Interventional and Feeding Studies of Alcohol

酒精的干预和喂养研究

• 批准号: 8785821
• 负责人: KENNETH Jay MUKAMAL
• 金额: $ 6.15万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-02-15 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8785821
• 关键词: Affect; Alcohol abuse; Alcohol consumption; Alcohols; Animals; Area; Atherosclerosis; Benefits and Risks; Biological; Biological Markers; Breast; Cardiovascular system; Cholelithiasis; Chronic Disease; Clinical Trials; Complex; Congestive Heart Failure; Coronary heart disease; Data; Diabetes Mellitus; Dietary Intervention; Disease; Epidemiologic Studies; Equilibrium; Estrogen Therapy; Estrogens; Face; Fatty acid glycerol esters; Fibrinogen; Future; Goals; Good Clinical Practice; Health; Health Care Seeking Behavior; Health Status; High Density Lipoprotein Cholesterol; Human; Individual; Insulin Resistance; International; Intervention; Ischemic Stroke; Link; Malignant Neoplasms; Medical; Mediterranean Diet; Mission; Monitor; National Institute on Alcohol Abuse and Alcoholism; Nutritional; Observational Study; Outcome; Participant; Pathway interactions; Patients; Peer Review; Pharmaceutical Preparations; Pharmacologic Substance; Physicians; Postmenopause; Process; Randomized; Recommendation; Research Personnel; Residual state; Review Literature; Risk; Scheme; Science; Suggestion; Testing; Uncertainty; Vulnerable Populations; Woman; Women' s Health; adiponectin; alcohol effect; base; cardiovascular disorder risk; cardiovascular risk factor; clinical practice; cost; drinking; experience; feeding; improved; interest; malignant breast neoplasm; meetings; men; mortality; randomized trial; research study; response; symposium

DESCRIPTION (provided by applicant): Moderate or low-risk alcohol consumption (defined by NIAAA as ≤4 drinks on any single day AND ≤14 drinks per week for men or ≤3 drinks on any single day AND ≤7 drinks per week for non-pregnant women) has been associated - despite its appellation - with a wide variety of health outcomes of the greatest import. Compared with abstainers or rare drinkers, moderate drinkers have been observed to have lower rates of coronary heart disease, congestive heart failure, ischemic stroke, diabetes, and cholelithiasis but higher rates of breast and possibly other cancers. Perhaps most compellingly, moderate alcohol intake has been associated with a lower risk of all-cause mortality, chiefly reflecting its inverse association with cardiovascular mortality. Important limitations affect this body of evidence, however. Although large and consistent epidemiological studies have been conducted, strong concerns about residual confounding by both health status and health- seeking behavior exist. The existing experimental studies of alcohol are small and short and, while demonstrating plausible mechanisms by which moderate drinking would lower cardiometabolic risk, the lack of correspondence between similar studies of postmenopausal estrogen treatment and the randomized Women's Health Initiative clinical trial only heightens this concern. Given the widespread use of alcohol, the clear risks and costs of its overuse, the uncertain balance of risks and benefits of moderate use, and the complete lack of definitive clinical trial data, the urgent is unmistakable. Our goal is to organize a satellite conference to he 2014 ISBRA/RSA meeting that brings together leaders in several domains, including experts in the conduct of feeding trials of moderate alcohol consumption, other complex nutritional interventions (such as low-fat or Mediterranean diet), and pharmaceutical interventions in individuals at high medical risk. Topics include: review of previous feeding studies of alcohol, existing recommendations from NIAAA and other agencies, effects of alcohol on biomarkers and outcomes in observational studies, lessons from nutritional and pharmaceutical Interventions, and future directions and recommendations. Participants from around the world will discuss these topics for an open audience of ISBRA/RSA attendees and other interested individuals, with plans to disseminate an overview of the conclusions and recommendations in the peer-reviewed literature.

描述（由申请人提供）：中度或低风险饮酒（NIAAA定义为男性每天≤4杯，每周≤14杯，非孕妇每天≤3杯，每周≤7杯）与各种最重要的健康结果相关-尽管其名称。与不饮酒者或很少饮酒者相比，适度饮酒者患冠心病、充血性心力衰竭、缺血性中风、糖尿病和胆石症的几率较低，但患乳腺癌和其他癌症的几率较高。也许最令人信服的是，适度饮酒与全因死亡风险较低有关，这主要反映了其对健康的影响