Interventional and Feeding Studies of Alcohol

酒精的干预和喂养研究

• 批准号: 8785821
• 负责人: KENNETH Jay MUKAMAL
• 金额: $ 6.15万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-02-15 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8785821
• 关键词: Affect; Alcohol abuse; Alcohol consumption; Alcohols; Animals; Area; Atherosclerosis; Benefits and Risks; Biological; Biological Markers; Breast; Cardiovascular system; Cholelithiasis; Chronic Disease; Clinical Trials; Complex; Congestive Heart Failure; Coronary heart disease; Data; Diabetes Mellitus; Dietary Intervention; Disease; Epidemiologic Studies; Equilibrium; Estrogen Therapy; Estrogens; Face; Fatty acid glycerol esters; Fibrinogen; Future; Goals; Good Clinical Practice; Health; Health Care Seeking Behavior; Health Status; High Density Lipoprotein Cholesterol; Human; Individual; Insulin Resistance; International; Intervention; Ischemic Stroke; Link; Malignant Neoplasms; Medical; Mediterranean Diet; Mission; Monitor; National Institute on Alcohol Abuse and Alcoholism; Nutritional; Observational Study; Outcome; Participant; Pathway interactions; Patients; Peer Review; Pharmaceutical Preparations; Pharmacologic Substance; Physicians; Postmenopause; Process; Randomized; Recommendation; Research Personnel; Residual state; Review Literature; Risk; Scheme; Science; Suggestion; Testing; Uncertainty; Vulnerable Populations; Woman; Women' s Health; adiponectin; alcohol effect; base; cardiovascular disorder risk; cardiovascular risk factor; clinical practice; cost; drinking; experience; feeding; improved; interest; malignant breast neoplasm; meetings; men; mortality; randomized trial; research study; response; symposium

DESCRIPTION (provided by applicant): Moderate or low-risk alcohol consumption (defined by NIAAA as ≤4 drinks on any single day AND ≤14 drinks per week for men or ≤3 drinks on any single day AND ≤7 drinks per week for non-pregnant women) has been associated - despite its appellation - with a wide variety of health outcomes of the greatest import. Compared with abstainers or rare drinkers, moderate drinkers have been observed to have lower rates of coronary heart disease, congestive heart failure, ischemic stroke, diabetes, and cholelithiasis but higher rates of breast and possibly other cancers. Perhaps most compellingly, moderate alcohol intake has been associated with a lower risk of all-cause mortality, chiefly reflecting its inverse association with cardiovascular mortality. Important limitations affect this body of evidence, however. Although large and consistent epidemiological studies have been conducted, strong concerns about residual confounding by both health status and health- seeking behavior exist. The existing experimental studies of alcohol are small and short and, while demonstrating plausible mechanisms by which moderate drinking would lower cardiometabolic risk, the lack of correspondence between similar studies of postmenopausal estrogen treatment and the randomized Women's Health Initiative clinical trial only heightens this concern. Given the widespread use of alcohol, the clear risks and costs of its overuse, the uncertain balance of risks and benefits of moderate use, and the complete lack of definitive clinical trial data, the urgent is unmistakable. Our goal is to organize a satellite conference to he 2014 ISBRA/RSA meeting that brings together leaders in several domains, including experts in the conduct of feeding trials of moderate alcohol consumption, other complex nutritional interventions (such as low-fat or Mediterranean diet), and pharmaceutical interventions in individuals at high medical risk. Topics include: review of previous feeding studies of alcohol, existing recommendations from NIAAA and other agencies, effects of alcohol on biomarkers and outcomes in observational studies, lessons from nutritional and pharmaceutical Interventions, and future directions and recommendations. Participants from around the world will discuss these topics for an open audience of ISBRA/RSA attendees and other interested individuals, with plans to disseminate an overview of the conclusions and recommendations in the peer-reviewed literature.

描述（由申请人提供）：中度或低风险饮酒（NIAAA定义为男性任何一天饮酒≤4次且每周饮酒≤14次，或非妊娠女性任何一天饮酒≤3次且每周饮酒≤7次）与各种最重要的健康结果相关-尽管其名称如此。与不喝酒或很少喝酒的人相比，适度饮酒的人患冠心病、充血性心力衰竭、缺血性中风、糖尿病和胆石症的几率较低，但患乳腺癌和其他癌症的几率较高。也许最令人信服的是，适度饮酒与全因死亡率的风险较低有关，主要反映了其 与心血管死亡率呈负相关。然而，重要的局限性影响了这一证据。尽管已经进行了大量和一致的流行病学研究，但仍然存在对健康状况和寻求健康行为的残余混杂的强烈关注。现有的酒精实验研究规模小，时间短，虽然证明适度饮酒会降低心脏代谢风险的合理机制，但绝经后雌激素治疗的类似研究与随机妇女健康倡议临床试验之间缺乏对应性只会加剧这种担忧。鉴于酒精的广泛使用，过度使用的明显风险和成本，适度使用的风险和收益的不确定平衡，以及完全缺乏明确的临床试验数据，紧迫性是明确无误的。我们的目标是在2014年ISBRA/RSA会议上组织一次卫星会议，该会议汇集了多个领域的领导者，包括进行适度饮酒喂养试验的专家，其他复杂的营养干预措施（如低脂或地中海饮食），以及高医疗风险个体的药物干预措施。主题包括：回顾以往的酒精喂养研究，NIAAA和其他机构的现有建议，酒精对生物标志物的影响和观察性研究的结果，营养和药物干预的经验教训，以及未来的方向和建议。来自世界各地的与会者将为国际标准协会/标准协会的与会者和其他感兴趣的个人讨论这些主题，并计划在同行评审文献中传播结论和建议的概述。