Validation of the Social Communication CheckUp and Autism Risk Indicator in the First Year of Life

生命第一年社交沟通检查和自闭症风险指标的验证

• 批准号: 10245103
• 负责人: AMY M WETHERBY
• 金额: $ 59.13万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-18 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10245103
• 关键词: Address; Age; Age-Months; Algorithms; Biomedical Research; Centers for Disease Control and Prevention (U.S.); Child; Child Care; Child Rearing; Clinical; Clip; Communication; Communication impairment; Communities; Data; Development; Diagnosis; Diagnostic; Early Intervention; Effectiveness; Ethnic Origin; Evaluation; Factor Analysis; Family; Florida; General Population; Genetic Research; Goals; Growth; Guidelines; Health education; Home; Infant; Intercept; Intervention; Intervention Studies; Language; Lead; Learning; Life; Link; Longitudinal Studies; Measures; Methodology; Methods; Narration; Outcome; Parents; Primary Care Physician; Primary Health Care; Psychometrics; Race; Reporting; Research; Research Personnel; Research Project Grants; Risk; Sampling; Science; Screening procedure; Sensitivity and Specificity; Severities; Social Discrimination; Symptoms; System; Testing; Time; Toddler; Validation; Well Child Visits; autism community; autism spectrum disorder; base; checkup examination; community setting; cost effective; design; early screening; effective intervention; effectiveness validation; health care delivery; health care settings; implementation science; improved; innovative technologies; kindergarten; mobile application; recruit; response; rural healthcare; screening; skills; social communication; socioeconomics; theories; tool; user-friendly; validation studies; web app

PROJECT ABSTRACT In response to RFA-MH-19-120, the goal of this study is to validate the effectiveness of a new automated online screening tool—the Social Communication (SoCo) CheckUp—that incorporates empirically-tested screening items for communication delay and autism spectrum disorder (ASD) in 3-month age intervals. This new screening tool is designed for universal screening at well-child visits at 9, 12, 15, 18, 21, and 24 months of age to screen for communication delay and autism. The SoCo CheckUp is part of our Baby Navigator portal, a new mobile application that includes the SoCo Growth Charts—a developmental surveillance for families to answer questions about SoCo milestones every 2 months to chart their child’s growth in 5 domains and to explore hundreds of video clips illustrating early milestones with narration on responsive parenting. Families with a positive autism screen have links to three ASD-specific tools. We will recruit 4,000 infants by 2 months of age at one of their first well child visits and invite families to the SoCo Growth Charts for developmental surveillance. We will then invite families into the portal to screen with the SoCo Checkup based on parent report at 9 months, with repeat screenings at 12, 15, 18, 21, and 24 months. All families of children with a positive autism screen on the SoCo Checkup and a comparable number of children with a negative screen will be invited to collect home observations for an observational screener using the Systematic Observation of Red Flags of ASD (SORF) at the same ages from 9-24 months. All children with a positive ASD screen on the SORF and a comparable number of children randomly select with a negative SORF screen will be invited for a confirmatory diagnostic evaluation at 24 months. We anticipate confirming ASD for least 80 children based on previous research detecting 1/50. We will address the following research aims: Aim 1. Study psychometric features of the SoCo Checkup cut- off and composite to diagnostic outcome; Aim 2. Study the trajectories of the SoCo surveillance and screening to predict autism symptom severity; and Aim 3. Construct a risk algorithm based on multiple parameters to develop an efficient, cost-effective mobile screening application for use in infants that is readily deployable in the general population. The expected outcomes of this validation study will demonstrate the effectiveness of an online surveillance and screening system beginning in the first year of life that will be ready for immediate, rapid, scalable, and sustainable deployment across the US. Findings will advance science by providing researchers with a method for recruiting a community sample, allowing for research at younger ages, which could accelerate genetic, biomedical, and intervention research. The use of innovative technology, user-friendly tools and web- applications, and implementation science methodology enhances the potential for sustainability and scalability that can lead to transformative changes to efficiently and effectively screen infants for communication delay and autism and improve healthcare delivery.

项目摘要 为了回应RFA-MH-19-120，这项研究的目的是验证新自动化在线的有效性 筛选工具 - 社交交流（SOCO）检查 - 结合了经验测试的筛查 沟通延迟和自闭症谱系障碍（ASD）的项目以3个月的间隔。这个新的筛选 工具专为在9、12、15、18、21和24个月大的筛查时专用于环球筛查 用于沟通延迟和自闭症。 SOCO检查是我们婴儿导航器门户的一部分，这是一种新的手机 包括SOCO增长图表在内的应用 - 家庭回答的发展监视 每2个月有关SOCO里程碑的问题，以绘制孩子在5个领域的成长并进行探索 数百个视频剪辑以响应式育儿的导航为早期里程碑。有一个家庭 积极的自闭症屏幕具有指向三种ASD特定工具的链接。我们将在2个月大时招募4,000名婴儿 他们的第一个良好的儿童访问之一，并邀请家庭访问Soco增长图表进行发展监视。 然后，我们将邀请家庭进入门户网站，并根据9个月的父母报告进行SOCO检查， 在12、15、18、21和24个月时重复筛选。所有具有积极自闭症屏幕的儿童家庭 SOCO检查和可比数量的具有负屏幕的儿童将被邀请收集家 使用对ASD（SORF）的危险信号的观察筛选器观察 从9-24个月开始相同的年龄。所有在Sorf上有正ASD屏幕的儿童和可比的数字 将邀请使用负SORF屏幕随机选择的儿童进行确认诊断评估 在24个月。我们预计，基于先前的研究检测1/50，至少80名儿童为ASD确认。 我们将解决以下研究目的：目标1。研究SOCO检查切割的心理测量特征 - 关闭并复合诊断结果；目标2。研究SOCO监视和筛查的轨迹 预测自闭症症状严重程度；目标3。基于多个参数构建风险算法 开发有效，具有成本效益的移动筛查应用程序，以便在婴儿中使用 一般人口。这项验证研究的预期结果将证明 在线监视和筛查系统从生命的第一年开始，该系统将准备立即，快速，快速， 在美国各地可扩展和可持续部署。调查结果将通过为研究人员提供来推进科学 采用招募社区样本的方法，允许在年轻人中进行研究，这可能会加速 遗传，生物医学和干预研究。使用创新技术，用户友好的工具和网络的使用 应用和实施科学方法可以增强可持续性和可扩展性的潜力 这可能会导致有效有效地筛查婴儿的交流延迟和 自闭症并改善医疗保健服务。