Wireless capnograph for respiratory function diagnosis and management

描述（由申请人提供）：慢性呼吸道疾病，如慢性阻塞性肺病（COPD）和哮喘，影响超过3000万美国人，花费超过300亿美元，并在美国排名第四。这些患者中的许多人依赖于长期氧疗，这是唯一经临床证实的非手术疗法来治疗他们的肺功能障碍并延长他们的生命。有效的氧疗需要实时二氧化碳描记术，这是一种广泛使用的方法，可以检测肺功能的缺陷，例如气体交换不良，异常通气条件和肺血流量不足，甚至在有害的相关症状之前。现有的二氧化碳描记设备不仅昂贵且体积庞大，而且需要大量的培训以进行正确的操作和维护。本项目的目标是开发一种低成本的无线二氧化碳监测设备，用于个人、家庭氧疗或资源匮乏的紧急护理条件。该设备利用了一种高选择性和抗湿度的纳米复合二氧化碳传感材料，可实现实时呼吸二氧化碳检测。它采用了一种新的集成样品收集和检测原理，协同结合智能信号处理算法，以最大限度地提高分析精度。该技术具有紧凑、低成本、用户友好和鲁棒性的特点。此外，该设备可以无线配对到用户手机，计算机，笔记本电脑，上网本或小报，提供患者和医疗保健专业人员之间的无缝信息网关，并最大限度地提高其对大型和不断增长的慢性呼吸道疾病患者的益处。PI在开发和验证用于个人疾病诊断和管理的无线化学传感器方面具有丰富的经验。他们将与疗养院的医生和护士密切合作，开发创新技术，并将其转化为高性能的移动终端，以满足大量慢性呼吸道疾病患者群体未得到满足的需求。

DESCRIPTION (provided by applicant): Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma, affect more than 30 million Americans, cost over 30 billion dollars, and rank as the fourth death cause in the U.S. Many of these patients rely on long-term oxygen therapy, the only clinically proven and non-surgical therapy to treat their pulmonary dysfunctions and to extend their lives. Effective oxygen therapy requires real-time capnography, a widely used method that can detect deficiency of pulmonary functions, such as poor gas exchange, abnormal ventilation conditions, and insufficient lung blood flow even before detrimental associated symptoms. The existing capnography equipment not only is expensive and bulky, but also requires substantial training for correct operation and maintenance. The goal of the present project is to develop a low cost and wireless capnography device for personal, home-based oxygen therapy or for resource deprived emergency care conditions. The device takes advantage of a highly selective and humidity immune nanocomposite sensing material for carbon dioxide, which enables real-time breath-by-breath carbon dioxide detection. It uses a novel integrated sample collection and detection principle synergistically combined with an intelligent signal- processing algorithm to maximize analysis accuracy. The technology features compactness, low cost, user friendliness, and robustness. In addition, the device can be wirelessly paired to the user cell-phone, computer, notebook, netbook or tabloid, providing a seamless information gateway between patients and medical care professionals and maximizing its benefit to the large and growing chronic respiratory disease patients. The PIs have substantial experience in developing and validating wireless chemical sensors for personal disease diagnosis and management. They will work closely with physicians and nurses in nursing homes to develop the innovative technology and transform it into a high performance mobile device to address the unmet needs of the large chronic respiratory disease patient population.