A pocket-sized device for personal exposure level assessment

用于个人暴露水平评估的袖珍设备

• 批准号: 8658433
• 负责人: Erica Silvia Forzani
• 金额: $ 49.31万
• 依托单位: TF SENSORS, LLC
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-24 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8658433
• 关键词: Address; Air; Air Pollutants; Benzene; Binding; Breathing; Calibration; Carcinogens; Cells; Cellular Phone; Chemical Exposure; Chemicals; Collaborations; Communication; Communities; Computer software; Cosmetics; Coupled; Data; Detection; Development; Devices; Digital Signal Processing; Disease; Ensure; Environment; Environmental Exposure; Environmental Health; Environmental Monitoring; Epidemiologist; Equipment; Feedback; Future; Gas Chromatography; Genetic Predisposition to Disease; Goals; Gold; Health Technology; Healthcare; Home environment; Household; Housing; Hybrids; Immune; Individual; Industrial Waste; Industry; Location; Mass Spectrum Analysis; Measures; Mechanics; Methods; Molecular; Monitor; Neighborhoods; Neuraxis; Occupational Safety; Performance; Phase; Polymers; Population Study; Prevention; Production; Protocols documentation; Quartz; Reference Standards; Reporting; Research; Resolution; Sampling; Scheme; Scientist; Specificity; Staging; System; Technology; Telephone; Test Result; Testing; Time; Toluene; Toxic Environmental Substances; Universities; Variant; Wireless Technology; Work; Xylene; abstracting; air sampling; base; commercialization; computerized data processing; cost; empowered; ethylbenzene; imprint; improved; innovation; miniaturize; new technology; novel; operation; prototype; remediation; sample collection; sensor; tool; toxicant; trafficking; transmission process; usability; user-friendly; volatile organic compound

DESCRIPTION (provided by applicant): A pocket-sized device for personal exposure level assessment! Abstract Detecting environmental toxicants is critical for better understanding of the relationship between chemical exposures and many diseases, and for more effective prevention of the related diseases. Due to large variations in the individuals' genetic susceptibility and environmental exposure level, an ideal detection tool must be miniaturized, affordable and personalized so that it can measure the toxicants in real time and within each individual's breathing zone. Except for a few selected analytes, the current approach is to collect air samples at a certain location and time, and transport the samples to a lab for detailed analysis using sophisticated but expensive and difficult-to-operate equipment, such as gas chromatography coupled with mass spectrometry. The goal of the present project is to address the above need by introducing a new sensor technology, focusing on harmful analytes, such as carcinogens, which are important but currently not covered by any of the existing portable devices. The sensor technology is based on an innovative hybrid principle that combines intelligent sampling and separation mechanisms with a sensitive microfabricated quartz tuning fork array and selective molecular imprinted polymer sensing materials to achieve high specificity and high sensitivity with a miniaturized device. The device is pocket-sized and contains a Bluetooth chip that communicates wirelessly with cell phones or other Bluetooth-enabled devices. The new technology will provide unprecedented high temporal and high spatial resolutions for personal environmental exposure monitoring, which will benefit a large environmental health research community, support ongoing and future large-scale population studies, and impact on industrial and occupational safety and environmental monitoring. The team will develop, build and test the device in phase I. They will validate it with established collaborations, including epidemiologists, industry hygienists, occupational safety professionals and environmental scientists, and prepare for production of the device in phase II.

描述（由申请人提供）：用于个人暴露水平评估的口袋大小的设备！环境毒物检测对于更好地了解化学品暴露与多种疾病之间的关系，以及更有效地预防相关疾病至关重要。由于个体遗传易感性和环境暴露水平的巨大差异，理想的检测工具必须小型化、可负担和个性化，以便能够实时测量每个人呼吸区域内的有毒物质。除了少数选定的分析物外，目前的方法是收集