in depth initiation of the clinical scientist into the application of systems approaches in translational and clinical research. 5. To provide hands on exposure and training in the applications of systems approaches in basic, clinical and translational research. Finally, since disease rarely involves a single system, diagnosis and treatment would be significantly enhanced by integration of extensive data sets; i.e., by applying an integrated systems approach. The final broad purpose of this conference is, therefore, to bring the recent advances in systems approaches in basic biological research to a clinical and translational research audience and to facilitate the intellectual exchange.