Continuation: UMMC's Clinical Center in NIDDK's Gastroparesis Research

续：UMMC NIDDK 胃轻瘫研究临床中心

• 批准号: 8730616
• 负责人: Thomas Lyman Abell
• 金额: $ 31.47万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-15 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8730616
• 关键词: Area; Automation; Biometry; Biopsy Specimen; Clinical; Clinical Research; Complex; Data; Data Analyses; Diagnosis; Disease; Doctor of Philosophy; Electric Stimulation; Electrophysiology (science); Enrollment; Etiology; Funding; Gastric Emptying; Gastric Tissue; Gastroparesis; Head; Health; Hormonal; Individual; Interstitial Cell of Cajal; Measures; Medical center; Mississippi; Operative Surgical Procedures; Pathology; Pathway interactions; Patients; Population Study; Positioning Attribute; Protocols documentation; Registries; Research; Research Personnel; Resources; Signal Transduction; Site; Specimen; Stomach; Symptoms; Time; Universities; diabetic; experience; instrumentation; member; multidisciplinary; young woman

DESCRIPTION (provided by applicant): The University of Mississippi Medical Center proposes to continue its participation as a Clinical Center in NIDDK's Gastroparesis Clinical Research Consortium. Our study team, headed by Thomas Abell, MD, a recognized expert in research and clinical experience in the area of gastroparesis, will now include as co- investigator Michael Griswold, PhD, an expert in biostatistics, and as collaborator Filip To, PhD, an expert in data automation, signal analysis, data fusion, and instrumentation, along with key members of our initial research team and two UMC collaborators from Surgery and Pathology, respectively. The multidisciplinary expertise provided by this team will further our ability to investigate the complex pathophysiological pathways and symptoms associated with gastroparesis. The UMMC Vice Chancellor for Health Affairs and the Associate Vice Chancellor for Research continue to provide strong support for and the resources necessary to conducting the Clinical Center's research. With respect to Consortium-wide contributions, UMMC is well positioned to increase the study population already enrolled in the Gastroparesis Registry through its Clinical Center. Approximately 1000 patients with gastroparesis annually seek their treatment at this site; over the past 5 years, we have evaluated new patients for the disorder, identifying on the average 300 new patients with gastroparesis each year. In addition to furthering Consortium-wide protocols, two new-efforts have been proposed for the present funding period at UMMC. The first is to assess and compare associations between presenting Gl symptoms, histological counts of interstitial cells of Cajal, and electrophysiology measures for patients with GP of diabetic and idiopathic etiology, as well as to compare ICC counts in these biopsy specimens with counts in gastric tissue specimens from controls. The second is to demonstrate that Gastric Electrical Stimulation (GES) can reduce Gl symptoms by at least 50% for individual patients, to assess the impact of temporary GES on gastric emptying times, EGG values, neuro-hormonal and autonomic status markers, and HRQOL measures, and to evaluate EGG values at varied GES energy levels in predicting likely usefulness with GES.

描述（由申请人提供）：密西西比大学医学中心提议继续作为临床中心参与 NIDDK 胃轻瘫临床研究联盟。我们的研究团队由胃轻瘫领域公认的研究和临床经验专家 Thomas Abell 医学博士领导，现在将包括生物统计学专家 Michael Griswold 博士作为联合研究员，数据自动化、信号分析、数据融合和仪器方面的专家 Filip To 博士作为合作者，以及我们最初研究团队的主要成员以及分别来自外科和病理学的两名 UMC 合作者。该团队提供的多学科专业知识将进一步提高我们研究与胃轻瘫相关的复杂病理生理学途径和症状的能力。 UMMC 负责健康事务的副校长和负责研究的副校长继续为临床中心的研究提供强有力的支持和必要的资源。 就联盟范围内的贡献而言，UMMC 处于有利地位，可以通过其临床中心增加已在胃轻瘫登记处登记的研究人数。每年约有 1000 名胃轻瘫患者在此寻求治疗；在过去 5 年里，我们对新患者进行了胃轻瘫评估，平均每年发现 300 名新患者患有胃轻瘫。除了推进联盟范围内的协议外，UMMC 还在当前资助期内提出了两项​​新的努力。第一个是评估和比较糖尿病和特发性病因的 GP 患者呈现的胃肠道症状、Cajal 间质细胞的组织学计数和电生理学测量之间的关联，以及将这些活检标本中的 ICC 计数与来自对照的胃组织标本中的计数进行比较。第二个目的是证明胃电刺激 (GES) 可以使个体患者的胃肠道症状减轻至少 50%，评估临时 GES 对胃排空时间、EGG 值、神经激素和自主状态标记以及 HRQOL 测量的影响，并评估不同 GES 能量水平下的 EGG 值，以预测 GES 的可能有用性。