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Animal Models of Suicide Relevant Intermediate Behavioral, Neurobiological and M

自杀相关中级行为、神经生物学和 M 的动物模型

基本信息

批准号：
8917363
负责人：
FRANCES A. CHAMPAGNE
金额：
--
依托单位：
NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-08-01 至 2018-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8917363
关键词：
Adolescent Adrenal Glands Aggressive behavior Amygdaloid structure Animal Model Anxiety Autopsy Behavioral Binding Biological Blood Brain Brain region Brain-Derived Neurotrophic Factor Cells Childhood Clinical Corticosterone Corticotropin-Releasing Hormone Corticotropin-Releasing Hormone Receptors DNA Methylation Development Disease susceptibility Epigenetic Process Exhibits Future Gene Cluster Gene Expression Gene Expression Profile Gene Targeting Genes Glucocorticoid Receptor Hippocampus (Brain)Histone Deacetylase Inhibitor Human Hypothalamic structure Impulsivity Inbreeding Individual Instruction Intervention Knowledge Laboratory mice Life Link Mental Depression Molecular Monoamine Oxidase A Mus Neurobiology Neurons Neurotransmitter Receptor Nucleic Acid Regulatory Sequences Outcome Measure Pathway interactions Peripheral Phenotype Pituitary Gland Promoter Regions Research Risk Risk Factors Stress Suicide Testing Time Tissue-Specific Gene Expression Tissues Tryptophan 5-monooxygenase Variant abuse neglect brain tissue complement system corticotropin releasing factor-binding protein environmental enrichment for laboratory animals environmental intervention epigenetic variation experience glycogen synthase kinase 3 beta human RGS2 protein indexing infancy insight maternal separation molecular phenotype neuroimaging novel strategies postnatal promoter response serotonin 5 receptor serotonin transporter social suicidal behavior suicidal risk

项目摘要

The experience of childhood adversity in the form of neglect/abuse is a major risk factor for future suicidal behavior perhaps via long-term changes in molecular and neurobiological substrates of anxiety, depression, and impulsivity/aggression. The mechanistic links between childhood adversity, molecular/neurobiological pathways, and suicide risk have yet to be established. We propose to investigate key hypotheses regarding: 1) whether childhood adversity is a causal antecedent to suicide behavioral, neurobiological, and molecular phenotypes; 2) the time course of adversity-induced effects on gene expression and epigenetic variation within target gene clusters: 3) the degree of concordance between peripheral cell epigenetic marks and those present in the brain; and 4) explore reversal of such effects by

儿童时期经历的忽视/虐待是未来自杀的主要风险因素行为可能通过焦虑，抑郁，和冲动/攻击性。童年逆境、分子/神经生物学之间的机械联系自杀风险和自杀途径尚未确定。我们建议调查以下方面的关键假设： 1)儿童期逆境是否是自杀行为、神经生物学和分子生物学的因果前因表型; 2）逆境诱导对基因表达和表观遗传变异影响的时间过程在靶基因簇内：3）外周细胞表观遗传标记和存在于大脑中的那些;以及4）探索通过以下方式逆转这种效应：