Investigating Early Social Communication Trajectories of Late Talking Toddlers to Best Predict Language Outcomes for the NIH TALK Initiative

调查晚说话幼儿的早期社交沟通轨迹，以最好地预测 NIH TALK 计划的语言结果

• 批准号: 10842062
• 负责人: AMY M WETHERBY
• 金额: $ 57.21万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-18 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10842062
• 关键词: 4 year old; Address; Administrative Supplement; Age Months; Algorithms; Autism diagnostic; Child; Child Rearing; Code; Communication; Data; Development; Developmental Delay Disorders; Diagnostic; Early Diagnosis; Education; Effectiveness; Evaluation; Family; General Population; Goals; Home; Infant; Investigation; Language; Language Delays; Life; Measures; Outcome; Parents; Psychometrics; Reporting; Research; Risk; Sampling; Screening procedure; Severities; System; Testing; Toddler; United States National Institutes of Health; autism spectrum disorder; checkup examination; comparison group; cost effective; effectiveness validation; follow-up; improved; language outcome; parent grant; recruit; response; screening; skills; social communication; social culture; social observations; validation studies

ABSTRACT The goal of the parent R01 MH121364 investigation is to validate the effectiveness of a new automated online screening tool based on parent report—the Social Communication (SoCo) CheckUp—which incorporates empirically-tested screening items for communication delay and autism spectrum disorder (ASD). The parent investigation is recruiting 4,000 infants who join Baby Navigator by 9 months of age. All families of children with a positive autism screen at each SoCo Checkup, and a comparison group with a negative screen, are invited to upload a video home observation that is coded using the Systematic Observation of Red Flags of ASD (SORF). The parent grant is addressing the following research aims: Aim 1. Study psychometric features of the SoCo Checkup cut-off and composite to diagnostic outcome; Aim 2. Study the trajectories of the SoCo surveillance and screening to predict severity of autism diagnostic features; and Aim 3. Construct a risk algorithm based on multiple parameters to develop an efficient, cost-effective mobile screening application for use in infants that is readily deployable in the general population. The expected outcomes of this validation study will demonstrate the effectiveness of an online surveillance and screening system beginning in the first year of life that will be ready for immediate, rapid, scalable, and sustainable deployment across the US. In response to NOT-DC-23-005, this administrative supplement will build upon our previous research on late talkers and capitalize on the evaluation of children recruited for the parent grant to contribute to elucidation of early social communication trajectories and unique language outcomes of late talking children in this sample. Of the children recruited and screened in the parent grant, 1,768 will be 2-4 years of age during the supplement project period. We will invite 300 children to participate in the supplement follow-up evaluations at 2-4 years of age. The evaluations in the parent grant will be enhanced by coding new early measures based on observation of social communication and language (OSCL) and observation of responsive parenting strategies (ORPS) as part of the supplement using the collected home observations from the parent grant. This supplement will address the following research aims: Aim 1. To study associations among new measures coding the OSCL and ORPS from the home observations and the collected measures in the parent grant—the SoCo CheckUp and SORF from 9-24 months; Aim 2. To study trajectories of the SoCo CheckUp, SORF, OSCL, and ORPS from 9- 24 months in predicting new measures of language outcomes at 2-4 years of age; and Aim 3. To examine sociocultural demographic indicators as predictors of social communication trajectories and language outcomes of late talkers. The early social communication measures and sociocultural indicators together with these new measures of language at 2-4 years will enhance data available to characterize differential trajectories to predict language outcomes and improve our understanding of the developmental sequalae for late talking children. Page 1 of 1

摘要 父R 01 MH 121364调查的目标是验证新的自动化 基于家长报告的在线筛选工具-社会沟通（SoCo）检查， 结合了沟通延迟和自闭症谱系障碍（ASD）的临床测试筛选项目。 这项家长调查招募了4,000名9个月大的婴儿加入婴儿导航员。的万族 在每次SoCo检查中具有阳性自闭症筛查的儿童，以及具有阴性筛查的对照组， 请上传一个视频家庭观察，使用红旗系统观察编码， ASD（SORF）。家长补助金旨在实现以下研究目标：目标1。研究心理测量 SoCo Checkup截止值和诊断结果的复合特征;目的2。研究了 SoCo监测和筛查，以预测自闭症诊断特征的严重程度;以及目标3。构建风险 算法的基础上，多个参数，以开发一个有效的，具有成本效益的移动的筛选应用程序， 在婴儿中使用，易于在一般人群中使用。本验证研究的预期结果 将在2010年的第一年开始展示在线监督和筛查系统的有效性。 生命，将准备立即，快速，可扩展和可持续的部署在美国各地。 作为对NOT-DC-23-005的回应，本行政补充文件将建立在我们之前对后期 谈话者，并利用对父母补助金招募的儿童的评价，以帮助阐明 早期的社会交往轨迹和独特的语言结果晚说话的孩子在这个样本中。的 在父母补助金中招募和筛选的儿童中，1 768人在补助金期间将为2-4岁 项目期间。我们将邀请300名儿童在2-4岁时参加补充剂的随访评估。 年龄通过对基于观察的新的早期措施进行编码， 社会沟通和语言（OSCL）和观察反应性父母策略（ORPS）， 使用从父母补助金中收集的家庭观察结果的补充部分。该补充将 研究目的：目的1。研究OSCL编码的新措施之间的关联， 从家庭观察和父母补助金中收集的措施-SoCo CheckUp和 9-24个月的SORF;目标2。为了研究9- 10岁儿童的SoCo CheckUp、SORF、OSCL和ORPS的轨迹， 2- 4个月预测2-4岁语言结果的新措施;目标3。审查 社会文化人口指标作为社会交往轨迹和语言成果的预测指标 迟到的谈话者早期的社会交流措施和社会文化指标，以及这些新的 2-4岁时的语言测量将增强可用于描述差异轨迹的数据，以预测 语言成果，并提高我们对晚说话儿童发展后遗症的理解。 页1的1