Wireless capnograph for respiratory function diagnosis and management

用于呼吸功能诊断和管理的无线二氧化碳描记器

• 批准号: 8212706
• 负责人: Erica Silvia Forzani
• 金额: $ 17.77万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8212706
• 关键词: Address; Affect; Air; Algorithms; American; Arizona; Asthma; Blood flow; Breathing; Calibration; Capnography; Carbon Dioxide; Cardiovascular system; Caring; Cause of Death; Cellular Phone; Chemicals; Chest; Chronic; Chronic Obstructive Airway Disease; Code; Collaborations; Communication; Computer software; Computers; Data; Data Display; Detection; Devices; Diagnosis; Disease Management; Emergency Care; Ensure; Environmental air flow; Equipment; Exhalation; Functional disorder; Future; Gases; Glosso-Sterandryl; Goals; Health Professional; Home environment; Humidity; Immune; Immunity; Independent Living; Lung; Lung diseases; Maintenance; Measurement; Medical; Medical center; Methods; Monitor; Nurses; Nursing Homes; Oxygen Therapy Care; Patients; Pattern; Performance; Physicians; Pilot Projects; Population; Process; Reaction Time; Reporting; Reproducibility; Resistance; Resources; Respiration; Respiratory physiology; Signal Transduction; Societies; Symptoms; System; Technology; Telephone; Testing; Thioguanine; Time; Tissues; Training; Universities; Validation; Wireless Technology; Work; aged; base; computerized data processing; cost; cost effective; data acquisition; design; disease diagnosis; experience; innovation; innovative technologies; laptop; meetings; nanocomposite; novel; operation; patient population; prototype; pulmonary function; research study; respiratory; response; sample collection; sensor; transmission process; usability

DESCRIPTION (provided by applicant): Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma, affect more than 30 million Americans, cost over 30 billion dollars, and rank as the fourth death cause in the U.S. Many of these patients rely on long-term oxygen therapy, the only clinically proven and non-surgical therapy to treat their pulmonary dysfunctions and to extend their lives. Effective oxygen therapy requires real-time capnography, a widely used method that can detect deficiency of pulmonary functions, such as poor gas exchange, abnormal ventilation conditions, and insufficient lung blood flow even before detrimental associated symptoms. The existing capnography equipment not only is expensive and bulky, but also requires substantial training for correct operation and maintenance. The goal of the present project is to develop a low cost and wireless capnography device for personal, home-based oxygen therapy or for resource deprived emergency care conditions. The device takes advantage of a highly selective and humidity immune nanocomposite sensing material for carbon dioxide, which enables real-time breath-by-breath carbon dioxide detection. It uses a novel integrated sample collection and detection principle synergistically combined with an intelligent signal- processing algorithm to maximize analysis accuracy. The technology features compactness, low cost, user friendliness, and robustness. In addition, the device can be wirelessly paired to the user cell-phone, computer, notebook, netbook or tabloid, providing a seamless information gateway between patients and medical care professionals and maximizing its benefit to the large and growing chronic respiratory disease patients. The PIs have substantial experience in developing and validating wireless chemical sensors for personal disease diagnosis and management. They will work closely with physicians and nurses in nursing homes to develop the innovative technology and transform it into a high performance mobile device to address the unmet needs of the large chronic respiratory disease patient population. PUBLIC HEALTH RELEVANCE: A non-invasive, integrated wireless sensing device for capnography will be developed. This device enables real-time assessment of pulmonary functions of patients with chronic breathing dysfunctions, provide efficient and cost effective patient management, and contribute to healthy and independent living of aged population.

描述（由申请人提供）：慢性呼吸系统疾病，如慢性阻塞性肺疾病（COPD）和哮喘，影响了超过3000万美国人，花费超过300亿美元，是美国第四大死亡原因。这些患者中的许多人依赖长期氧疗，这是唯一临床证明的非手术治疗肺功能障碍和延长生命的方法。有效的氧气治疗需要实时肺泡造影，这是一种广泛使用的方法，可以在有害的相关症状出现之前发现肺功能缺陷，如气体交换不良、异常通气条件和肺血流量不足。现有的血管造影设备不仅价格昂贵，体积庞大，而且需要大量的培训才能正确操作和维护。本项目的目标是开发一种低成本的无线血管造影设备，用于个人、家庭氧气治疗或资源匮乏的紧急护理条件。该装置利用了一种高度选择性和湿度免疫的二氧化碳纳米复合传感材料，可以实现实时的呼吸二氧化碳检测。它采用了一种新颖的集成样品采集和检测原理，与智能信号处理算法协同结合，以最大限度地提高分析精度。该技术具有紧凑、低成本、用户友好和健壮性等特点。此外，该设备可以与用户的手机、电脑、笔记本、上网本或小报进行无线配对，为患者和医疗专业人员提供无缝的信息网关，最大限度地为数量庞大且不断增长的慢性呼吸系统疾病患者提供服务。pi在开发和验证用于个人疾病诊断和管理的无线化学传感器方面具有丰富的经验。他们将与养老院的医生和护士密切合作，开发创新技术，并将其转化为高性能移动设备，以解决大量慢性呼吸系统疾病患者的未满足需求。