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Metabolic and Energetic Consequences of Fatherhood

父亲身份对新陈代谢和精力的影响

基本信息

批准号：
8686914
负责人：
Mark A Chappell
金额：
$ 18.47万
依托单位：
UNIVERSITY OF CALIFORNIA RIVERSIDE
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-01 至 2016-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8686914
关键词：
Acute Address Adverse effects Affect Age Androgens Animals Behavior Biological Biological Markers Biological Models Biology Blood Blood Glucose Body Composition Body fat California Caring Child Cholesterol Chronic Chronic stress Corticosterone Cross-Sectional Studies Data Development Diet Eating Endocrine Energy Metabolism Exposure to Fasting Fathers Fatty acid glycerol esters Feeding behaviors Female Foundations Future Glucocorticoids Glucose Health Homeostasis Hormonal Hormones Housing Human Laboratories Lead Leptin Link Longevity Longitudinal Studies Mammals Measures Mediating Mental Health Metabolic Metabolism Morbidity - disease rate Mus Noise Organ Outcome Pair Bond Parents Partner in relationship Paternal Age Peromyscus Physiological Plasma Postpartum Period Process Prolactin Psychosocial Stress Regulation Research Rest Rodent Solutions Stress Sucrose Testing Testosterone Thyroid Hormones Thyroxine Time Triglycerides Triiodothyronine Woman adiponectin disorder risk experience fatherhood improved insight longitudinal design male male health men mortality motherhood offspring parity physical conditioning preference protective effect public health relevance pup reproductive research study stressor

项目摘要

DESCRIPTION (provided by applicant): Fatherhood can influence health and longevity in men. The mechanisms underlying these effects are unknown; however, as human and other mammalian fathers undergo predictable changes in several metabolically important hormones, one possibility is that these endocrine profiles influence energy homeostasis, metabolism, and body composition, which in turn can affect health and longevity. The proposed studies will characterize the effects of fatherhood in the California mouse (Peromyscus californicus), a monogamous rodent in which fathers invest extensively in their offspring and undergo systematic changes in hormone levels and body mass. Specifically, this research will test the hypotheses that fatherhood alters: plasma levels of metabolically important hormones (Aim 1); energy homeostasis, metabolism, body mass, and body fat (Aim 2); behaviors that may contribute to these energetic and metabolic effects (Aim 3); and that these consequences of fatherhood are modulated by paternal parity/age, offspring age, and stress. Experiment 1 will use a longitudinal design to characterize the effects of fatherhood on physical (body mass, body composition), energetic (resting and maximal metabolic rates, daily energy expenditure), hormonal (corticosterone, testosterone), and behavioral (ingestive behavior, activity levels) measures. Data will be collected at five time points, spanning approximately a 9-month period, from fathers (housed with a mate and pups) and nonbreeding males (housed with an ovariectomized female). Half of the mice in each group will be exposed to a chronic, intermittent noise stressor, and the other half will be maintained under standard laboratory conditions. Experiment 2 will use a cross-sectional approach to further characterize possible hormonal, metabolic, and behavioral mechanisms underlying the anticipated effects of fatherhood on body mass, body composition, and energetics. Specifically, it will characterize 1) circulating levels of the metabolic hormones leptin, adiponectin, triiodothyronine, and thyroxine; 2) blood triglyceride, cholesterol, and glucose levels; 3) the propensity to ingest high-fat and high-sucrose substances; and 4) organ masses and distribution of fat stores, in nonbreeding males, new fathers, and experienced fathers. Depending on the results of Experiment 1, half of the mice in each group may again be exposed to a chronic, intermittent noise stressor. These studies are expected to demonstrate that fatherhood in P. californicus alters metabolic hormone levels, energy homeostasis, metabolism, body composition, and behavior. They will also clarify how these effects are modulated by paternal age/parity, offspring age, and chronic stress. The results will provide unique insights into the biology of mammalian fatherhood and may eventually lead to an improved understanding of the effects of fatherhood on health and longevity in men, as well as health outcomes in their offspring.

描述（由申请人提供）：父亲身份可以影响男性的健康和寿命。这些影响的机制尚不清楚；然而，由于人类和其他哺乳动物的父亲在几种代谢重要激素方面经历了可预测的变化，一种可能性是这些内分泌特征会影响能量稳态、新陈代谢和身体成分，进而影响健康和寿命。拟议的研究将描述加州小鼠（Peromyscus californicus）中父亲身份的影响，加州小鼠是一种一夫一妻制的啮齿动物，父亲对后代进行了大量投资，并在激素水平和体重方面经历系统性变化。具体来说，这项研究将测试父亲身份改变的假设：代谢重要激素的血浆水平（目标 1）；能量稳态、新陈代谢、体重和体脂（目标 2）；可能导致这些能量和代谢影响的行为（目标 3）；并且父亲身份的这些后果受到父权/年龄、后代年龄和压力的调节。实验1将使用纵向设计来描述父亲身份对身体（体重、身体成分）、精力（静息和最大代谢率、每日能量消耗）、激素（皮质酮、睾酮）和行为（摄入行为、活动水平）测量的影响。数据将在五个时间点收集，跨越大约 9 个月的时间，数据来自父亲（与配偶和幼崽一起饲养）和非繁殖雄性（与切除卵巢的雌性饲养）。每组中的一半小鼠将暴露于慢性、间歇性的噪音应激源，另一半将维持在标准实验室条件下。实验 2 将使用横断面方法来进一步表征父亲对体重、身体成分和能量的预期影响背后可能的激素、代谢和行为机制。具体来说，它将表征 1) 的循环水平代谢激素瘦素、脂联素、三碘甲状腺原氨酸和甲状腺素； 2）血甘油三酯，胆固醇和葡萄糖水平； 3）摄入高脂肪和高蔗糖物质的倾向； 4）非繁殖男性、新手父亲和经验丰富的父亲的器官质量和脂肪储存的分布。根据实验 1 的结果，每组中有一半的小鼠可能会再次暴露于慢性、间歇性的噪音应激源。这些研究预计将证明加利福尼亚拟南芥的父亲身份会改变代谢激素水平、能量稳态、新陈代谢、身体成分和行为。他们还将阐明这些影响如何受到父亲年龄/胎次、后代年龄和慢性压力的调节。这些结果将为哺乳动物父亲身份的生物学提供独特的见解，并最终可能导致更好地了解父亲身份对男性健康和寿命及其后代健康结果的影响。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Effects of a physical and energetic challenge on male California mice (Peromyscus californicus): modulation by reproductive condition.

体力和精力挑战对雄性加州小鼠（Peromyscus californicus）的影响：生殖条件的调节。

DOI：
10.1242/jeb.168559
发表时间：
2018
期刊：
The Journal of experimental biology
影响因子：
0
作者：
Zhao,Meng;GarlandJr,Theodore;Chappell,MarkA;Andrew,JacobR;Harris,BreannaN;Saltzman,Wendy
通讯作者：
Saltzman,Wendy

Effects of repeated pup exposure on behavioral, neural, and adrenocortical responses to pups in male California mice (Peromyscus californicus).