Smart Early Screening for Autism and Communication Disorders in Primary Care

描述（由申请人提供）：由于研究表明早期干预能使结果最大化，因此迫切需要建立社区的能力，以遵循美国儿科学会的指导方针，对所有18和24个月大的儿童进行ASD筛查（Johnson & Myers, 2007）。作为对PA-10-158的回应，这项调查的主要目的是验证一个新的自动化在线版本的自闭症和沟通障碍早期筛查的有效性——“智能ESAC”，它使用智能技术无缝地从10个关于沟通延迟的宽带问题过渡到20个自闭症特定问题，这些问题针对的是在初始宽带屏幕上筛查为阳性的儿童。智能ESAC被设计为12个月和18个月大的沟通迟缓和ASD的通用屏幕。我们将通过佛罗里达州狭长地带的社区初级保健提供者（pcp）对智能ESAC的有效性进行大规模的纵向研究，该地区提供小型城市和农村医疗保健机构，种族，民族和社会经济水平的多样性。我们还将研究家庭参与筛查和诊断，以改善健康差距。我们将招募多达32名pcp，他们将对8,424名12个月大的婴儿进行筛查，并在该项目的5年内对这些儿童进行纵向跟踪。我们将邀请家庭参与所有儿童的诊断评估

DESCRIPTION (provided by applicant): There is a pressing need to build the capacity of communities to follow the guidelines of the American Academy of Pediatrics to screen all children for ASD at 18 and 24 months (Johnson & Myers, 2007) as research indicates that earlier intervention maximizes outcomes. In response to PA-10-158, the overarching purpose of this investigation is to validate the effectiveness of a new automated online version of the Early Screening for Autism and Communication Disorders- the "Smart ESAC," that uses smart technology to seamlessly transition from 10 broadband questions about communication delay to 20 autism-specific questions for children who screen positive on the initial broadband screen. The Smart ESAC is designed as a universal screen for communication delays and ASD at 12 and 18 months of age. We will conduct a large-scale longitudinal study of the validity of the Smart ESAC through community primary care providers (PCPs) in the Florida panhandle, which offers small urban and rural healthcare settings and diversity in race, ethnicity, and socioeconomic level. We will also study family engagement in screening and diagnosis to improve health disparities. We will recruit up to 32 PCPs who will implement screening with 8,424 infants at 12 months of age and follow these children longitudinally over the 5 years of this project. We will invite families to participate in diagnostic evaluations for all children who screen positive and randomly selected children with a negative screen to detect about 842 children with communication delays and about 84 children with ASD. This longitudinal study will address the following specific aims: Aim 1. To study the established cutoff points and estimate sensitivity, specificity, and discrimination for the Smart ESAC at 12 and 18 months in predicting communication delay or red flags for autism at 12 and 18 months, and in predicting distally a best-estimate diagnosis of ASD at 18-24 and 30-36 months; Aim 2. To study individual items and underlying dimensions of the constructs measured by the Smart ESAC using factor analysis and item response theory to determine the number of factors and differential item function within factors, to ultimately predict diagnostic outcome; and Aim 3. To identify barriers in community settings that impede the screening and referral process and culturally sensitive strategies that function to improve this process. The expected outcomes of the proposed research will have a significant impact on early detection of communication disorders and ASD through documentation of the accuracy of a new promising universal automated screening tool for infants and toddlers. This study will also impact family engagement in community screening processes through the development of a manualized engagement intervention based on Motivational Interviewing and family-centered strategies. Findings will also contribute one of the largest and youngest samples of infants and toddlers identified in primary care, with the potential of lowering the age to screen for communication delay and ASD to 12 months, which will have important implications for earlier access to intervention and immediate implementation in community settings.