Summit on Systems Biology: Integrating Basic and Clinical Research

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DESCRIPTION (provided by applicant): Although reductive experimentation will continue to be the mainstay of biomedical research in the near term, the systems biology approach represents the vanguard of science for the future. Effective use of a systems-based approach can identify context within a greater hierarchy of experimental results and reveal relationships that are hidden to the reductive experimentalist. The purpose of this meeting is to attract that scientific vanguard leading the charge to apply systems approaches to biological and biomedical problems, and to provide an effective forum for broader dissemination of these strategies to the biomedical research community. The final day of this conference will consist of "hands on" workshops to introduce computational and related tools to interested investigators. Specifically, the conference aims: 1. To bring together the leaders in applying systems approaches to basic biomedical research with those in clinical and translational research to continue the dialogue and mutual learning initiated in the first Summit in 2006. 2. To engage these leading scientists and policymakers in a discussion on the value of a systems approach to biological and biomedical research and on the most expeditious means of implementing the application of the systems approach in medicine. 3. To provide an in depth description of the technologies of systems approaches as applied to cellular and sub-cellular analyses. 4. To provide an in depth initiation of the clinical scientist into the application of systems approaches in translational and clinical research. 5. To provide hands on exposure and training in the applications of systems approaches in basic, clinical and translational research. Finally, since disease rarely involves a single system, diagnosis and treatment would be significantly enhanced by integration of extensive data sets; i.e., by applying an integrated systems approach. The final broad purpose of this conference is, therefore, to bring the recent advances in systems approaches in basic biological research to a clinical and translational research audience and to facilitate the intellectual exchange.