Interventional and Feeding Studies of Alcohol

酒精的干预和喂养研究

• 批准号: 8785821
• 负责人: KENNETH Jay MUKAMAL
• 金额: $ 6.15万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-02-15 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8785821
• 关键词: Affect; Alcohol abuse; Alcohol consumption; Alcohols; Animals; Area; Atherosclerosis; Benefits and Risks; Biological; Biological Markers; Breast; Cardiovascular system; Cholelithiasis; Chronic Disease; Clinical Trials; Complex; Congestive Heart Failure; Coronary heart disease; Data; Diabetes Mellitus; Dietary Intervention; Disease; Epidemiologic Studies; Equilibrium; Estrogen Therapy; Estrogens; Face; Fatty acid glycerol esters; Fibrinogen; Future; Goals; Good Clinical Practice; Health; Health Care Seeking Behavior; Health Status; High Density Lipoprotein Cholesterol; Human; Individual; Insulin Resistance; International; Intervention; Ischemic Stroke; Link; Malignant Neoplasms; Medical; Mediterranean Diet; Mission; Monitor; National Institute on Alcohol Abuse and Alcoholism; Nutritional; Observational Study; Outcome; Participant; Pathway interactions; Patients; Peer Review; Pharmaceutical Preparations; Pharmacologic Substance; Physicians; Postmenopause; Process; Randomized; Recommendation; Research Personnel; Residual state; Review Literature; Risk; Scheme; Science; Suggestion; Testing; Uncertainty; Vulnerable Populations; Woman; Women' s Health; adiponectin; alcohol effect; base; cardiovascular disorder risk; cardiovascular risk factor; clinical practice; cost; drinking; experience; feeding; improved; interest; malignant breast neoplasm; meetings; men; mortality; randomized trial; research study; response; symposium

DESCRIPTION (provided by applicant): Moderate or low-risk alcohol consumption (defined by NIAAA as ≤4 drinks on any single day AND ≤14 drinks per week for men or ≤3 drinks on any single day AND ≤7 drinks per week for non-pregnant women) has been associated - despite its appellation - with a wide variety of health outcomes of the greatest import. Compared with abstainers or rare drinkers, moderate drinkers have been observed to have lower rates of coronary heart disease, congestive heart failure, ischemic stroke, diabetes, and cholelithiasis but higher rates of breast and possibly other cancers. Perhaps most compellingly, moderate alcohol intake has been associated with a lower risk of all-cause mortality, chiefly reflecting its inverse association with cardiovascular mortality. Important limitations affect this body of evidence, however. Although large and consistent epidemiological studies have been conducted, strong concerns about residual confounding by both health status and health- seeking behavior exist. The existing experimental studies of alcohol are small and short and, while demonstrating plausible mechanisms by which moderate drinking would lower cardiometabolic risk, the lack of correspondence between similar studies of postmenopausal estrogen treatment and the randomized Women's Health Initiative clinical trial only heightens this concern. Given the widespread use of alcohol, the clear risks and costs of its overuse, the uncertain balance of risks and benefits of moderate use, and the complete lack of definitive clinical trial data, the urgent is unmistakable. Our goal is to organize a satellite conference to he 2014 ISBRA/RSA meeting that brings together leaders in several domains, including experts in the conduct of feeding trials of moderate alcohol consumption, other complex nutritional interventions (such as low-fat or Mediterranean diet), and pharmaceutical interventions in individuals at high medical risk. Topics include: review of previous feeding studies of alcohol, existing recommendations from NIAAA and other agencies, effects of alcohol on biomarkers and outcomes in observational studies, lessons from nutritional and pharmaceutical Interventions, and future directions and recommendations. Participants from around the world will discuss these topics for an open audience of ISBRA/RSA attendees and other interested individuals, with plans to disseminate an overview of the conclusions and recommendations in the peer-reviewed literature.

描述（适用提供）：中等或低风险的酒精消耗（由NIAAA定义为任何一天的≤4饮料，男性每周每天≤14杯饮料，或每天≤3饮料，非怀孕的女性每天≤3饮料，每周≤7饮料）已与之相关联 - 目的地与大量的健康相关联。与Abtainers或稀有饮酒者相比，已经观察到中度饮酒者的冠状动脉疾病率较低，充血性心力衰竭，缺血性中风，糖尿病和胆石症，但乳腺癌和其他可能的癌症发生率较高。也许最引人注目的是，适度的酒精摄入与全因死亡率的较低风险有关，主要反映其 与心血管死亡率的逆关联。但是，重要的局限性影响了这一证据体系。尽管已经进行了大量且一致的流行病学研究，但对健康状况和寻求健康的行为的残留混淆的强烈关注。现有的对酒精的实验研究小而短，同时证明了合理的机制，中等饮酒会降低心脏代谢风险，但绝经后雌激素治疗的类似研究与随机妇女健康临床临床试验之间缺乏对应关系，只会使这种关注度更高。鉴于酒精的宽度使用，其过度使用的明显风险和成本，中等使用的风险和收益的不确定平衡以及完全缺乏确定的临床试验数据，紧急情况是无疑的。我们的目标是在2014年的ISBRA/RSA会议上组织一次卫星会议，该会议将一些领域的领导者汇集在一起​​，包括进行适度饮酒的喂养试验的专家，其他复杂的营养干预措施（例如低脂或地中海饮食）以及对高医疗风险的患者中的药物干预措施。主题包括：审查先前对酒精的喂养研究，NIAAA和其他机构的现有建议，酒精对生物标志物的影响和观察性研究中的结果，营养和药品干预的经验教训以及未来的方向和建议。来自世界各地的参与者将为ISBRA/RSA与会者和其他有趣的人讨论这些主题，并计划概述经过同行评审的文学中的结论和建议。