Mid-Career Research and Mentorship in Metabolic Aging

代谢衰老的职业中期研究和指导

• 批准号: 10248290
• 负责人: KENNETH Jay MUKAMAL
• 金额: $ 18.54万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10248290
• 关键词: Adipocytes; Adult; Adverse effects; Affect; Aging; Alzheimer' s disease related dementia; Atrial Fibrillation; Award; Biological Specimen Banks; Blood; Blood - brain barrier anatomy; Cardiovascular Diseases; Cardiovascular system; Cessation of life; Clinical Investigator; Clinical Research; Cognitive; Cohort Studies; Communities; Congestive Heart Failure; Dementia; Diabetes Mellitus; Educational Curriculum; Elderly; Environment; Evaluation; Event; Familiarity; Fatty Acids; Fatty acid glycerol esters; Funding; Ginkgo biloba; Glucose; Goals; Health; Human; Impaired cognition; Impairment; Individual; Internal Medicine; Internist; Israel; Knowledge; Lipolysis; Measurement; Medical center; Memory; Mentors; Mentorship; Metabolic; Metabolism; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; National Heart, Lung, and Blood Institute; Nonesterified Fatty Acids; Organ; Outcome; Participant; Phenotype; Physical Performance; Play; Population; Population Study; Positioning Attribute; Public Health Schools; Research; Research Personnel; Research Support; Residencies; Role; Scientist; Students; Training; Training Programs; Underrepresented Minority; Work; adjudicate; adverse outcome; age related; base; burden of illness; cardiometabolism; cardiovascular health; career; clinical database; cognitive testing; cohort; data resource; diabetes risk; epidemiology study; experience; follow-up; frailty; glucose metabolism; high risk; human old age (65+); improved; instrumental activity of daily living; lipid metabolism; medical schools; member; metabolic abnormality assessment; minority scientist; mortality; neuroimaging; neuropsychiatry; next generation; patient oriented research; programs; radiological imaging; randomized trial; research study; response; sugar; working group

Project Summary/Abstract Dysregulation of glucose and lipid metabolism are central features of human aging and play major roles in the highly morbid cardiometabolic conditions prevalent among older adults, including cardiovascular disease, diabetes, and congestive heart failure. Non-esterified, or free, fatty acids (NEFAs) have long been implicated as central actors in impaired metabolism and may underlie many of the adverse effects of metabolic aging, including cognitive decline and frailty. Dr. Kenneth Mukamal, a general internist, has undertaken broad-based epidemiological research with a particular focus on metabolic determinants of cardiovascular and cognitive outcomes among older adults. This research has largely centered on the Cardiovascular Health Study (CHS), an NHLBI- and NIA-funded cohort study of 5,888 adults aged 65 and older from four U.S. communities, and the Ginkgo Evaluation of Memory Study (GEMS), a randomized trial that conducted additional dementia follow-up in a subset of CHS participants. Dr. Mukamal serves as a member of the CHS Steering Committee and chairs its Diabetes Working Group. Dr. Mukamal’s ongoing research support (R01-AG-053325) funds measurement of total, individual and post-glucose-load NEFAs in the unique CHS cohort. His recent work has demonstrated that total NEFAs are associated with cognitive decline and adjudicated dementia in CHS. Supported by two recent supplements – one to support an underrepresented minority scientist whom Dr. Mukamal mentors and a second to support ADRD research in response to NOT-AG-18-008 – Dr. Mukamal is now actively investigating the role of individual and post-load NEFAs in dementia and frailty in CHS and elsewhere. Dr. Mukamal has a long, consistent, and distinguished track record of mentoring young scientists, serving in major educational roles across a variety of settings and having received formal recognition for his outstanding research mentorship. A Midcareer Investigator Award in Patient-Oriented Research would enable him to expand and deepen his commitment to mentoring by reducing his administrative responsibilities and providing direct support for focused, intensive mentoring activities that specifically relate to metabolic impairment in aging. In addition, this award would enable Dr. Mukamal to further develop his own career and gain knowledge, familiarity, and expertise in domains crucial to the further extension of his work into dementia, such as advances in cognitive assessment and neuroimaging. In conjunction with the outstanding environments for training and mentoring at Beth Israel Deaconess Medical Center, Harvard Medical School, and the Harvard TH Chan School of Public Health, this award will enable Dr. Mukamal to expand and improve his mentoring experience and, as a result, help to train the next generation of investigators in metabolic aging.

项目摘要/摘要 葡萄糖和脂质代谢的失调是人类衰老的核心特征，在 老年人中普遍存在的高病态心脏代谢状况，包括心血管疾病， 糖尿病和充血性心力衰竭。长期以来，非酯化或游离的脂肪酸（NEFA）已涉及 作为中央参与者的新陈代谢受损，可能是代谢衰老的许多不良影响的基础 包括认知能力下降和脆弱。 普通国际医师肯尼斯·穆卡马尔（Kenneth Mukamal）博士通过A进行了广泛的流行病学研究 特别关注老年人心血管和认知结果的代谢决定者。这 研究主要集中于心血管健康研究（CHS），NHLBI-和NIA资助的队列 研究来自四个美国社区的5,888名65岁及65岁以上的成年人以及银杏记忆评估 研究（GEMS），一项随机试验，在CHS的一部分中进行了额外的痴呆随访 参与者。 Mukamal博士担任CHS指导委员会的成员，并主持其糖尿病 工作组。 Mukamal博士正在进行的研究支持（R01-AG-053325）资金总数，总计 独特的CHS队列中的个体和葡萄糖后负载NEFA。他最近的工作表明 NEFA与CHS的认知能力下降和调整痴呆有关。由最近两个 补品 - 一个支持穆卡马尔（Mukamal）博士指导者和A 第二支持ADRD研究以响应非AG-18-008 - Mukamal博士现在正在积极研究 个体和载后NEFA在CHS和其他地方的痴呆症和脆弱性中的作用。 Mukamal博士拥有指导年轻科学家的漫长，一致且杰出的记录， 在各种环境中的主要教育角色，并因其杰出而获得正式认可 研究指导。以患者为导向的研究获得的中级研究员奖将使他能够 通过减少其行政责任并提供 直接支持集中的，密集的心理活动，这些活动与代谢障碍特别相关 老化。此外，该奖项将使Mukamal博士能够进一步发展自己的职业并获得 知识，熟悉和专业知识在领域，对他的工作进一步扩展到痴呆症至关重要， 随着认知评估和神经影像学的进步。结合出色的环境 贝丝以色列女执事医学中心，哈佛医学院和哈佛大学培训和心理 陈公共卫生学院，该奖项将使Mukamal博士能够扩大和改善他的心理 因此，经验并有助于培训下一代研究人员的代谢衰老。