Investigating Early Social Communication Trajectories of Late Talking Toddlers to Best Predict Language Outcomes for the NIH TALK Initiative

调查晚说话幼儿的早期社交沟通轨迹，以最好地预测 NIH TALK 计划的语言结果

• 批准号: 10842062
• 负责人: AMY M WETHERBY
• 金额: $ 57.21万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-18 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10842062
• 关键词: 4 year old; Address; Administrative Supplement; Age Months; Algorithms; Autism diagnostic; Child; Child Rearing; Code; Communication; Data; Development; Developmental Delay Disorders; Diagnostic; Early Diagnosis; Education; Effectiveness; Evaluation; Family; General Population; Goals; Home; Infant; Investigation; Language; Language Delays; Life; Measures; Outcome; Parents; Psychometrics; Reporting; Research; Risk; Sampling; Screening procedure; Severities; System; Testing; Toddler; United States National Institutes of Health; autism spectrum disorder; checkup examination; comparison group; cost effective; effectiveness validation; follow-up; improved; language outcome; parent grant; recruit; response; screening; skills; social communication; social culture; social observations; validation studies

ABSTRACT The goal of the parent R01 MH121364 investigation is to validate the effectiveness of a new automated online screening tool based on parent report—the Social Communication (SoCo) CheckUp—which incorporates empirically-tested screening items for communication delay and autism spectrum disorder (ASD). The parent investigation is recruiting 4,000 infants who join Baby Navigator by 9 months of age. All families of children with a positive autism screen at each SoCo Checkup, and a comparison group with a negative screen, are invited to upload a video home observation that is coded using the Systematic Observation of Red Flags of ASD (SORF). The parent grant is addressing the following research aims: Aim 1. Study psychometric features of the SoCo Checkup cut-off and composite to diagnostic outcome; Aim 2. Study the trajectories of the SoCo surveillance and screening to predict severity of autism diagnostic features; and Aim 3. Construct a risk algorithm based on multiple parameters to develop an efficient, cost-effective mobile screening application for use in infants that is readily deployable in the general population. The expected outcomes of this validation study will demonstrate the effectiveness of an online surveillance and screening system beginning in the first year of life that will be ready for immediate, rapid, scalable, and sustainable deployment across the US. In response to NOT-DC-23-005, this administrative supplement will build upon our previous research on late talkers and capitalize on the evaluation of children recruited for the parent grant to contribute to elucidation of early social communication trajectories and unique language outcomes of late talking children in this sample. Of the children recruited and screened in the parent grant, 1,768 will be 2-4 years of age during the supplement project period. We will invite 300 children to participate in the supplement follow-up evaluations at 2-4 years of age. The evaluations in the parent grant will be enhanced by coding new early measures based on observation of social communication and language (OSCL) and observation of responsive parenting strategies (ORPS) as part of the supplement using the collected home observations from the parent grant. This supplement will address the following research aims: Aim 1. To study associations among new measures coding the OSCL and ORPS from the home observations and the collected measures in the parent grant—the SoCo CheckUp and SORF from 9-24 months; Aim 2. To study trajectories of the SoCo CheckUp, SORF, OSCL, and ORPS from 9- 24 months in predicting new measures of language outcomes at 2-4 years of age; and Aim 3. To examine sociocultural demographic indicators as predictors of social communication trajectories and language outcomes of late talkers. The early social communication measures and sociocultural indicators together with these new measures of language at 2-4 years will enhance data available to characterize differential trajectories to predict language outcomes and improve our understanding of the developmental sequalae for late talking children. Page 1 of 1

抽象的 父级R01 MH121364调查的目标是验证新自动化的有效性 基于父母报告的在线筛查工具 - 社交沟通（SOCO）检查 - 结合经过经验测试的筛查项目，以进行沟通延迟和自闭症谱系障碍（ASD）。 父母投资正在招募4,000名婴儿在9个月大之前加入婴儿航海家的婴儿。所有的家庭 每个SOCO检查的儿童有积极的自闭症屏幕，以及一个具有负面屏幕的比较组， 邀请使用对危险信号的系统观察进行编码的视频家庭观察 ASD（SORF）。父母赠款正在解决以下研究目的：目标1。学习心理测量学 SOCO检查临界值的特征和诊断结果的复合材料；目标2。研究 SOCO监视和筛查以预测自闭症诊断特征的严重程度；和目标3。建立风险 基于多个参数的算法，以开发有效的，具有成本效益的移动筛选应用程序 在一般人群中很容易部署的婴儿中使用。这项验证研究的预期结果 将展示从第一年开始的在线监视和筛选系统的有效性 将准备在整个美国进行即时，快速，可扩展和可持续部署的生活。 为了响应非DC-23-005，这种行政补充将基于我们先前关于迟到的研究 谈话者并利用对父母赠款招募的儿童的评估，以促进 早期的社交沟通轨迹和该样本中的较晚儿童的独特语言结果。的 在父母赠款中招募和筛选的孩子，在补充期间，有1,768岁的孩子将为2-4岁 项目期。我们将邀请300名儿童参加2 - 4年的补充后续评估 年龄。父母赠款中的评估将通过根据观察来编码新的早期措施来增强 社会交流和语言（OSCL）以及对响应式育儿策略（ORP）的观察 使用父母赠款收集的房屋观察的一部分补充剂。这种补充会 解决以下研究目的：目的1。研究编码OSCL和OSCL的新措施之间的关联 来自家庭观察的ORP和父母赠款中的收集措施 - SOCO检查和 9-24个月的SORF；目的2。研究9-的SOCO检查，SORF，OSCL和ORP的轨迹 24个月预测2-4岁时语言结果的新措施；目标3。考试 社会文化人口统计指标是社会交流轨迹和语言成果的预测指标 已故的谈话者。早期的社会交流措施和社会文化指标以及这些新的 2 - 4年时的语言度量将增强可用的数据以表征差异轨迹以预测 语言结果并提高了我们对已故儿童的发育序列的理解。 第1页，共1页