Wireless capnograph for respiratory function diagnosis and management

描述(申请人提供)：慢性阻塞性肺病(COPD)和哮喘等慢性呼吸系统疾病影响着3000多万美国人，花费超过300亿美元，在美国排名第四。这些患者中的许多人依赖长期氧疗，这是唯一经过临床证明的非手术疗法，可以治疗他们的肺功能障碍，延长他们的生命。有效的氧疗需要实时二氧化碳分压图，这是一种广泛使用的方法，可以在出现有害的相关症状之前就发现肺功能缺陷，如气体交换不良、呼吸状况异常和肺血流不足。现有的碳酸氢图设备不仅昂贵笨重，而且需要大量培训才能正确操作和维护。本项目的目标是开发一种低成本的无线二氧化碳记录仪，用于个人、家庭氧疗或资源匮乏的紧急护理条件。该设备利用了一种高度选择性和防潮的二氧化碳纳米复合传感材料，这使得能够实时地逐一检测二氧化碳。它使用了一种新的集成样品收集和检测原理，并与智能信号处理算法协同结合，以最大限度地提高分析精度。该技术具有结构紧凑、成本低、用户友好、健壮性强等特点。此外，该设备可以无线配对到用户的手机、电脑、笔记本电脑、上网本或小报上，在患者和医疗保健专业人员之间提供一个无缝的信息门户，并最大限度地为庞大和不断增长的慢性呼吸道疾病患者带来好处。PIS在开发和验证用于个人疾病诊断和管理的无线化学传感器方面拥有丰富的经验。他们将与疗养院的医生和护士密切合作，开发这项创新技术，并将其转变为高性能移动设备，以满足大量慢性呼吸道疾病患者的未得到满足的需求。

DESCRIPTION (provided by applicant): Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma, affect more than 30 million Americans, cost over 30 billion dollars, and rank as the fourth death cause in the U.S. Many of these patients rely on long-term oxygen therapy, the only clinically proven and non-surgical therapy to treat their pulmonary dysfunctions and to extend their lives. Effective oxygen therapy requires real-time capnography, a widely used method that can detect deficiency of pulmonary functions, such as poor gas exchange, abnormal ventilation conditions, and insufficient lung blood flow even before detrimental associated symptoms. The existing capnography equipment not only is expensive and bulky, but also requires substantial training for correct operation and maintenance. The goal of the present project is to develop a low cost and wireless capnography device for personal, home-based oxygen therapy or for resource deprived emergency care conditions. The device takes advantage of a highly selective and humidity immune nanocomposite sensing material for carbon dioxide, which enables real-time breath-by-breath carbon dioxide detection. It uses a novel integrated sample collection and detection principle synergistically combined with an intelligent signal- processing algorithm to maximize analysis accuracy. The technology features compactness, low cost, user friendliness, and robustness. In addition, the device can be wirelessly paired to the user cell-phone, computer, notebook, netbook or tabloid, providing a seamless information gateway between patients and medical care professionals and maximizing its benefit to the large and growing chronic respiratory disease patients. The PIs have substantial experience in developing and validating wireless chemical sensors for personal disease diagnosis and management. They will work closely with physicians and nurses in nursing homes to develop the innovative technology and transform it into a high performance mobile device to address the unmet needs of the large chronic respiratory disease patient population.