The Influence of HPV on Preterm Birth via Immunomodulation of the Microbiome

HPV 通过微生物组免疫调节对早产的影响

• 批准号: 10264412
• 负责人: Gregory Allen Buck
• 金额: $ 22.11万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10264412
• 关键词: Address; Adult; Affect; Allografting; Anaerobic Bacteria; Asians; Bacterial Vaginosis; Biological Markers; Birth; Birth Rate; Categories; Caucasians; Cellular Immunity; Childhood; DNA Viruses; Diagnostic; Disease; Elements; Epidemiology; Equation; Ethnic group; Etiology; Female; Future; Grant; Growth; Hispanics; Human Papilloma Virus Vaccination; Human Papilloma Virus Vaccine; Human Papillomavirus; Human papilloma virus infection; Immune; Infection; Infectious Agent; Inflammation; Inflammatory; Interleukin-1 alpha; Interleukin-10; Interleukin-6; Intervention; Light; Literature; Logistic Regressions; Low risk HPV; Malignant - descriptor; Mediating; Microbe; Microbiology; Modeling; Morbidity - disease rate; Not Hispanic or Latino; Outcome; Parents; Pregnancy; Premature Birth; Prevalence; Progesterone; Public Health; Race; Reporting; Research; Research Personnel; Risk; Role; Sexually Transmitted Diseases; Structure; Testing; Training; United States; Vaccines; Vagina; Woman; Work; adverse pregnancy outcome; bacteriome; black women; clinical development; clinically significant; cytokine; fetal; health disparity; high risk; immunoregulation; microbial; microbiome; neonatal death; parent grant; pathogenic virus; platelet-derived growth factor BB; pregnant; premalignant; programs; reproductive tract; tool; vaginal microbiome; virome

Summary: This diversity supplement relates to aims 2 and 3 of the parent grant and proposes to examine the influence of (high and low) Human Papilloma Virus (HPV) on the risk of preterm births (PTB) and the possible immune-modulatory role of the vaginal microbiome on such relationship, considering (Black or White) race as a moderator. Aim 1 will estimate the association of HPV with PTB using logistic regression, overall and stratified by high or low risk HPV. We will test race as a moderator for each strata of HPV via an interaction term. Aim 2 will additionally use structural equations modeling to separately estimate the effects of HPV on PTB directly and/or indirectly through the microbiome and inflammation biomarkers. Findings from this study may have significant public health implications for HPV vaccination especially for women who plan to become pregnant. An association with HPV and PTB regardless of subtype may support the need for a broad-spectrum HPV vaccine, inclusive of both, high and low risk subtypes. A differential association between HPV and PTB by race within strata of HPV subtypes may suggest the need for tailored vaccine interventions. Finally understanding the predominant path in the association between HPV and PTB will provide future targets for additional research questions, potentially towards the development of clinical interventions or early diagnostic tools.

摘要：该多样性补充与母基金的目标 2 和 3 相关，并建议审查 （高和低）人乳头瘤病毒 (HPV) 对早产 (PTB) 风险的影响以及可能的 阴道微生物组对这种关系的免疫调节作用，将（黑人或白人）种族视为 主持人。目标 1 将使用总体和分层逻辑回归估计 HPV 与 PTB 的关联 由高危或低危 HPV 感染。我们将通过交互项来测试种族作为 HPV 各层的调节因素。目标2 将另外使用结构方程模型直接单独估计 HPV 对 PTB 的影响 和/或间接通过微生物组和炎症生物标志物。这项研究的结果可能有 HPV 疫苗接种对公共卫生产生重大影响，特别是对于计划成为女性的女性 孕。无论亚型如何，与 HPV 和 PTB 的关联可能支持对广谱药物的需求 HPV 疫苗，包括高风险和低风险亚型。 HPV 和 PTB 之间的差异关联 HPV 亚型阶层内的种族可能表明需要量身定制的疫苗干预措施。终于明白了 HPV 和 PTB 之间关联的主要路径将为进一步研究提供未来目标 问题，可能有助于临床干预或早期诊断工具的开发。