Mobile multifunctional tool for monitoring and management of respiratory diseases

用于监测和管理呼吸系统疾病的移动多功能工具

• 批准号: 9041019
• 负责人: Erica Silvia Forzani
• 金额: $ 47.46万
• 依托单位: TF HEALTH CORPORATION
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-16 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9041019
• 关键词: Acoustics; Affect; Algorithms; American; Asthma; Back; Breath Tests; Businesses; Capnography; Carbon Dioxide; Cellular Phone; Certification; Chest; Chronic; Chronic Obstructive Airway Disease; Clinical; Clinics and Hospitals; Communication; Computer software; Current Procedural Terminology Codes; Data Display; Data Storage and Retrieval; Detection; Device or Instrument Development; Devices; Diagnosis; Discrimination; Disease; Electromagnetics; Equipment; Gases; Goals; Guidelines; Health; Health Status; Health Technology; Hospitals; Humidity; Immune; Industry; Insurance; Life; Light; Lighting; Lung diseases; Marketing; Measurement; Measures; Medical; Medical Device; Medical center; Monitor; Patient Monitoring; Patients; Performance; Phase; Population; Production; Protocols documentation; Quality Control; Reaction Time; Receiver Operating Characteristics; Risk Assessment; Safety; Sales; Sampling; Sensitivity and Specificity; Societies; Spirometry; Supervision; Technology; Temperature; Test Result; Testing; Wireless Technology; Work; asthmatic patient; consumer product; cost; design; effective therapy; handheld mobile device; innovation; instrument; mHealth; meetings; nanocomposite; pressure; pulmonary function; quality assurance; sensor; signal processing; success; tool; usability; user-friendly; verification and validation

 DESCRIPTION (provided by applicant): Mobile multifunctional tool for monitoring and management of respiratory diseases Chronic Obstructive Pulmonary Disease (COPD) and asthma affect millions of people worldwide. Because there is no permanent cure for these diseases, efficient management of the patients is needed. New mobile health technologies, such as personal devices that allow patients to monitor their diseases under or near free- living conditions, will lower the cost, and thus contribute to the solution of the problem. Furthermore, continuous monitoring of the patients' health status afforded by the mobile devices will provide more complete information than the sporadic medical exams carried out currently in hospital or clinical settings. The most effective diagnosis and management technologies for COPD and asthma are spirometry and capnography. However, traditional low-cost spirometers are relatively inaccurate and lack of gas exchange information, and the capnography equipment is bulky, expensive, and difficult-to-operate without close supervision of professionals. These factors have limited spirometry and capnography to the use in hospital or clinic setting only. The present project aims at developing a personal device that can perform both capnography and spirometry for patients to use outside of hospitals and clinics. Creating such a device has been a challenge. To overcome the challenge, the Phase 1 part of the project has successfully developed and validated several innovations, including 1) a nanocomposite sensing material for accurate breath-by- breath analysis of carbon dioxide concentrations, 2) a low cost and high performance acoustic flow sensor that covers a wide dynamic range for both low flow-rate capnography and high flow-rate spirometry, 3) an adaptive sampling algorithm for correctly collecting the patient's breath without the presence of professionals, and 4) a cell phone application for signal processing. Building upon the success of Phase 1, this Phase 2 project will transform the technology into a real world solution for COPD and asthma patients by designing, building and testing a complete device with cell phone App, establishing manufacturing protocols, and preparing a FDA application. The project will bring together strengths of the sensor development and device fabrication at TF Health Co (doing business as Breezing Co.), sensor characterization and testing team at ASU, and clinical expertise of Banner Good Samaritan Medical Center to achieve the goal. The team has worked together and completed all the milestones in Phase 1, and is ready to overcome technical challenges and to develop the first wireless device with both spirometry and capnography capabilities.

 描述（由适用提供）：用于监测和管理呼吸道疾病的移动多功能工具慢性阻塞性肺部疾病（COPD）和哮喘影响着全球数百万的人。由于这些疾病没有永久治愈，因此需要对患者进行有效的治疗。新的移动健康技术，例如允许患者在自由生活条件下或接近自由生活条件下监测其疾病的个人设备，将降低成本，从而有助于解决问题。此外，与目前在医院或临床环境中进行的螺旋体医学检查相比，移动设备提供的患者健康状况的持续监测将提供更多的完整信息。 COPD和哮喘的最有效的诊断和管理技术是肺活量测定法和capnography。但是，传统的低成本肺活量计相对不准确且缺乏天然气交换信息，而没有专业人员的密切监督，串联设备笨重，昂贵且难以运行。这些因素仅在医院或诊所环境中使用的思目和ca摄影术有限。本项目旨在开发一种个人设备，该设备可以同时执行综合术和精神法，以供患者在医院和诊所外使用。创建这样的设备一直是一个挑战。为了克服挑战，该项目的第一阶段部分已成功开发和验证了几项创新，包括1）纳米复合材料传感器材料，以准确呼吸二氧化碳浓度，2）低成本和高性能的声流传感器，可覆盖低流量循环和高流量式的动态范围，以覆盖较低的动态范围，以使其及时及格流动式效果，3）呼吸没有专业人员的存在，以及4）手机使用信号处理。在第1阶段成功的基础上，该第2阶段项目将通过设计，建立和测试使用手机应用程序，建立制造协议并准备FDA应用程序的完整设备，将技术转变为COPD和哮喘患者的现实解决方案。该项目将汇集TF Health Co（以微风公司开展业务），ASU的传感器表征和测试团队以及Banner Good Samaritan Medical Center的临床专业知识以实现目标的临床专业知识，以实现目标。该团队共同努力并完成了第1阶段的所有里程碑，并准备克服技术挑战并开发具有肺活量测定和CAPNography功能的第一个无线设备。