Wireless capnograph for respiratory function diagnosis and management

用于呼吸功能诊断和管理的无线二氧化碳描记器

• 批准号: 8212706
• 负责人: Erica Silvia Forzani
• 金额: $ 17.77万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8212706
• 关键词: Address; Affect; Air; Algorithms; American; Arizona; Asthma; Blood flow; Breathing; Calibration; Capnography; Carbon Dioxide; Cardiovascular system; Caring; Cause of Death; Cellular Phone; Chemicals; Chest; Chronic; Chronic Obstructive Airway Disease; Code; Collaborations; Communication; Computer software; Computers; Data; Data Display; Detection; Devices; Diagnosis; Disease Management; Emergency Care; Ensure; Environmental air flow; Equipment; Exhalation; Functional disorder; Future; Gases; Glosso-Sterandryl; Goals; Health Professional; Home environment; Humidity; Immune; Immunity; Independent Living; Lung; Lung diseases; Maintenance; Measurement; Medical; Medical center; Methods; Monitor; Nurses; Nursing Homes; Oxygen Therapy Care; Patients; Pattern; Performance; Physicians; Pilot Projects; Population; Process; Reaction Time; Reporting; Reproducibility; Resistance; Resources; Respiration; Respiratory physiology; Signal Transduction; Societies; Symptoms; System; Technology; Telephone; Testing; Thioguanine; Time; Tissues; Training; Universities; Validation; Wireless Technology; Work; aged; base; computerized data processing; cost; cost effective; data acquisition; design; disease diagnosis; experience; innovation; innovative technologies; laptop; meetings; nanocomposite; novel; operation; patient population; prototype; pulmonary function; research study; respiratory; response; sample collection; sensor; transmission process; usability

DESCRIPTION (provided by applicant): Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma, affect more than 30 million Americans, cost over 30 billion dollars, and rank as the fourth death cause in the U.S. Many of these patients rely on long-term oxygen therapy, the only clinically proven and non-surgical therapy to treat their pulmonary dysfunctions and to extend their lives. Effective oxygen therapy requires real-time capnography, a widely used method that can detect deficiency of pulmonary functions, such as poor gas exchange, abnormal ventilation conditions, and insufficient lung blood flow even before detrimental associated symptoms. The existing capnography equipment not only is expensive and bulky, but also requires substantial training for correct operation and maintenance. The goal of the present project is to develop a low cost and wireless capnography device for personal, home-based oxygen therapy or for resource deprived emergency care conditions. The device takes advantage of a highly selective and humidity immune nanocomposite sensing material for carbon dioxide, which enables real-time breath-by-breath carbon dioxide detection. It uses a novel integrated sample collection and detection principle synergistically combined with an intelligent signal- processing algorithm to maximize analysis accuracy. The technology features compactness, low cost, user friendliness, and robustness. In addition, the device can be wirelessly paired to the user cell-phone, computer, notebook, netbook or tabloid, providing a seamless information gateway between patients and medical care professionals and maximizing its benefit to the large and growing chronic respiratory disease patients. The PIs have substantial experience in developing and validating wireless chemical sensors for personal disease diagnosis and management. They will work closely with physicians and nurses in nursing homes to develop the innovative technology and transform it into a high performance mobile device to address the unmet needs of the large chronic respiratory disease patient population. PUBLIC HEALTH RELEVANCE: A non-invasive, integrated wireless sensing device for capnography will be developed. This device enables real-time assessment of pulmonary functions of patients with chronic breathing dysfunctions, provide efficient and cost effective patient management, and contribute to healthy and independent living of aged population.

描述（由申请人提供）：慢性呼吸道疾病，如慢性阻塞性肺病 (COPD) 和哮喘，影响着超过 3000 万美国人，花费超过 300 亿美元，是美国第四大死因。其中许多患者依赖长期氧疗，这是唯一经过临床证明的非手术疗法来治疗肺功能障碍并延长生命。有效的氧疗需要实时二氧化碳图，这是一种广泛使用的方法，可以在出现有害的相关症状之前检测肺功能缺陷，例如气体交换不良、通气条件异常和肺血流量不足。现有的二氧化碳图设备不仅昂贵且体积庞大，而且需要大量培训才能正确操作和维护。本项目的目标是开发一种低成本无线二氧化碳图设备，用于个人家庭氧疗或资源匮乏的紧急护理情况。该设备利用了二氧化碳的高选择性和湿度免疫纳米复合传感材料，可以实时检测每次呼吸的二氧化碳。它采用新颖的集成样品采集和检测原理，与智能信号处理算法协同结合，以最大限度地提高分析精度。该技术具有结构紧凑、成本低、用户友好和鲁棒性等特点。此外，该设备还可以与用户的手机、电脑、笔记本电脑、上网本或小报无线配对，为患者和医疗保健专业人员之间提供无缝信息网关，并最大限度地造福于数量庞大且不断增长的慢性呼吸道疾病患者。 PI 在开发和验证用于个人疾病诊断和管理的无线化学传感器方面拥有丰富的经验。他们将与疗养院的医生和护士密切合作，开发创新技术并将其转化为高性能移动设备，以满足大量慢性呼吸道疾病患者未得到满足的需求。 公共健康相关性：将开发一种用于二氧化碳图的非侵入式集成无线传感设备。该设备能够实时评估慢性呼吸功能障碍患者的肺功能，提供高效且具有成本效益的患者管理，并有助于老年人群的健康和独立生活。