Autism Adaptive Community-based Treatment to Improve Outcomes using Navigators (ACTION) Network

使用导航器（ACTION）网络改善自闭症适应性社区治疗结果

• 批准号: 10237197
• 负责人: AMY M WETHERBY
• 金额: $ 186.44万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-07 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10237197
• 关键词: 5 year old; Adaptive Behaviors; Address; Adoption; Age; Age-Months; California; Caring; Child; Church; Clinical; Clinical Research; Clinical Trials; Clinical effectiveness; Collection; Communities; Community Health Aides; Detection; Development; Diagnosis; Dose; Early Diagnosis; Early Intervention; Education; Educational Curriculum; Evaluation; Evidence based intervention; Evidence based practice; Face; Family; Feasibility Studies; Florida; Genetic Research; Geography; Growth; Health Services Accessibility; Healthcare; Healthcare Systems; Home; Individual; Industry; Infant; Infrastructure; Institution; Intervention; Intervention Studies; Investments; Lead; Learning; Linguistics; Low income; Massachusetts; Measures; Mental Health; Methods; Minority; Modeling; Neuronal Plasticity; Neurosciences Research; Online Systems; Outcome; Outcome Measure; Parents; Phase; Policies; Population; Primary Health Care; Problem Solving; Process; Process Measure; Public Health; Research; Research Personnel; Resources; Science; Science Policy; Scientific Advances and Accomplishments; Sequential Multiple Assignment Randomized Trial; Services; Site; Social Interaction; Social outcome; Societies; Students; Symptoms; System; Technology; Testing; Toddler; Training; Workforce Development; acceptability and feasibility; adaptive intervention; autism community; autism spectrum disorder; autistic children; base; community based treatment; compare effectiveness; comparison intervention; cost; cost efficient; digital media; effectiveness research; evidence base; feasibility testing; field study; follow-up; health care delivery; health disparity; hybrid type 1 design; implementation design; implementation science; implementation strategy; improved; improved outcome; mobile computing; motivational enhancement therapy; novel; outreach; rapid technique; recruit; research to practice; response; rural families; scale up; screening; screening guidelines; screening program; service gap; skills; social communication; societal costs; socioeconomics; success; tool; trial design; uptake; workforce needs

PROJECT ABSTRACT Research shows that a stable diagnosis of autism spectrum disorder (ASD) can be made by trained professionals at 18-24 months and yet the median age of diagnosis in the US is 4-5 years of age. Lower income, minority, and rural families receive a diagnosis up to 1.5 years later and more likely miss the window of opportunity for early intervention (EI). One of the greatest challenges we face, in spite of scientific advances and investments, is how to bridge the healthcare science-to-service gap and address health disparities in access to evidence-based EI for children with ASD. Doing this would be the best solution to improve lifelong outcomes, reduce costs to society, and change the landscape of autism. In response to RFA-MH-17-008, the Autism ACTION Network—a new interdisciplinary network of 8 institutions—will blend clinical effectiveness and implementation research designs to study individual and combined effects of 2 evidence-based interventions in real world settings: 1) engage families to access resources and support when they first learn their child has signs of ASD using an evidence-based intervention that integrates motivational interviewing and problem- solving education (MI+PSE); and 2) coach families to embed evidence-based intervention strategies for toddlers with ASD in everyday activities using the Early Social Interaction (ESI) model. Building on existing infrastructure, we will infuse mobile technology using the Autism Navigator® collection of web-based courses and tools. Families will be recruited by screening in community-based primary care and EI systems in 3 diverse regions in 2 states: Florida and Massachusetts. In Phase 1, we will compare the effectiveness of adaptive interventions that use MI+PSE with and without ESI in a 2-stage Sequential Multiple Assignment Randomized Trial (SMART) design on family engagement in EI, parent use of intervention strategies in everyday activities, and child outcomes of social communication, active engagement, autism symptoms, developmental level, and adaptive behavior. In Phase 2, we will construct an adaptive intervention to optimize the effects of MI+PSE with ESI based on the SMART and study the feasibility of implementation in two new service systems in California--Kaiser Permanente Healthcare System and the National Black Church Initiative. This network brings a unique interdisciplinary team with expertise spanning early detection, maternal mental health, clinical trials, health disparities, implementation science, and policy. Our dynamic technology platform has ambitious dissemination aims of informing a community of change agents committed to impact at the population level. This research network can build the capacity of community-based systems to provide earlier and widespread access to cost-efficient, community-viable treatment and be ready for immediate and rapid implementation across the US. Findings will advance science by providing researchers with a method for rapidly deploying evidence-based practices, enabling research at younger ages—accelerating genetic, neuroscience, and intervention research—and lead to transformative changes in workforce development and healthcare delivery.

项目摘要

项目成果

The influence of loss to follow-up in autism screening research: Taking stock and moving forward.

自闭症筛查研究中失访对随访的影响：盘点并前进。

• DOI: 10.1111/jcpp.13867
• 发表时间: 2024
• 期刊: Journal of child psychology and psychiatry, and allied disciplines
• 作者: Sheldrick,RChristopher;Hooker,JessicaL;Carter,AliceS;Feinberg,Emily;Croen,LisaA;Kuhn,Jocelyn;Slate,Elizabeth;Wetherby,AmyM
• 通讯作者: Wetherby,AmyM

The earlier the better: An RCT of treatment timing effects for toddlers on the autism spectrum.

• DOI: 10.1177/13623613231159153
• 发表时间: 2023-03-15
• 期刊: AUTISM
• 影响因子: 5.2
• 作者: Guthrie, Whitney;Wetherby, Amy M.;Woods, Juliann;Schatschneider, Christopher;Holland, Renee D.;Morgan, Lindee;Lord, Catherine E.
• 通讯作者: Lord, Catherine E.