The Influence of HPV on Preterm Birth via Immunomodulation of the Microbiome

HPV 通过微生物组免疫调节对早产的影响

• 批准号: 10264412
• 负责人: Gregory Allen Buck
• 金额: $ 22.11万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10264412
• 关键词: Address; Adult; Affect; Allografting; Anaerobic Bacteria; Asians; Bacterial Vaginosis; Biological Markers; Birth; Birth Rate; Categories; Caucasians; Cellular Immunity; Childhood; DNA Viruses; Diagnostic; Disease; Elements; Epidemiology; Equation; Ethnic group; Etiology; Female; Future; Grant; Growth; Hispanics; Human Papilloma Virus Vaccination; Human Papilloma Virus Vaccine; Human Papillomavirus; Human papilloma virus infection; Immune; Infection; Infectious Agent; Inflammation; Inflammatory; Interleukin-1 alpha; Interleukin-10; Interleukin-6; Intervention; Light; Literature; Logistic Regressions; Low risk HPV; Malignant - descriptor; Mediating; Microbe; Microbiology; Modeling; Morbidity - disease rate; Not Hispanic or Latino; Outcome; Parents; Pregnancy; Premature Birth; Prevalence; Progesterone; Public Health; Race; Reporting; Research; Research Personnel; Risk; Role; Sexually Transmitted Diseases; Structure; Testing; Training; United States; Vaccines; Vagina; Woman; Work; adverse pregnancy outcome; bacteriome; black women; clinical development; clinically significant; cytokine; fetal; health disparity; high risk; immunoregulation; microbial; microbiome; neonatal death; parent grant; pathogenic virus; platelet-derived growth factor BB; pregnant; premalignant; programs; reproductive tract; tool; vaginal microbiome; virome

Summary: This diversity supplement relates to aims 2 and 3 of the parent grant and proposes to examine the influence of (high and low) Human Papilloma Virus (HPV) on the risk of preterm births (PTB) and the possible immune-modulatory role of the vaginal microbiome on such relationship, considering (Black or White) race as a moderator. Aim 1 will estimate the association of HPV with PTB using logistic regression, overall and stratified by high or low risk HPV. We will test race as a moderator for each strata of HPV via an interaction term. Aim 2 will additionally use structural equations modeling to separately estimate the effects of HPV on PTB directly and/or indirectly through the microbiome and inflammation biomarkers. Findings from this study may have significant public health implications for HPV vaccination especially for women who plan to become pregnant. An association with HPV and PTB regardless of subtype may support the need for a broad-spectrum HPV vaccine, inclusive of both, high and low risk subtypes. A differential association between HPV and PTB by race within strata of HPV subtypes may suggest the need for tailored vaccine interventions. Finally understanding the predominant path in the association between HPV and PTB will provide future targets for additional research questions, potentially towards the development of clinical interventions or early diagnostic tools.

摘要：这一多样性补充与父母补助金的目标2和目标3有关，并建议审查 人乳头瘤病毒（HPV）对早产风险的影响（高和低）以及可能的 阴道微生物组在这种关系中的免疫调节作用，考虑到（黑人或白色）种族作为一种 主持人。目的1将使用逻辑回归，总体和分层评估HPV与PTB的相关性 高危或低危HPV我们将通过相互作用项检验种族是否是HPV各分层的调节因素。目的2 此外，还将使用结构方程模型来单独估计HPV对PTB的直接影响 和/或间接通过微生物组和炎症生物标志物。这项研究的结果可能 HPV疫苗接种对公共卫生的重大影响，特别是对计划成为 怀孕了与HPV和PTB的关联，无论亚型如何，都可能支持广谱免疫的需要。 HPV疫苗，包括高风险和低风险亚型。HPV和PTB之间的差异性关联， HPV亚型层内的种族可能表明需要量身定制的疫苗干预措施。终于明白 HPV和PTB之间的主要关联途径将为未来的进一步研究提供目标 这些问题可能有助于开发临床干预措施或早期诊断工具。