Investigating Early Social Communication Trajectories of Late Talking Toddlers to Best Predict Language Outcomes for the NIH TALK Initiative

调查晚说话幼儿的早期社交沟通轨迹，以最好地预测 NIH TALK 计划的语言结果

• 批准号: 10842062
• 负责人: AMY M WETHERBY
• 金额: $ 57.21万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-18 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10842062
• 关键词: 4 year old; Address; Administrative Supplement; Age Months; Algorithms; Autism diagnostic; Child; Child Rearing; Code; Communication; Data; Development; Developmental Delay Disorders; Diagnostic; Early Diagnosis; Education; Effectiveness; Evaluation; Family; General Population; Goals; Home; Infant; Investigation; Language; Language Delays; Life; Measures; Outcome; Parents; Psychometrics; Reporting; Research; Risk; Sampling; Screening procedure; Severities; System; Testing; Toddler; United States National Institutes of Health; autism spectrum disorder; checkup examination; comparison group; cost effective; effectiveness validation; follow-up; improved; language outcome; parent grant; recruit; response; screening; skills; social communication; social culture; social observations; validation studies

ABSTRACT The goal of the parent R01 MH121364 investigation is to validate the effectiveness of a new automated online screening tool based on parent report—the Social Communication (SoCo) CheckUp—which incorporates empirically-tested screening items for communication delay and autism spectrum disorder (ASD). The parent investigation is recruiting 4,000 infants who join Baby Navigator by 9 months of age. All families of children with a positive autism screen at each SoCo Checkup, and a comparison group with a negative screen, are invited to upload a video home observation that is coded using the Systematic Observation of Red Flags of ASD (SORF). The parent grant is addressing the following research aims: Aim 1. Study psychometric features of the SoCo Checkup cut-off and composite to diagnostic outcome; Aim 2. Study the trajectories of the SoCo surveillance and screening to predict severity of autism diagnostic features; and Aim 3. Construct a risk algorithm based on multiple parameters to develop an efficient, cost-effective mobile screening application for use in infants that is readily deployable in the general population. The expected outcomes of this validation study will demonstrate the effectiveness of an online surveillance and screening system beginning in the first year of life that will be ready for immediate, rapid, scalable, and sustainable deployment across the US. In response to NOT-DC-23-005, this administrative supplement will build upon our previous research on late talkers and capitalize on the evaluation of children recruited for the parent grant to contribute to elucidation of early social communication trajectories and unique language outcomes of late talking children in this sample. Of the children recruited and screened in the parent grant, 1,768 will be 2-4 years of age during the supplement project period. We will invite 300 children to participate in the supplement follow-up evaluations at 2-4 years of age. The evaluations in the parent grant will be enhanced by coding new early measures based on observation of social communication and language (OSCL) and observation of responsive parenting strategies (ORPS) as part of the supplement using the collected home observations from the parent grant. This supplement will address the following research aims: Aim 1. To study associations among new measures coding the OSCL and ORPS from the home observations and the collected measures in the parent grant—the SoCo CheckUp and SORF from 9-24 months; Aim 2. To study trajectories of the SoCo CheckUp, SORF, OSCL, and ORPS from 9- 24 months in predicting new measures of language outcomes at 2-4 years of age; and Aim 3. To examine sociocultural demographic indicators as predictors of social communication trajectories and language outcomes of late talkers. The early social communication measures and sociocultural indicators together with these new measures of language at 2-4 years will enhance data available to characterize differential trajectories to predict language outcomes and improve our understanding of the developmental sequalae for late talking children. Page 1 of 1

抽象的 母 R01 MH121364 调查的目标是验证新的自动化系统的有效性 基于家长报告的在线筛查工具——社交沟通 (SoCo) CheckUp—— 包含针对沟通延迟和自闭症谱系障碍 (ASD) 进行经验测试的筛查项目。 家长调查正在招募 4,000 名 9 个月大时加入 Baby Navigator 的婴儿。所有家庭 每次 SoCo 检查时自闭症筛查呈阳性的儿童，以及筛查呈阴性的对照组， 受邀上传使用“红旗系统观察”编码的家庭观察视频 ASD（SORF）。家长资助旨在实现以下研究目标： 目标 1. 研究心理测量学 SoC 检查截止点和综合诊断结果的特征；目标 2. 研究物体的轨迹 SoCo 监测和筛查以预测自闭症诊断特征的严重程度；目标 3. 构建风险 基于多个参数的算法，开发高效、经济高效的移动筛查应用程序 婴儿中的使用很容易在一般人群中使用。本验证研究的预期结果 将从第一年开始展示在线监测和筛查系统的有效性 的生活将准备好立即、快速、可扩展且可持续地在美国各地部署。 为了回应 NOT-DC-23-005，本行政补充文件将建立在我们之前对最新研究的基础上 谈话者并利用对父母补助金招募的儿童的评估来帮助阐明 该样本中说话晚的儿童的早期社会沟通轨迹和独特的语言结果。的 在家长补助金中招募和筛选的儿童中，有 1,768 名儿童在补贴期间年龄为 2-4 岁 项目期。我们将邀请300名孩子参加2-4岁的补充跟踪评估 年龄。通过基于观察编写新的早期措施，将增强父补助金中的评估 社会沟通和语言（OSCL）以及响应性养育策略（ORPS）的观察 补充部分使用从家长补助金中收集的家庭观察结果。本补充将 解决以下研究目标： 目标 1. 研究编码 OSCL 和 来自家庭观察和家长补助金中收集的措施的 ORPS - SoCo CheckUp 和 SORF 9-24 个月；目标 2. 研究 9-9 年间 SoC CheckUp、SORF、OSCL 和 ORPS 的轨迹 24 个月预测 2-4 岁语言结果的新指标；目标 3. 检查 社会文化人口指标作为社会沟通轨迹和语言结果的预测指标 迟到的谈话者。早期的社会沟通措施和社会文化指标以及这些新的 2-4岁时的语言测量将增强可用于表征差异轨迹的数据以进行预测 语言结果并提高我们对说话晚儿童的发展后遗症的理解。 第 1 页，共 1 页