2015 Muscle: Excitation/Contraction Coupling Gordon Research Conference & Gordon Research Seminar

2015年肌肉：兴奋/收缩耦合戈登研究会议

• 批准号: 8825143
• 负责人: Robert T Dirksen
• 金额: $ 1.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-26 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8825143
• 关键词: Addendum; Aging; Area; Atrophic; Back; Basic Science; Calcium Signaling; Clinical; Clinical Research; Communication; Communities; Coupling; Defect; Development; Discipline; Disease; Elements; Environment; Functional disorder; Gender; Geographic Locations; Goals; Government; Growth; Health; Human; Individual; Inherited; International; Knowledge; Lead; Leadership; Maintenance; Metabolic Diseases; Metabolism; Modification; Molecular; Muscle; Muscle Fatigue; Mutation; Myocardium; Myopathy; Neuromuscular Diseases; Outcome; Oxidation-Reduction; Participant; Patients; Performance; Postdoctoral Fellow; Process; Proteins; Quality of life; Race; Regulation; Research; Research Personnel; Resolution; Resort; Rivers; Roentgen Rays; Ryanodine Receptor Calcium Release Channel; Scientist; Site; Skeletal Muscle; Staging; Structure; Students; Switzerland; Time; Translational Research; Triad Acrylic Resin; Universities; University Hospitals; Work; base; career; combat; effective therapy; experience; graduate student; improved; innovation; insight; meetings; muscle metabolism; new therapeutic target; news; novel; novel strategies; posters; programs; public health relevance; sarcopenia; symposium

 DESCRIPTION (provided by applicant): This is a proposal for partial support of the only major national or international meeting dedicated to excitation/contraction coupling and how defects in this critical process underlie muscle disease. The Muscle: Excitation/Contraction Coupling (ECC) Gordon Research Conference (GRC) will meet from May 30 - June 5, 2015 at the new Sunday River Resort GRC site in Newry, ME. The GRC program was developed by an Executive Organizing Committee consisting of leaders in ECC research including Drs. Robert T. Dirksen (University of Rochester), Susan Treves (Basel University Hospital), and Isaac N. Pessah (UC Davis). The two overarching objectives of the 2015 Muscle: Excitation/Contraction Coupling GRC are: Objective 1: To discuss and critically evaluate new breakthroughs regarding the molecular mechanisms that control ECC and how this process is altered in muscle fatigue, atrophy, sarcopenia, metabolic disease, and genetically-inherited forms of skeletal and cardiac muscle disease. Objective 2: To promote visibility and leadership of junior investigators in the field by providing a platform for students, postdoctoral fellows, and new independent investigators to present their work, as well as to interact and network with established senior investigators. The 2015 GRC conference will consist of 35 speakers, 18 Discussion Leaders, and 16 poster presentations. Scientific sessions will focus on structural studies of the ECC apparatus, new insights into the molecular mechanisms and regulation of ECC, identification of new therapeutic targets, and the development of innovative treatments for muscle fatigue, sarcopenia, and skeletal and cardiac muscle disorders that adversely impact millions of individuals in the US. For the first time for this GRC, the meeting will be preceded by a two-day Gordon Research Seminar (GRS) for graduate students and postdoctoral fellows. In addition, a different young investigator will be paired with a senior investigator to serve as Co-Discussion Leaders for sessions during the GRC. Innovative "Rapid Poster Preview" and "This Just In" speaker slots will be used to highlight late-breaking news. These innovative program elements will also maximize poster session visibility, as well as to enhance the integration and exposure of promising young investigators in the field during the GRC. We expect that this conference will attract 150-200 basic and clinical scientists across all career stages, genders, races, heritages, research disciplines, professional affiliations (academic, industrial, government), and geographical locations. Our overall aim is to promote: 1) open dialogue and communication, 2) exposure and career advancement of promising young investigators in the field, 3) fundamental understanding in the mechanisms of ECC and how defects in this process lead to compromised muscle performance, and 4) the development of novel and effective therapies to combat skeletal and cardiac muscle disorders.

 描述（由申请人提供）：这是一项提案，旨在部分支持唯一一次主要的国家或国际会议，专门讨论兴奋/收缩耦合以及这一关键过程中的缺陷如何导致肌肉疾病。肌肉：激励/收缩耦合（ECC）戈登研究会议（GRC）将于2015年5月30日至6月5日在新的星期日河度假村GRC网站纽里，ME。GRC计划是由一个执行组织委员会，包括博士ECC研究的领导人，包括罗伯特T。Dirksen（罗切斯特大学），Susan Treves（巴塞尔大学医院）和Isaac N. Pessah（UC Davis）. 2015年肌肉：兴奋/收缩耦合GRC的两个首要目标是：目标1：讨论和批判性评估有关控制ECC的分子机制的新突破，以及这一过程如何在肌肉疲劳，萎缩，肌肉减少症，代谢疾病和遗传形式的骨骼肌和心肌疾病中改变。目标二：通过为学生，博士后研究员和新的独立研究人员提供一个平台来展示他们的工作，以及与现有的高级研究人员进行互动和建立网络，以提高初级研究人员在该领域的知名度和领导力。 2015年GRC会议将由35位演讲者，18位讨论领导者和16位海报展示组成。科学会议将侧重于ECC装置的结构研究，对ECC分子机制和调控的新见解，新的治疗靶点的识别，以及对肌肉疲劳，肌肉减少症，骨骼肌和心肌疾病的创新治疗方法的开发，这些疾病对美国数百万人产生了不利影响。对于这个GRC的第一次，会议将由为期两天的研究生和博士后研究员戈登研究研讨会（GRS）之前。此外，另一名年轻研究员将与一名高级研究员配对，担任GRC会议期间的共同讨论领导人。创新的“快速海报预览”和“这只是在”扬声器插槽将被用来突出最新的新闻。这些创新的计划元素还将最大限度地提高海报会议的知名度，并在GRC期间加强有前途的年轻研究人员在该领域的整合和曝光。 我们预计本次会议将吸引150-200名基础和临床科学家，他们来自各个职业阶段、性别、种族、遗产、研究学科、专业背景（学术、工业、政府）和地理位置。我们的总体目标是促进：1）公开对话和交流，2）在该领域有前途的年轻研究人员的曝光和职业发展，3）对ECC机制的基本理解以及该过程中的缺陷如何导致肌肉性能受损，以及4）开发新颖有效的治疗方法来对抗骨骼和心肌疾病。