Mid-Career Research and Mentorship in Metabolic Aging

代谢衰老的职业中期研究和指导

• 批准号: 10610877
• 负责人: KENNETH Jay MUKAMAL
• 金额: $ 18.47万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10610877
• 关键词: Adipocytes; Adult; Adverse effects; Affect; Aging; Alzheimer' s disease related dementia; Atrial Fibrillation; Award; Biological Specimen Banks; Blood; Cardiovascular Diseases; Cardiovascular system; Cessation of life; Clinical Investigator; Clinical Research; Cognitive; Cohort Studies; Communities; Congestive Heart Failure; Dementia; Diabetes Mellitus; Education; Educational Curriculum; Elderly; Environment; Evaluation; Event; Familiarity; Fatty Acids; Fatty acid glycerol esters; Funding; Ginkgo biloba; Glucose; Goals; Health; Human; Impaired cognition; Impairment; Individual; Internal Medicine; Internist; Israel; Knowledge; Lipolysis; Measurement; Medical center; Memory; Mentors; Mentorship; Metabolic; Metabolism; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; National Heart, Lung, and Blood Institute; Organ; Outcome; Participant; Phenotype; Physical Performance; Play; Population; Population Study; Positioning Attribute; Public Health Schools; Research; Research Personnel; Research Support; Residencies; Role; Scientist; Students; Testing; Training; Training Programs; Underrepresented Minority; Work; adjudication; adverse outcome; age related; blood-brain barrier crossing; burden of illness; cardiometabolism; cardiovascular health; career; clinical database; cognitive testing; cohort; data resource; diabetes risk; epidemiology study; experience; follow-up; frailty; glucose metabolism; high risk; human old age (65+); improved; instrumental activity of daily living; lipid metabolism; medical schools; member; metabolic abnormality assessment; minority scientist; mortality; neuroimaging; neuropsychiatry; next generation; patient oriented research; programs; radiological imaging; randomized trial; research study; response; sugar; working group

Project Summary/Abstract Dysregulation of glucose and lipid metabolism are central features of human aging and play major roles in the highly morbid cardiometabolic conditions prevalent among older adults, including cardiovascular disease, diabetes, and congestive heart failure. Non-esterified, or free, fatty acids (NEFAs) have long been implicated as central actors in impaired metabolism and may underlie many of the adverse effects of metabolic aging, including cognitive decline and frailty. Dr. Kenneth Mukamal, a general internist, has undertaken broad-based epidemiological research with a particular focus on metabolic determinants of cardiovascular and cognitive outcomes among older adults. This research has largely centered on the Cardiovascular Health Study (CHS), an NHLBI- and NIA-funded cohort study of 5,888 adults aged 65 and older from four U.S. communities, and the Ginkgo Evaluation of Memory Study (GEMS), a randomized trial that conducted additional dementia follow-up in a subset of CHS participants. Dr. Mukamal serves as a member of the CHS Steering Committee and chairs its Diabetes Working Group. Dr. Mukamal’s ongoing research support (R01-AG-053325) funds measurement of total, individual and post-glucose-load NEFAs in the unique CHS cohort. His recent work has demonstrated that total NEFAs are associated with cognitive decline and adjudicated dementia in CHS. Supported by two recent supplements – one to support an underrepresented minority scientist whom Dr. Mukamal mentors and a second to support ADRD research in response to NOT-AG-18-008 – Dr. Mukamal is now actively investigating the role of individual and post-load NEFAs in dementia and frailty in CHS and elsewhere. Dr. Mukamal has a long, consistent, and distinguished track record of mentoring young scientists, serving in major educational roles across a variety of settings and having received formal recognition for his outstanding research mentorship. A Midcareer Investigator Award in Patient-Oriented Research would enable him to expand and deepen his commitment to mentoring by reducing his administrative responsibilities and providing direct support for focused, intensive mentoring activities that specifically relate to metabolic impairment in aging. In addition, this award would enable Dr. Mukamal to further develop his own career and gain knowledge, familiarity, and expertise in domains crucial to the further extension of his work into dementia, such as advances in cognitive assessment and neuroimaging. In conjunction with the outstanding environments for training and mentoring at Beth Israel Deaconess Medical Center, Harvard Medical School, and the Harvard TH Chan School of Public Health, this award will enable Dr. Mukamal to expand and improve his mentoring experience and, as a result, help to train the next generation of investigators in metabolic aging.

项目总结/摘要 葡萄糖和脂质代谢的失调是人类衰老的中心特征，并且在人类衰老中起主要作用。 老年人中普遍存在的高度病态的心脏代谢疾病，包括心血管疾病， 糖尿病和充血性心力衰竭非酯化或游离脂肪酸（NEFA）长期以来一直与 作为代谢受损的主要因素并且可能是代谢老化的许多不利影响的基础， 包括认知能力下降和虚弱 博士Kenneth Mukamal是一名普通内科医生，他进行了广泛的流行病学研究， 特别关注老年人心血管和认知结果的代谢决定因素。这 研究主要集中在心血管健康研究（CHS），这是一项由NHLBI和NIA资助的队列研究 来自美国四个社区的5，888名65岁及以上的成年人的研究，以及银杏记忆评估 研究（GEMS），一项在CHS亚组中进行额外痴呆随访的随机试验 参与者Mukamal博士是CHS指导委员会的成员，并主持其糖尿病 工作组。Mukamal博士正在进行的研究支持（R01-AG-053325）为测量总的， 在独特的CHS队列中的个体和葡萄糖负荷后NEFA。他最近的工作表明， 总NEFA与CHS中认知能力下降和判定的痴呆相关。支持两个最近 补充-一个是支持一个代表性不足的少数民族科学家谁博士穆卡马尔导师和一个 其次是支持ADRD研究，以响应NOT-AG-18 - 008-Mukamal博士目前正在积极调查 个体和负荷后NEFA在CHS和其他地方痴呆和虚弱中的作用。 博士Mukamal在指导年轻科学家方面有着长期、一贯和杰出的记录， 在各种环境中担任重要的教育角色，并因其杰出的表现而获得正式认可 研究指导。在以患者为导向的研究中获得职业中期研究者奖将使他能够 通过减少他的行政责任和提供 直接支持重点突出的强化指导活动，特别是与代谢障碍有关的活动， 衰老此外，这一奖项将使Mukamal博士能够进一步发展自己的职业生涯， 知识，熟悉和专业领域的关键，他的工作进一步扩展到痴呆症，如 认知评估和神经影像学的进步结合出色的环境， 在贝斯以色列女执事医疗中心、哈佛医学院和哈佛TH进行培训和指导 Chan公共卫生学院，该奖项将使Mukamal博士能够扩大和改善他的指导 经验，因此，有助于培养下一代的研究人员在代谢老化。