Continuation: UMMC's Clinical Center in NIDDK's Gastroparesis Research

描述(由申请人提供)：密西西比大学医学中心建议继续作为NIDDK的胃瘫临床研究联盟的临床中心参与。我们的研究团队由Thomas Abell医学博士领导，他是胃瘫领域公认的研究和临床经验专家，现在将包括生物统计学专家Michael Griswold博士和数据自动化、信号分析、数据融合和仪器专家Filip To博士作为合作者，以及我们最初研究团队的主要成员和UMC分别来自外科和病理学的两名合作者。该团队提供的多学科专业知识将进一步提高我们调查与胃瘫相关的复杂病理生理途径和症状的能力。UMMC负责卫生事务的副校长和负责研究的副校长继续为开展临床中心的研究提供强有力的支持和必要的资源。就整个联盟的贡献而言，UMMC处于有利地位，可以通过其临床中心增加已经在胃轻瘫登记中登记的研究人群。每年大约有1000名胃瘫患者在这个网站寻求治疗；在过去的5年里，我们评估了这种疾病的新患者，平均每年发现300名新的胃瘫患者。除了进一步推进联合体范围的协议外，还为联华大学目前的资金期提出了两项新的努力。第一个是评估和比较糖尿病和特发性病因的GP患者的Gl症状、Cajal间质细胞的组织学计数和电生理指标之间的相关性，以及比较这些活检标本中的ICC计数和来自对照的胃组织标本中的ICC计数。第二个目的是证明胃电刺激(GES)可以减轻个体患者至少50%的GL症状，评估暂时性GES对胃排空时间、胃电刺激的胃电活动、神经激素和自主神经状态标记物以及HRQOL测量的影响，以及评估不同胃电刺激能量水平下的胃电刺激对预测胃电刺激的有效性。

DESCRIPTION (provided by applicant): The University of Mississippi Medical Center proposes to continue its participation as a Clinical Center in NIDDK's Gastroparesis Clinical Research Consortium. Our study team, headed by Thomas Abell, MD, a recognized expert in research and clinical experience in the area of gastroparesis, will now include as co- investigator Michael Griswold, PhD, an expert in biostatistics, and as collaborator Filip To, PhD, an expert in data automation, signal analysis, data fusion, and instrumentation, along with key members of our initial research team and two UMC collaborators from Surgery and Pathology, respectively. The multidisciplinary expertise provided by this team will further our ability to investigate the complex pathophysiological pathways and symptoms associated with gastroparesis. The UMMC Vice Chancellor for Health Affairs and the Associate Vice Chancellor for Research continue to provide strong support for and the resources necessary to conducting the Clinical Center's research. With respect to Consortium-wide contributions, UMMC is well positioned to increase the study population already enrolled in the Gastroparesis Registry through its Clinical Center. Approximately 1000 patients with gastroparesis annually seek their treatment at this site; over the past 5 years, we have evaluated new patients for the disorder, identifying on the average 300 new patients with gastroparesis each year. In addition to furthering Consortium-wide protocols, two new-efforts have been proposed for the present funding period at UMMC. The first is to assess and compare associations between presenting Gl symptoms, histological counts of interstitial cells of Cajal, and electrophysiology measures for patients with GP of diabetic and idiopathic etiology, as well as to compare ICC counts in these biopsy specimens with counts in gastric tissue specimens from controls. The second is to demonstrate that Gastric Electrical Stimulation (GES) can reduce Gl symptoms by at least 50% for individual patients, to assess the impact of temporary GES on gastric emptying times, EGG values, neuro-hormonal and autonomic status markers, and HRQOL measures, and to evaluate EGG values at varied GES energy levels in predicting likely usefulness with GES.