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Developmental Brain Atlas Tools and Data Applied to Humans and Macaques

应用于人类和猕猴的发育脑图谱工具和数据

基本信息

批准号：
8860552
负责人：
Marc Niethammer
金额：
$ 3.92万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-08 至 2016-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8860552
关键词：
3 year old Accounting Address Adolescent Age Animal Model Animals Appearance Atlases Autistic Disorder Behavioral Birth Brain Characteristics Childhood Cognitive Communities Comparative Study Complex Confidence Intervals Cross-Sectional Studies Data Databases Development Diffusion Diffusion Magnetic Resonance Imaging Disease Documentation Evaluation Female Fiber Gender Generations Grant Health Histocompatibility Testing Human Human Development Image Imaging Device Infant Infection Instruction Internet Lead Life Lobar Longitudinal Studies Macaca Macaca mulatta Magnetic Resonance Imaging Measurement Measures Mental disorders Methodology Methods Modeling Monkeys National Institute of Mental Health Nature Neurodevelopmental Disorder Organism Pathology Pattern Pharmaceutical Preparations Population Positioning Attribute Prevalence Primates Procedures Process Property Published Comment Reporting Research Research Personnel Resources Sampling Schizophrenia Sex Characteristics Slice Social Interaction Source Source Code Staging Statistical Methods Statistical Models Statistical sensitivity Structure Techniques Testing Thick Time Tissues United States National Institutes of Health Variant Weight base brain tissue cognitive function cohort comparative computational atlas computerized tools cost effective data acquisition design early adolescence experience human data infancy innovation insight longitudinal database male method development morphometry neonate neurodevelopment neuroimaging neuropathology nonhuman primate novel operation prenatal relating to nervous system sex tool tool development white matter

项目摘要

DESCRIPTION (provided by applicant): In the last decade, MRI studies of human brain morphometry have been used to investigate a multitude of pathologies and drug-related effects in psychiatric research. Better understanding of normal neural development is essential to gain a better understanding of the underlying pathology of neurodevelopmental disorders such as autism or schizophrenia, as the timing of an insult into the developing brain is often critical in defining the resulting disorder. Nonhuman primates, and in particular macaque monkeys, have been widely used in animal models to investigate the neural substrates of human development in higher cognitive functions and complex social interactions. However, we lack crucial, detailed information of normal brain maturation in macaques, especially in the rapidly changing early stages. Matching maturational periods in humans with those in macaques aids us in establishing nonhuman primate translational models of developmental neuropathology. This project will provide three results: a) a developmental macaque brain MR database, b) the corresponding computational toolbox for cross-sectional and longitudinal atlas building and c) a comparative study contrasting human and macaque brain development and maturation patterns in both genders based on the former. The computational atlas building toolbox will be of translational nature as it is applied to the existing human NIH MRI database of normal brain development, as well as the proposed macaque brain development database. This longitudinal database will be acquired from a cohort of healthy macaque monkeys ranging from a few week olds up to 3-year-old adolescents. This grant is thus translational from a viewpoint of both the study of brain development as well as method and tool development. This creates an immensely valuable resource for primate researcher, as well as for the general neuroimaging field. The comparative study will allow us to characterize normal brain development in the rhesus macaque and compare it to human brain development. We expect that the efficient and cost-effective creation and dissemination of this unique database, the computational toolbox, along with the results from the developmental study will lead to the creation of many new translational primate models of developmental neuropathology worldwide.

描述（由申请人提供）：在过去的十年中，人脑形态测量的 MRI 研究已被用于调查精神病学研究中的多种病理学和药物相关效应。更好地了解正常神经发育对于更好地了解自闭症或精神分裂症等神经发育障碍的潜在病理学至关重要，因为发育中的大脑受到损伤的时间通常对于定义由此产生的障碍至关重要。非人类灵长类动物，特别是猕猴，已被广泛用于动物模型中，以研究人类在高级认知功能和复杂社会互动方面发展的神经基础。然而，我们缺乏猕猴正常大脑成熟的关键、详细信息，特别是在快速变化的早期阶段。将人类的成熟期与猕猴的成熟期相匹配有助于我们建立发育神经病理学的非人类灵长类动物转化模型。该项目将提供三个结果：a）发育猕猴大脑MR数据库，b）用于横截面和纵向图谱构建的相应计算工具箱，以及c）基于前者对比人类和猕猴两性大脑发育和成熟模式的比较研究。计算图谱构建工具箱将具有转化性质，因为它适用于现有的人类 NIH MRI 正常大脑发育数据库，以及拟议的猕猴大脑发育数据库。该纵向数据库将从一组健康的猕猴中获得，这些猕猴的范围从几周大到 3 岁的青少年。因此，从大脑发育研究以及方法和工具开发的角度来看，这笔资助具有转化意义。这为灵长类研究人员以及一般神经影像领域创造了极其宝贵的资源。这项比较研究将使我们能够表征恒河猴的正常大脑发育，并将其与人类大脑发育进行比较。我们期望，这个独特的数据库、计算工具箱的高效且具有成本效益的创建和传播，以及发育研究的结果将导致在全球范围内创建许多新的发育神经病理学转化灵长类动物模型。